Abstract: Disclosed are various synthetic methods to prepare structural analogs of largazole and derivatives thereof. One structural analog is an amide isostere of largazole. Another structural analog replaces the thiazole ring of largazole with a pyridine moiety or an oxazole moiety.
Type:
Application
Filed:
December 16, 2021
Publication date:
February 22, 2024
Applicants:
COLORADO STATE UNIVERSITY RESEARCH FOUNDATION, CETYA THERAPEUTICS, INC.
Inventors:
Robert M. WILLIAMS, Sivanagireddy KOTI, Subhadip DE, Anil M. SHELKE, Ryan E. CERBONE, Nobuyoshi YASUDA