Abstract: Disclosed by the present application is a crystalline form of a capsid protein assembly inhibitor containing an N hetero five-membered ring; specifically disclosed is the crystalline form of the compound of formula I; also comprised is an the application of said crystalline form in the preparation of a drug for preventing or treating diseases benefiting from the inhibition of capsid protein assembly.
Type:
Application
Filed:
September 28, 2020
Publication date:
November 17, 2022
Applicant:
CHAI, TAI TIANQING PHARMACEUTICAL GROUP CO.,LTD.
Abstract: Provided are a sultam compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity as represented by formula I or pharmaceutically-acceptable salts, solvates or hydrates thereof, a preparation method thereof, and a pharmaceutical composition containing the compound. The compound or the pharmaceutically-acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition containing the compound can be used to treat IDH1 mutation-induced cancers.
Type:
Grant
Filed:
March 22, 2017
Date of Patent:
September 7, 2021
Assignees:
Chai Tai Tianqing Pharmaceutical Group Co., Ltd., Lianyungang Runzhong Pharmaceutical Co., Ltd., Centaurus Biopharma Co., Ltd.
Abstract: The present application relates to maleates of a compound of Formula I, methods for preparing the same, pharmaceutical compositions thereof and uses thereof in the treatment of tumors, such as non-small cell lung cancer, breast cancer, and other malignant tumors.
Type:
Grant
Filed:
March 18, 2016
Date of Patent:
March 19, 2019
Assignees:
Chai Tai Tianqing Pharmaceutical Group Co., Ltd., CENTAURUS BIOPHARMA CO., LTD., LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
Inventors:
Xiquan Zhang, Song Tang, Weiwei Feng, Xin Tian, Zhilin Chen, Hongmei Gu, Hongjiang Xu, Fei Liu