Abstract: A transmission platform can modify transmissions of outputs based on the impact of the outputs on various segments of users. The transmission platform can initiate a transmission of outputs to a non-control group of users and receive results generated by both the non-control group of users and a control group of users who did not receive the output. The transmission platform can determine segments of users based on certain characteristics and can compare the results, within each segment, from the control and non-control groups. The transmission platform can identify certain segments for which the difference in results is statistically significant, indicating that the output caused a positive impact for those segments. The transmission platform can modify the transmission to target these segments with future outputs and can prioritize those segments demonstrating the greatest impact (e.g., the greatest difference between the control and non-control groups).