Patents Assigned to Chang Gung University
  • Publication number: 20230364011
    Abstract: Disclosed herein is a method for alleviating dry eye syndrome using a composition containing a polylysine nanoparticle. The polylysine nanoparticle is produced by subjecting lysine hydrochloride to a pyrolysis treatment at a temperature ranging from 240° C. to 280° C.
    Type: Application
    Filed: September 19, 2022
    Publication date: November 16, 2023
    Applicant: Chang Gung University
    Inventors: Jui-Yang Lai, Chih-Ching Huang, Han-Jia Lin, Hong-Jyuan Jian
  • Patent number: 11806088
    Abstract: A method includes providing medical images of a subject for selecting a target image from thereamong, building a 3D image model based on the medical images and the target image with a surgical target site assigned, performing image registration to superimpose the 3D image model on a real-time image of the subject so as to result in a combined image, determining a virtual entry site located on the combined image, connecting the surgical target site and the virtual entry site with a straight line, generating a guiding path extending from the virtual entry site, in a direction away from the surgical target site and along the straight line, and displaying the guiding path for guiding a surgical instrument.
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: November 7, 2023
    Inventors: Shin-Yan Chiou, Pin-Yuan Chen, Hao-Li Liu, Kuo-Chen Wei
  • Publication number: 20230321078
    Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, comprising administering an effective amount of plant extract, wherein the plant extract comprises an alcohol extract of the herbal of Menispermaceae, wherein the herbal of Menispermaceae is Stephania cepharantha or Stephania tetrandra.
    Type: Application
    Filed: June 10, 2022
    Publication date: October 12, 2023
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long Hwang, Yu-Li Chen, Yu-Chia Chang
  • Patent number: 11744765
    Abstract: A standing training mobile device for carrying a patient to perform active-assisted upright locomotion is provided. The standing training mobile device includes a base, a mobile module, a lifting module, a control module, and a support module. The mobile module and the lifting module are disposed on the base. The control module is disposed on the lifting module and is coupled to the mobile module. The control module includes a manipulation platform and two control assemblies disposed on the manipulation platform for use of the patient. The support module includes a support frame, a first support assembly, a second support assembly, and a third support assembly. The first support assembly, the second support assembly, and the third support assembly are slidably disposed on the support frame respectively. The second support assembly is disposed between the first support assembly and the third support assembly.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: September 5, 2023
    Inventors: Wen-Yu Liu, Hen-Yu Lien, Chung-Hsien Kuo, Yang-Hua Lin
  • Patent number: 11712178
    Abstract: A plantar pressure sensing system is located at a sole of shoe. The plantar pressure sensing system includes a first layer, a second layer a plurality of sensor, a plurality of convex portions, a plurality of connection portions, a processor and a storage. The processor is coupled with the storage and configured to be connected with the plurality of sensors. The plurality of sensors are configured to form the first layer. The plurality of convex portions and the plurality of connection portions are configured to form the second layer. Overall, the plantar pressure sensing system is able to detect pressure with the sensors by setting the alignment of the convex portions, thereby obtaining a more accurate pressure(s) reading from the sole of shoe. The data validity of the plantar pressure sensing system is improved.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: August 1, 2023
    Inventors: Hsiao-Lung Chan, Jiunn-Woei Liaw, Ya-Ju Chang, Cheng-Chung Kuo
  • Patent number: 11698357
    Abstract: The present disclosure provides a method for screening, isolating and purifying analytes.
    Type: Grant
    Filed: July 5, 2019
    Date of Patent: July 11, 2023
    Inventors: Min-Hsien Wu, Po-Yu Chu, Wen-Pin Chou, Chia-Jung Liao
  • Patent number: 11679102
    Abstract: Disclosed herein is a method for inhibiting virus infection, including administering to a subject in need thereof an effective amount of a ferroptosis inhibitor or a pharmaceutically acceptable salt thereof. Also disclosed is a method for inhibiting viral replication, including contacting a virus with a ferroptosis inhibitor or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: June 20, 2023
    Assignee: Chang Gung University
    Inventors: Shin-Ru Shih, Yu-An Kung, Huan-Jung Chiang, Chuan-Tien Hung, Yu-Nong Gong, Hsin-Ping Chiu, Chiung-Guei Huang, Peng-Nien Huang, Sheng-Yu Huang
  • Patent number: 11653903
    Abstract: The invention relates to an automatic reflection hammer system, which comprises the following components: a reflective hammer chassis, an outer side having a detachable reflection hammer head, and a pulley, a universal joint, a vertical height adjustment mechanism, and a fixing bracket. Wherein, the reflection hammer chassis links with the universal joint, the universal joint links to the vertical height adjustment mechanism, and the vertical height adjustment mechanism links with the fixing bracket.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: May 23, 2023
    Inventors: Jer-Chyi Wang, Yi Fu, Kuo-Hsuan Chang
  • Patent number: 11634464
    Abstract: Disclosed herein are recombinant polypeptides derived from FBP1 and FBP2. Also disclosed herein are recombinant expression vectors and recombinant host cells for producing the aforesaid recombinant polypeptides. The recombinant polypeptides are proven to be useful and effective in producing a picornavirus with a type I internal ribosome entry site (IRES), so as to facilitate the preparation of a viral vaccine.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: April 25, 2023
    Inventors: Shin-Ru Shih, Yu-An Kung, Chuan-Tien Hung
  • Patent number: 11583848
    Abstract: The present invention discloses a nanoparticle control and detection system and operating method thereof. The present invention controls and detects the nanoparticles in the same device. The device comprises a first transparent electrode, a photoconductive layer, a spacer which is deposed on the edge of the photoconductive layer and a second transparent electrode. The aforementioned device controls and detects the nanoparticles by applying AC/DC bias and AC/DC light source to the transparent electrode.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: February 21, 2023
    Inventors: Chia-Ming Yang, Chao-Sung Lai, Yu-Ping Chen, Min-Hsien Wu
  • Publication number: 20230030454
    Abstract: Disclosed herein is a method for identifying and treating a Streptococcus pyogenes (group A Streptococcus, GAS) infection in a subject. The method mainly includes determining the presence of endopeptidase O (PepO) protein in the biological sample; and administering an effective amount of an anti-infective agent to the subject to ameliorate symptoms associated with the GAS infection if the PepO protein is present in the biological sample.
    Type: Application
    Filed: July 27, 2021
    Publication date: February 2, 2023
    Applicant: Chang Gung University
    Inventor: Chuan CHIANG-NI
  • Publication number: 20220339122
    Abstract: Disclosed herein is a method of treating diseases and/or disorders associated with the dysregulated activation and recruitment of neutrophils. The method includes administering to a subject in need thereof an effective amount of 3,3?-dihydroxy-2?,6?-bis(p-hydroxybenzyl)-5-methoxybibenzyl (or bletinib), a salt, a solvate or an ester thereof.
    Type: Application
    Filed: April 27, 2021
    Publication date: October 27, 2022
    Applicant: Chang Gung University
    Inventors: Tsong-Long HWANG, Ting-I KAO, Tian-Shung WU
  • Patent number: 11452754
    Abstract: Pharmaceutical compositions containing a combination of rhizoma coptidis and a herbal composition comprises at least one herb selected from the group consisting of Radix Ginseng, Poria, Rhizoma Atractylodis macrocephalae, Semen Lablab album, Rhizoma Dioscoreae, Embryo Nelumbinis, Radix Platycodonis, Semen Coicis, Fructus Amomi, Fructus Jujubae and Radix Glycyrrhizae are disclosed. Methods of treating diseases by administering an effective amount of the pharmaceutical composition are also provided.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: September 27, 2022
    Inventors: Yi-Hong Wu, Yueh Hsiang Huang, Jong-Hwei Su Pang
  • Patent number: 11452709
    Abstract: The invention provides novel compositions and methods for the treatment of Radiation-Induced Bystander Effects (RIBE), resulting from radiation exposure. In one preferred embodiment the inventions includes novel therapeutic agents, including but not limited to quercetin and quercetin analogs, as well as E64, CA074, CA074Me, that interfere with the activity of Cathepsin B.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: September 27, 2022
    Inventors: Ding Xue, Yu Peng, Man Zhang, Lingjun Zheng, Qian Liang, Hanzeng Li, Jau-Song Yu, Jeng-Ting Chen
  • Patent number: 11421234
    Abstract: Provided herein is an aptamer specific to coagulation factor XIII (FXIII) and its uses thereof. Accordingly, the present aptamer is useful as a bio-tool to label thrombi, and/or as a targeting molecule to deliver drugs to thrombotic area. Therefore, the present disclosure also pertains to methods for treating diseases associated with FXIII, such as thrombosis.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: August 23, 2022
    Inventors: Yunn-Hwa Ma, Ching-Ping Tseng, Kai-Wen Cheng
  • Patent number: 11363968
    Abstract: A center of pressure (CoP) based control system includes a sensing device and an electronic device connected to the sensing device. The sensing device includes sensors each of which continuously measures force exerted thereon by a subject and generates a sense signal based on a result of the measurement. The electronic device is connected to the sensing device, and receives the sense signals from the respective sensors, generates CoP data associated with a CoP trajectory based on the sense signals, determines whether a turning point exists in the CoP trajectory, generates an indication signal based on a result of the determination, and generates a control signal based on a direction of one of displacements of the CoP.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: June 21, 2022
    Assignee: Chang Gung University
    Inventors: Ya-Ju Chang, Jiunn-Woei Liaw, Hung-Bin Chen
  • Patent number: 11351172
    Abstract: The invention provides a pharmaceutical composition for treating phosphodiesterase 4-mediated (PDE4-mediated) disease in a patient and inhibition of phosphodiesterase 4 (PDE4) activity. The pharmaceutical composition includes an effective amount of Ribociclib and a pharmaceutically acceptable carrier. The invention further provides a use of the pharmaceutical composition for treating PDE4-mediated disease in a patient. The application of the pharmaceutical composition of the present invention and use thereof are advantageous for inhibiting of PDE4 activity and thus treating a PDE4-mediated disease.
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: June 7, 2022
    Inventors: Tsong-Long Hwang, Po-Jen Chen
  • Patent number: 11344193
    Abstract: A method for performing an assessment of vision is provided, and comprises: determining a current difficulty level for the assessment; displaying a question of the assessment, the question including a visual element that has a movable pattern, the movable pattern having at least one variable attribute that is related to the current difficulty level; in response to receipt of an inputted answer, determining whether the inputted answer is correct; and determining whether the assessment is to be concluded, and in the affirmative, generating a result of the assessment based on the current difficulty level.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: May 31, 2022
    Inventors: Jyh-Da Wei, Jerry Chien-Chieh Huang, Shin-Yi Chen
  • Publication number: 20220146527
    Abstract: A method of creating characteristic profiles of mass spectra and identification model for analyzing and identifying microorganisms includes collecting m/z data of microorganisms having same features from MALDI-TOF MS; classifying the microorganisms; classifying the collected set of m/z data as a plurality of subsets; creating modified subsets by applying KDE to the subsets; creating first characteristic MS profiles based on the modified subsets; summarizing into a second characteristic MS profile; repeating above six steps to create second characteristic MS profiles; creating a training set comprising first matched vectors; training a machine learning system using the training set to establish a feature classification model; using MALDI-TOF MS to analyze microorganisms having unknown features; comparing m/z of MALDI-TOF MS spectrum of the microorganisms having unknown features with second characteristic MS profiles to obtain second matched vectors; using the feature classification model analyzing the second m
    Type: Application
    Filed: January 25, 2022
    Publication date: May 12, 2022
    Applicant: Chang Gung University
    Inventors: Jang-Jih Lu, Hsin-Yao Wang, Chia-Ru Chung, Jorng-Tzong Horng, Tzong-Yi Lee
  • Patent number: 11328791
    Abstract: A method for determining a human subject's risk of developing acute kidney injury (AKI) from acute myocardial infarction (AMI) includes: obtaining a blood sample; determining at least two miRNA expression levels therein, which are selected from miR-23a-3p, miR-24-3p, and miR-145-5p expression levels; calculating probability of developing AKI from AMI based on the at least two miRNA expression levels and a logistic regression model; comparing the probability with a predetermined standard; and determining that the human subject is at the risk of developing AKI when the probability is higher than the predetermined standard. A composition may be administered to the human subject for inhibiting development of AKI, if any.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: May 10, 2022
    Assignees: Chang Gung University, Chang Gung Memorial Hospital, Linkou
    Inventors: Pao-Hsien Chu, Yu-Sun Chang, Chia-Chun Chen, Pei-Chun Fan