Patents Assigned to Chang Gung University
  • Publication number: 20210217485
    Abstract: A method of establishing a coronary artery disease (CAD) prediction model for CAD screening includes establishing a data set in a computer equipment; entering the data set and corresponding future CAD condition of asymptomatic individuals into a machine learning component; selecting a plurality of robust variables from the clinical data and the cardiovascular markers of the cardiovascular markers panel by using feature selection methods; establishing the CAD prediction model by using machine learning methods; uploading new clinical data and new results of the cardiovascular markers to the cloud-based platform when any asymptomatic individuals undergo the health examination, and performing calculation and analysis by the CAD prediction model; and notifying the asymptomatic individuals of having a high risk of encountering a CAD event or not in a certain period of follow-up time.
    Type: Application
    Filed: April 1, 2021
    Publication date: July 15, 2021
    Applicants: CHANG GUNG MEMORIAL HOSPITAL, LINKOU, Chang Gung University, CATHAY GENERAL HOSPITAL
    Inventors: Jang-Jih Lu, Chun-Hsien Chen, Hsin-Yao Wang, Yi-Hsin Chan, Wei-Shang Shih
  • Publication number: 20210163945
    Abstract: Provided herein is an aptamer specific to coagulation factor XIII (FXIII) and its uses thereof. Accordingly, the present aptamer is useful as a bio-tool to label thrombi, and/or as a targeting molecule to deliver drugs to thrombotic area. Therefore, the present disclosure also pertains to methods for treating diseases associated with FXIII, such as thrombosis.
    Type: Application
    Filed: December 2, 2019
    Publication date: June 3, 2021
    Applicant: Chang Gung University
    Inventors: Yunn-Hwa MA, Ching-Ping TSENG, Kai-Wen CHENG
  • Patent number: 11013429
    Abstract: A method to identify feature points associated with the heart valve movement, heart contraction or cardiac hemodynamics is revealed. The mechanocardiography (MCG) is a technology that makes use of vibrational waveforms acquired using at least one gravity sensor attached on one of the four heart valve auscultation sites on the body surface. The data of the electrocardiography (ECG) is recorded simultaneously with the MCG The feature points are identified by comparing P, R and T points of synchronized ECG with the MCG spectrum. By the time sequences and amplitudes of the feature points, the method provides additional clinical information of cardiac cycle abnormalities for diagnosis.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: May 25, 2021
    Assignee: Chang Gung University
    Inventors: Wen-Yen Lin, Ming-Yih Lee, Po-Cheng Chang, Wen-Zheng Zhou
  • Patent number: 11011276
    Abstract: A method for establishing a computer-aided data interpretation model for immune diseases by immunomarkers and visualization is revealed. First combine a plurality of immunomarkers into an immunomarker panel. Then collect test data of a plurality of subjects measured by the immunomarker panel, and disease diagnosis information of the subjects for establishment of an immunomarker-panel testing database. Next new subjects are tested by the immunomarker panel. The data obtained and the corresponding information in the immunomarker-panel testing database are processed by unsupervised machine learning algorithm to get a computer-aided data interpretation model showing comparison of case distribution patterns. The method provides real-time analysis of multiple data to medical professionals for their reference. Thereby the correctness, the timeliness and the reproducibility of the interpretation result for the diagnosis and treatment of immune diseases are all improved.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: May 18, 2021
    Assignees: CHANG GUNG MEMORIAL HOSPITAL, LINKOU, CHANG GUNG UNIVERSITY
    Inventors: Chun-Hsien Chen, Yi-Ju Tseng, Hsin-Yao Wang, Wan-Ying Lin, Chih-Kuang Chen
  • Publication number: 20210128680
    Abstract: Provided herein are synthetic peptides and methods for treating cardiorespiratory diseases, particularly cardiopulmonary disorder (CPD) by use of the synthetic peptides. The present synthetic peptide has the amino acid sequence of X1EX2LRVANEVTLN (SEQ ID NO: 1), in which X1 is tyrosine (Y) or phenylalanine (F), and X2 is alanine (A) or cysteine (C). In preferred embodiments, an effective amount of the present synthetic peptide is administered to a subject suffering from CPD to ameliorate or alleviate symptoms associated therewith.
    Type: Application
    Filed: October 30, 2019
    Publication date: May 6, 2021
    Applicants: Chang Gung University, Chang Gung Memorial Hospital, Linkou
    Inventors: Ying-Ju LAI, Pao-Hsien CHU, Whei-Yang Winston KAO
  • Patent number: 10966955
    Abstract: Disclosed herein is an ocular drug delivery system, comprising a positively charged chitosan-modified hydrogel, a secretory phospholipase A2 (sPLA2) hydrolysable liposome encapsulating an anti-inflammatory drug and having a negative surface charge, a first thiolated hyaluronic acid (HA-SH) nanoparticle encapsulating a wound-healing drug and having a negative surface charge, and a second HA-SH nanoparticle encapsulating a transforming growth factor-? inhibitor and having a negative surface charge. The sPLA2 hydrolysable liposome and the first and second HA-SH nanoparticles are attached to the positively charged chitosan-modified hydrogel by electrostatic attraction. Uses of the system are also disclosed.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: April 6, 2021
    Assignee: Chang Gung University
    Inventors: Jui-Yang Lai, Li-Jyuan Luo, Chung-Cheng Lo, Duc Dung Nguyen
  • Publication number: 20210080384
    Abstract: A method of creating characteristic profiles of mass spectra and identification model for analyzing and identifying microorganisms includes obtaining data of MALDI-TOF MS of microorganisms having same features; using a kernel density estimation to generate characteristic profiles of an m/z of the data; creating a characteristic MS profile based on the m/z; repeating above three step until characteristic MS profiles of features of the microorganisms is obtained; comparing m/z of MALDITOF MS spectrum of known microorganisms with the characteristic profiles to obtain first matched vectors; using a machine learning method to establish a feature classification model; using MALDI-TOF MS to analyze microorganisms having unknown features; comparing the m/z of MALDI-TOF MS spectrum of the microorganisms having unknown features with the characteristic MS profiles to obtain second matched vectors; using the feature classification model to analyze the second matched vectors; and identifying the microorganisms having the
    Type: Application
    Filed: March 30, 2020
    Publication date: March 18, 2021
    Applicant: Chang Gung University
    Inventors: Jang-Jih Lu, Hsin-Yao Wang, Chia-Ru Chung, Jorng-Tzong Horng, Tzong-Yi Lee
  • Patent number: 10930371
    Abstract: A method of creating characteristic peak profiles of mass spectra and identification model for analyzing and identifying microorganisms are provided. MALDI-TOF MS data of microorganisms having the same feature are gathered. Discretization of the data is performed. Density-based clustering is used to find m/z values of spectral peaks with high probability of occurrence from the discretized data. A characteristic MS peak profile is created for every specific feature of microorganisms. Every such a characteristic profile forms a feature template. The mass spectrum of each known isolate is matched against all the feature templates and a number of matched vectors are obtained. The matched vectors are then concatenated into a single “integrated vector.” Then, a machine learning method and the integrated vectors generated from all known isolates are used to create a classification model for microorganism identification.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: February 23, 2021
    Assignees: CHANG GUNG MEMORIAL HOSPITAL, LINKOU, CHANG GUNG UNIVERSITY
    Inventors: Jang-Jih Lu, Chun-Hsien Chen, Hsin-Yao Wang, Tsui-Ping Liu
  • Publication number: 20210036511
    Abstract: An apparatus of preventing ESD and EMP coupled between a signal input and a signal output is provided with a first diode of forward bias including a positive terminal and a negative terminal connected to the signal input and ground respectively; and a first diode of reverse bias including a negative terminal and a positive terminal connected to the signal input and the ground respectively. The semiconductor is a diode including a p-type semiconductor region made of semiconductor material having a predetermined band gap and an n-type semiconductor region made of semiconductor material having a predetermined band gap. The predetermined band gap is greater than 3 eV. The diode operates in forward bias to discharge current generated by ESD and/or EMP. A method of preventing ESD and EMP is also provided.
    Type: Application
    Filed: July 17, 2020
    Publication date: February 4, 2021
    Applicant: Chang Gung University
    Inventor: Liann-Be Chang
  • Publication number: 20210002689
    Abstract: A method for detecting different properties in a microorganism population by ODEP force includes obtaining a microorganism sample solution having a plurality of microorganisms to be tested; pre-processing the microorganism sample solution to obtain a microorganism sample solution to be tested including the microorganisms having electrical properties differences; placing the microorganism sample solution to be tested in a channel of an ODEP device and activating an optical projection device to form at least one optical projection directed to the ODEP device; flowing the microorganism sample solution to be tested from one end of the channel to the other end thereof, and exerting an ODEP force on the optical projection device to generate a force having a direction different from a flowing direction of the microorganism sample solution to be tested; and detecting heterogeneity of the microorganisms based on strength differences of the ODEP force exerted on the respective microorganisms.
    Type: Application
    Filed: February 3, 2020
    Publication date: January 7, 2021
    Applicant: Chang Gung University
    Inventors: Jang-Jih Lu, Min-Hsien Wu, Chih-Yu Chen, Hsin-Yao Wang
  • Patent number: 10820945
    Abstract: A system includes an image capturing device, a subject reference marker disposed adjacent to a subject, a tool reference marker disposed on a treatment tool, a display device mounted on an operator, an operator reference marker disposed on the display device, and a processor. The image capturing device includes two image capturing modules that simultaneously and respectively capture two images of the operator, the subject, and the treatment tool. The processor receives the images, analyzes the images to obtain spatial locations of the reference markers, and transmits coordinate information and auxiliary information.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: November 3, 2020
    Assignees: CHANG GUNG UNIVERSITY
    Inventors: Hao-Li Liu, Shin-Yan Chiou, Chen-Yuan Liao, Wen-Yen Lin, Pin-Yuan Chen, Kuo-Chen Wei
  • Patent number: 10799151
    Abstract: A method to identify feature points associated with the heart valve movement, heart contraction or cardiac hemodynamics is revealed. The mechanocardiography (MCG) is a technology that makes use of vibrational waveforms acquired using at least one gravity sensor attached on one of the four heart valve auscultation sites on the body surface. The data of the electrocardiography (ECG) is recorded simultaneously with the MCG The feature points are identified by comparing P, R and T points of synchronized ECG with the MCG spectrum. By the time sequences and amplitudes of the feature points, the method provides additional clinical information of cardiac cycle abnormalities for diagnosis.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: October 13, 2020
    Assignee: Chang Gung University
    Inventors: Wen-Yen Lin, Ming-Yih Lee, Po-Cheng Chang, Wen-Zheng Zhou
  • Patent number: 10791996
    Abstract: An intraoperative nerve evaluation device includes a flexible substrate, and a plurality of detection units disposed on the substrate and spaced apart from one another. Each of the detection units includes an electrode and a conductive wire electrically connected to the electrode. When the electrodes are attached to a nerve, a selected one of the electrodes is configured to receive an input signal via the corresponding conductive wire and to transmit the input signal to the nerve, and each of the electrodes other than the selected one is configured to receive from the nerve a response signal associated with the input signal and to transmit the response signal via the corresponding conductive wire.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: October 6, 2020
    Assignees: Chang Gung University, Chang Gung Memorial Hospital, Linkou
    Inventors: Yu-Cheng Pei, Ting-Yu Chen, Cheng-Hung Lin, Jian-Jia Huang
  • Patent number: 10760788
    Abstract: A method of combusting a sulfur-containing carbonaceous material with ash treatment includes: feeding a feed containing the sulfur-containing carbonaceous material and limestone into a furnace; combusting the feed in the furnace so as to generate preliminary fly and bottom ashes; hydrating the preliminary fly and bottom ashes to form a hydrated material; recycling the hydrated materials into the furnace so as to generate secondary fly and bottom ashes; and reacting the secondary fly and bottom ashes with a sulfuric acid solution.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: September 1, 2020
    Assignee: CHANG GUNG UNIVERSITY
    Inventors: Hsiu-Po Kuo, An-Ni Huang
  • Patent number: 10736513
    Abstract: The present invention provides imaging devices, systems, and methods of operation for acoustic-enhanced optical coherence tomography. The systems coordinate imaging devices, optical coherence tomography (OCT), and pulsed ultrasound (FUS) and or pulsed ultrasound (PUS) to enhance the contrast of images. Moreover, the systems improve in vivo diagnosis and drug release through the utilization of sonographic enhancers such as microbubbles (MBs).
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: August 11, 2020
    Assignee: CHANG GUNG UNIVERSITY
    Inventors: Hao-Li Liu, Meng-Tsan Tsai, Chih-Kuang Yeh
  • Patent number: 10730920
    Abstract: Disclosed herein are recombinant polypeptides derived from FBP1 and FBP2. Also disclosed herein are recombinant expression vectors and recombinant host cells for producing the aforesaid recombinant polypeptides. The recombinant polypeptides are proven to be useful and effective in producing a picornavirus with a type I internal ribosome entry site (IRES), so as to facilitate the preparation of a viral vaccine.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: August 4, 2020
    Assignee: CHANG GUNG UNIVERSITY
    Inventors: Shin-Ru Shih, Yu-An Kung, Chuan-Tien Hung
  • Patent number: 10654848
    Abstract: Disclosed herein are compounds of formula (I), and pharmaceutical compositions comprising the same. The compounds of formula (I) are neutrophilic inflammation inhibitors, thus, they are useful for treatment and/or prophylaxis of inflammatory diseases and/or disorders associated with abnormal activation of neutrophils, such as ARDS, ALI, COPD, lung fibrosis, chronic bronchitis, pulmonary emphysema, ?-1 anti-trypsin deficiency, cystic fibrosis, idiopathic pulmonary fibrosis, liver injury, steatohepatitis, liver fibrosis, damages caused by ischemia and reperfusion, myocardial infarction, shock, stroke, and organ transplantation, ulcerative cholitis, vasculitis, SLE, sepsis, SIRS, arthritis, psoriasis, atopic dermatitis, and inflammatory skin diseases.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: May 19, 2020
    Assignees: Chang Gung University of Science and Technology, Chang Gung University, Kaohsiung Medical University
    Inventors: Tsong-Long Hwang, Yeh-Long Chen, Cherng-Chyi Tzeng, Chih-Hua Tseng
  • Publication number: 20200148674
    Abstract: Disclosed herein are compounds of formula (I), and pharmaceutical compositions comprising the same. The compounds of formula (I) are neutrophilic inflammation inhibitors, thus, they are useful for treatment and/or prophylaxis of inflammatory diseases and/or disorders associated with abnormal activation of neutrophils, such as ARDS, ALI, COPD, lung fibrosis, chronic bronchitis, pulmonary emphysema, ?-1 anti-trypsin deficiency, cystic fibrosis, idiopathic pulmonary fibrosis, liver injury, steatohepatitis, liver fibrosis, damages caused by ischemia and reperfusion, myocardial infarction, shock, stroke, and organ transplantation, ulcerative cholitis, vasculitis, SLE, sepsis, SIRS, arthritis, psoriasis, atopic dermatitis, and inflammatory skin diseases.
    Type: Application
    Filed: November 9, 2018
    Publication date: May 14, 2020
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long HWANG, Yeh-Long CHEN, Cherng-Chyi TZENG, Chih-Hua TSENG
  • Publication number: 20200110097
    Abstract: An immunoassay includes forming first mixtures by reacting a combination reagent with serum of a subject; simultaneously forming second mixtures by reacting randomly selected platelet samples with the serum wherein in each mixture there are immunity compounds formed by combining the platelet antigens with predetermined antibodies in the serum, and other platelet antigens and other antibodies in the serum not forming the immunity compounds; preparing an interception device including receptacles and a filter net; placing each mixture in one receptacle; washing the mixtures wherein the mixtures forming the immunity compounds are intercepted by the filter net with others passing through; adding a signal sensing reagent to each receptacle; reacting the signal sensing reagent with the intercepted mixtures forming the immunity compounds to form final products; and performing a signal sensing to determine whether the final products contain anti-platelet antibodies and determine compatibility of cross matching of resp
    Type: Application
    Filed: September 11, 2019
    Publication date: April 9, 2020
    Applicants: Chang Gung University, CHANG GUNG MEMORIAL HOSPITAL, LINKOU
    Inventors: Tzong-Shi Chiueh, Min-Hsien Wu, Hsin-Yao Wang
  • Patent number: 10598658
    Abstract: A reduced graphene oxide-based biosensor includes a nano-structure field-effect transistor including a channel region which includes a reduced graphene oxide having a linking moiety to be bonded to a receptor specific to an analyte, and which is represented by a formula of —(C?O)—X—COOH, wherein X represents a C1-C3 alkenylene group or a C1-C3 alkylene group.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: March 24, 2020
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Chien-Lun Chen