Patents Assigned to Chang Gung University
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Patent number: 12213762Abstract: A sole data collection device and a sole data collection method are disclosed. The sole data collection device includes an image capture module, a temperature detection module and a monofilament testing module. The sole data collection device is used for collecting the sole data of a user, and the sole data is transmitted to a cloud server. The sole data collection device and the sole data collection method are not only convenient for a user to collect sole data at home at any time, but also allow the user's caregiver and/or relevant medical care personnel to extract the sole data from the cloud server to screen the user's plantar condition, so as to solve the problem that it is time-consuming and costly to go to a medical institution for relevant examinations.Type: GrantFiled: March 30, 2023Date of Patent: February 4, 2025Assignee: Chang Gung UniversityInventors: Ting-Ting Yeh, Miao-Yu Liao, Chia-Chih Chang, Yu-Syuan Chen, I-Feng Hsu
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Publication number: 20250032571Abstract: An Oncidium plant extract and methods for treating diabetes mellitus, liver protection and preventing acute respiratory distress syndrome thereof are provided, the steps for extracting the Oncidium plant extract include taking an Oncidium plant sample, drying and grinding the sample to obtain a ground Oncidium plant sample, and then extracting the ground Oncidium plant sample in a solvent by an accelerated solvent extraction or an ultrasonic extraction to obtain an Oncidium plant extract.Type: ApplicationFiled: July 26, 2024Publication date: January 30, 2025Applicant: Chang Gung University of Science and TechnologyInventors: Tsong-Long Hwang, Yu-Chia Chang
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Publication number: 20250009763Abstract: Disclosed herein is related to a method for extending lifespan and/or delaying aging in a subject; the method comprises administering to the subject with an effective amount of (24S)-3?-hydroxy-5?-stigmastan-6-one, wherein the delaying aging comprises increasing vitality, muscle strength or motor coordination, insulin sensitivity, or basal metabolic rate; and/or reducing muscle weakness, loss of balance, hair graying, kyphosis, or hyperglycemia. Also encompassed in the present disclosure are methods for promoting weight loss or treating type 2 diabetes mellitus in a subject, in which the methods comprise administering to the subject an effective amount of (24S)-3?-hydroxy-5?-stigmastan-6-one.Type: ApplicationFiled: July 7, 2023Publication date: January 9, 2025Applicant: Chang Gung UniversityInventors: Chin-Chuan CHEN, Yann-Lii LEU, Chi-Yuan CHEN, Tong-Hong WANG, Shu-Fang CHENG
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Patent number: 12132448Abstract: The present invention relates to a gallium nitride transimpedance amplifier, as an essential electronic circuit in the proton beam therapy. Because gallium nitride is more tolerant to the secondary radiation generated during the proton beam therapy, it has high reliability and increases the reliability of the overall system.Type: GrantFiled: July 12, 2021Date of Patent: October 29, 2024Assignee: Chang Gung UniversityInventors: Cher-Ming Tan, Vimal Kant Pandey
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Patent number: 12097283Abstract: Disclosed herein is a method for alleviating dry eye syndrome using a composition containing a polylysine nanoparticle. The polylysine nanoparticle is produced by subjecting lysine hydrochloride to a pyrolysis treatment at a temperature ranging from 240° C. to 280° C.Type: GrantFiled: September 19, 2022Date of Patent: September 24, 2024Assignees: Chang Gung University, Giant Bio Technology Inc.Inventors: Jui-Yang Lai, Chih-Ching Huang, Han-Jia Lin, Hong-Jyuan Jian
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Patent number: 12028031Abstract: The present invention is gallium nitride based operational amplifier because reliability and performance of the gallium nitride is better than the silicon counterpart in radiation environment. The operational amplifier includes four stages, first stage is dual input balanced output differential amplifier, second stage is dual input unbalanced differential amplifier, third stage is buffer stage to couple second and fourth stage, and fourth stage is cascaded common source amplifier with degeneration. A capacitor coupled between second and third stage is to enhance the stability of operational amplifier.Type: GrantFiled: October 18, 2021Date of Patent: July 2, 2024Assignee: CHANG GUNG UNIVERSITYInventors: Cher-Ming Tan, Vimal Kant Pandey
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Patent number: 12023329Abstract: Disclosed herein is a method of treating diseases and/or disorders associated with the activation of inflammasomes. The method includes administering to a subject in need thereof an effective amount of 4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)-carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, a salt, a solvate or an ester thereof.Type: GrantFiled: August 26, 2020Date of Patent: July 2, 2024Assignee: CHANG GUNG UNIVERSITYInventors: Tsong-Long Hwang, Ya-Xuan Wang
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Publication number: 20240159752Abstract: Disclosed herein is a method for determining whether a subject has or is at risk of developing colorectal cancer with an ex vivo biological sample isolated from the subject. The method comprises: determining the levels of at least two target proteins with the aid of mass spectrometry, in which the at least two target proteins are selected from the group consisting of ADAM10, CD59, and TSPAN9; and assessing whether the subject has or is at risk of developing the colorectal cancer based on the levels of the at least two target proteins. The present method may serve as a potential means for diagnosing and predicting the incidence of colorectal cancer, and the subject in need thereof could receive a suitable therapeutic regimen in time in accordance with the diagnostic results produced by the present method.Type: ApplicationFiled: February 20, 2023Publication date: May 16, 2024Applicant: Chang Gung UniversityInventors: Jau-Song YU, Srinivas DASH, Chia-Chun WU, Sheng-Fu CHIANG, Yu-Ting LU
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Patent number: 11969739Abstract: A method for performing contactless ODEP for separation of CTCs is provided with the steps of obtaining patients' blood with rare cell suspected CTCs; adding at least one fluorescent antibody binding to CTCs into the blood; staining the blood; injecting the stained blood with fluorescent dye into an ODEP device and then performing fluorescent image identification; trapping the CTCs with at least one fluorescent antibody in the ODEP device by creating an image pattern and then generating an ODEP force; Separating the trapped CTCs from other non-CTCs cells; absorbing the trapped CTCs; and obtaining a high purity of CTCs. An apparatus for performing contactless ODEP for separation of CTCs is also provided.Type: GrantFiled: September 20, 2019Date of Patent: April 30, 2024Assignee: Chang Gung UniversityInventor: Min-Hsien Wu
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Publication number: 20240123017Abstract: A method for promoting chronic wound healing is provided, including administering an effective amount of Bletilla formosana (Hayata) Schltr. extract to a subject in need thereof, wherein the effective amount of Bletilla formosana (Hayata) Schltr. extract is 0.01 mg/kg-body weight to 100 mg/kg-body weight, and wherein the chronic wound including diabetic wound and Diabetic Foot Ulcer.Type: ApplicationFiled: October 5, 2023Publication date: April 18, 2024Applicant: Chang Gung University of Science and TechnologyInventors: Tsong-Long Hwang, Yu-Chia Chang
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Publication number: 20240091191Abstract: Disclosed herein is related to a method for treating a symptom associated with senescence in a subject by administering to the subject with an effective amount of corylin and/or neobavaisoflavone, wherein the symptom associated with senescence is loss of muscle strength, muscle weakness, loss of motor coordination, loss of balance, skin wrinkle, or a poor blood biochemical parameter.Type: ApplicationFiled: September 2, 2022Publication date: March 21, 2024Applicant: Chang Gung UniversityInventors: Chin-Chuan CHEN, Yann-Lii LEU, Shu-Huei WANG, Tong-Hong WANG, Shu-Fang CHENG
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Patent number: 11931187Abstract: A method for predicting clinical severity of a neurological disorder includes steps of: a) identifying, according to a magnetic resonance imaging (MRI) image of a brain, brain image regions each of which contains a respective portion of diffusion index values of a diffusion index, which results from image processing performed on the MRI image; b) for one of the brain image regions, calculating a characteristic parameter based on the respective portion of the diffusion index values; and c) calculating a severity score that represents the clinical severity of the neurological disorder of the brain based on the characteristic parameter of the one of the brain image regions via a prediction model associated with the neurological disorder.Type: GrantFiled: March 16, 2018Date of Patent: March 19, 2024Assignees: Chang Gung Medical Foundation Chang Gung Memorial Hospital at Keelung, Chang Gung Memorial Hospital, Linkou, Chang Gung UniversityInventors: Jiun-Jie Wang, Yi-Hsin Weng, Shu-Hang Ng, Jur-Shan Cheng, Yi-Ming Wu, Yao-Liang Chen, Wey-Yil Lin, Chin-Song Lu, Wen-Chuin Hsu, Chia-Ling Chen, Yi-Chun Chen, Sung-Han Lin, Chih-Chien Tsai
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Patent number: 11911663Abstract: A training device and a training method for reducing hypertonic are disclosed. The training device includes a base, a driving circuit, two pedals, a control circuit, and a switch circuit. The driving circuit is fixed on the base. Each of the two pedals is coupled to the base. The driving circuit drives each of the two pedals to swing repeatedly between a first position and a second position relative to the base. When the control circuit executes a training program, the control circuit actuates the driving circuit.Type: GrantFiled: March 23, 2022Date of Patent: February 27, 2024Assignee: CHANG GUNG UNIVERSITYInventors: Ya-Ju Chang, Hsiao-Lung Chan, Jiunn-Woei Liaw, Cheng-Chung Kuo
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Patent number: 11903735Abstract: An apparatus and method for examining an organism surface includes a pliable member including a contact layer, a plurality of channels, and a reaction layer, wherein the plurality of channels are disposed between the contact layer and the reaction layer; each of the channels having a size in the range of micrometers and formed of biocompatibility materials, and the contact layer including a plurality of spherical projections having a size in the range of micrometers and formed of biocompatible materials, and the reaction layer including examining molecules and a reaction unit.Type: GrantFiled: April 30, 2021Date of Patent: February 20, 2024Assignees: CHANG GUNG UNIVERSITY, CHANG GUNG MEMORIAL HOSPITAL, LINKOUInventors: Hsin-Yao Wang, Ting-Wei Lin, Jang-Jih Lu
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Patent number: 11839610Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, comprising administering an effective amount of plant extract, wherein the plant extract comprises an alcohol extract of the herbal of Menispermaceae, wherein the herbal of Menispermaceae is Stephania cepharantha or Stephania tetrandra.Type: GrantFiled: June 10, 2022Date of Patent: December 12, 2023Assignees: CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY, CHANG GUNG UNIVERSITYInventors: Tsong-Long Hwang, Yu-Li Chen, Yu-Chia Chang
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Publication number: 20230390351Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, including administering to the subject a compound, wherein the compound comprises Aromoline, Obamegine, Berbamine or Bersavine.Type: ApplicationFiled: January 16, 2023Publication date: December 7, 2023Applicant: Chang Gung University of Science and TechnologyInventors: Tsong-Long Hwang, Yu-Li Chen, Michal Korinek, Marcela Safratova, Anna Hostalkova
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Publication number: 20230364011Abstract: Disclosed herein is a method for alleviating dry eye syndrome using a composition containing a polylysine nanoparticle. The polylysine nanoparticle is produced by subjecting lysine hydrochloride to a pyrolysis treatment at a temperature ranging from 240° C. to 280° C.Type: ApplicationFiled: September 19, 2022Publication date: November 16, 2023Applicant: Chang Gung UniversityInventors: Jui-Yang Lai, Chih-Ching Huang, Han-Jia Lin, Hong-Jyuan Jian
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Patent number: 11806088Abstract: A method includes providing medical images of a subject for selecting a target image from thereamong, building a 3D image model based on the medical images and the target image with a surgical target site assigned, performing image registration to superimpose the 3D image model on a real-time image of the subject so as to result in a combined image, determining a virtual entry site located on the combined image, connecting the surgical target site and the virtual entry site with a straight line, generating a guiding path extending from the virtual entry site, in a direction away from the surgical target site and along the straight line, and displaying the guiding path for guiding a surgical instrument.Type: GrantFiled: March 30, 2021Date of Patent: November 7, 2023Assignees: CHANG GUNG UNIVERSITY, CHANG GUNG MEMORIAL HOSPITAL, KEELUNGInventors: Shin-Yan Chiou, Pin-Yuan Chen, Hao-Li Liu, Kuo-Chen Wei
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Publication number: 20230321078Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, comprising administering an effective amount of plant extract, wherein the plant extract comprises an alcohol extract of the herbal of Menispermaceae, wherein the herbal of Menispermaceae is Stephania cepharantha or Stephania tetrandra.Type: ApplicationFiled: June 10, 2022Publication date: October 12, 2023Applicant: Chang Gung University of Science and TechnologyInventors: Tsong-Long Hwang, Yu-Li Chen, Yu-Chia Chang
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Patent number: 11744765Abstract: A standing training mobile device for carrying a patient to perform active-assisted upright locomotion is provided. The standing training mobile device includes a base, a mobile module, a lifting module, a control module, and a support module. The mobile module and the lifting module are disposed on the base. The control module is disposed on the lifting module and is coupled to the mobile module. The control module includes a manipulation platform and two control assemblies disposed on the manipulation platform for use of the patient. The support module includes a support frame, a first support assembly, a second support assembly, and a third support assembly. The first support assembly, the second support assembly, and the third support assembly are slidably disposed on the support frame respectively. The second support assembly is disposed between the first support assembly and the third support assembly.Type: GrantFiled: December 19, 2019Date of Patent: September 5, 2023Assignees: CHANG GUNG UNIVERSITY, NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Wen-Yu Liu, Hen-Yu Lien, Chung-Hsien Kuo, Yang-Hua Lin