Patents Assigned to Chang Gung University
  • Patent number: 12274704
    Abstract: A method for inhibiting inflammatory in a subject is provided, comprising: administering a pharmaceutical composition comprising an effective amount of 9,11-secosteroids.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: April 15, 2025
    Assignee: Chang Gung University of Science and Technology
    Inventors: Tsong-Long Hwang, Yu-Chia Chang, Kuei-Hung Lai
  • Patent number: 12213762
    Abstract: A sole data collection device and a sole data collection method are disclosed. The sole data collection device includes an image capture module, a temperature detection module and a monofilament testing module. The sole data collection device is used for collecting the sole data of a user, and the sole data is transmitted to a cloud server. The sole data collection device and the sole data collection method are not only convenient for a user to collect sole data at home at any time, but also allow the user's caregiver and/or relevant medical care personnel to extract the sole data from the cloud server to screen the user's plantar condition, so as to solve the problem that it is time-consuming and costly to go to a medical institution for relevant examinations.
    Type: Grant
    Filed: March 30, 2023
    Date of Patent: February 4, 2025
    Assignee: Chang Gung University
    Inventors: Ting-Ting Yeh, Miao-Yu Liao, Chia-Chih Chang, Yu-Syuan Chen, I-Feng Hsu
  • Publication number: 20250032571
    Abstract: An Oncidium plant extract and methods for treating diabetes mellitus, liver protection and preventing acute respiratory distress syndrome thereof are provided, the steps for extracting the Oncidium plant extract include taking an Oncidium plant sample, drying and grinding the sample to obtain a ground Oncidium plant sample, and then extracting the ground Oncidium plant sample in a solvent by an accelerated solvent extraction or an ultrasonic extraction to obtain an Oncidium plant extract.
    Type: Application
    Filed: July 26, 2024
    Publication date: January 30, 2025
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long Hwang, Yu-Chia Chang
  • Publication number: 20250009763
    Abstract: Disclosed herein is related to a method for extending lifespan and/or delaying aging in a subject; the method comprises administering to the subject with an effective amount of (24S)-3?-hydroxy-5?-stigmastan-6-one, wherein the delaying aging comprises increasing vitality, muscle strength or motor coordination, insulin sensitivity, or basal metabolic rate; and/or reducing muscle weakness, loss of balance, hair graying, kyphosis, or hyperglycemia. Also encompassed in the present disclosure are methods for promoting weight loss or treating type 2 diabetes mellitus in a subject, in which the methods comprise administering to the subject an effective amount of (24S)-3?-hydroxy-5?-stigmastan-6-one.
    Type: Application
    Filed: July 7, 2023
    Publication date: January 9, 2025
    Applicant: Chang Gung University
    Inventors: Chin-Chuan CHEN, Yann-Lii LEU, Chi-Yuan CHEN, Tong-Hong WANG, Shu-Fang CHENG
  • Patent number: 12132448
    Abstract: The present invention relates to a gallium nitride transimpedance amplifier, as an essential electronic circuit in the proton beam therapy. Because gallium nitride is more tolerant to the secondary radiation generated during the proton beam therapy, it has high reliability and increases the reliability of the overall system.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: October 29, 2024
    Assignee: Chang Gung University
    Inventors: Cher-Ming Tan, Vimal Kant Pandey
  • Patent number: 12097283
    Abstract: Disclosed herein is a method for alleviating dry eye syndrome using a composition containing a polylysine nanoparticle. The polylysine nanoparticle is produced by subjecting lysine hydrochloride to a pyrolysis treatment at a temperature ranging from 240° C. to 280° C.
    Type: Grant
    Filed: September 19, 2022
    Date of Patent: September 24, 2024
    Assignees: Chang Gung University, Giant Bio Technology Inc.
    Inventors: Jui-Yang Lai, Chih-Ching Huang, Han-Jia Lin, Hong-Jyuan Jian
  • Publication number: 20240159752
    Abstract: Disclosed herein is a method for determining whether a subject has or is at risk of developing colorectal cancer with an ex vivo biological sample isolated from the subject. The method comprises: determining the levels of at least two target proteins with the aid of mass spectrometry, in which the at least two target proteins are selected from the group consisting of ADAM10, CD59, and TSPAN9; and assessing whether the subject has or is at risk of developing the colorectal cancer based on the levels of the at least two target proteins. The present method may serve as a potential means for diagnosing and predicting the incidence of colorectal cancer, and the subject in need thereof could receive a suitable therapeutic regimen in time in accordance with the diagnostic results produced by the present method.
    Type: Application
    Filed: February 20, 2023
    Publication date: May 16, 2024
    Applicant: Chang Gung University
    Inventors: Jau-Song YU, Srinivas DASH, Chia-Chun WU, Sheng-Fu CHIANG, Yu-Ting LU
  • Patent number: 11969739
    Abstract: A method for performing contactless ODEP for separation of CTCs is provided with the steps of obtaining patients' blood with rare cell suspected CTCs; adding at least one fluorescent antibody binding to CTCs into the blood; staining the blood; injecting the stained blood with fluorescent dye into an ODEP device and then performing fluorescent image identification; trapping the CTCs with at least one fluorescent antibody in the ODEP device by creating an image pattern and then generating an ODEP force; Separating the trapped CTCs from other non-CTCs cells; absorbing the trapped CTCs; and obtaining a high purity of CTCs. An apparatus for performing contactless ODEP for separation of CTCs is also provided.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: April 30, 2024
    Assignee: Chang Gung University
    Inventor: Min-Hsien Wu
  • Publication number: 20240123017
    Abstract: A method for promoting chronic wound healing is provided, including administering an effective amount of Bletilla formosana (Hayata) Schltr. extract to a subject in need thereof, wherein the effective amount of Bletilla formosana (Hayata) Schltr. extract is 0.01 mg/kg-body weight to 100 mg/kg-body weight, and wherein the chronic wound including diabetic wound and Diabetic Foot Ulcer.
    Type: Application
    Filed: October 5, 2023
    Publication date: April 18, 2024
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long Hwang, Yu-Chia Chang
  • Publication number: 20240091191
    Abstract: Disclosed herein is related to a method for treating a symptom associated with senescence in a subject by administering to the subject with an effective amount of corylin and/or neobavaisoflavone, wherein the symptom associated with senescence is loss of muscle strength, muscle weakness, loss of motor coordination, loss of balance, skin wrinkle, or a poor blood biochemical parameter.
    Type: Application
    Filed: September 2, 2022
    Publication date: March 21, 2024
    Applicant: Chang Gung University
    Inventors: Chin-Chuan CHEN, Yann-Lii LEU, Shu-Huei WANG, Tong-Hong WANG, Shu-Fang CHENG
  • Patent number: 11931187
    Abstract: A method for predicting clinical severity of a neurological disorder includes steps of: a) identifying, according to a magnetic resonance imaging (MRI) image of a brain, brain image regions each of which contains a respective portion of diffusion index values of a diffusion index, which results from image processing performed on the MRI image; b) for one of the brain image regions, calculating a characteristic parameter based on the respective portion of the diffusion index values; and c) calculating a severity score that represents the clinical severity of the neurological disorder of the brain based on the characteristic parameter of the one of the brain image regions via a prediction model associated with the neurological disorder.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: March 19, 2024
    Assignees: Chang Gung Medical Foundation Chang Gung Memorial Hospital at Keelung, Chang Gung Memorial Hospital, Linkou, Chang Gung University
    Inventors: Jiun-Jie Wang, Yi-Hsin Weng, Shu-Hang Ng, Jur-Shan Cheng, Yi-Ming Wu, Yao-Liang Chen, Wey-Yil Lin, Chin-Song Lu, Wen-Chuin Hsu, Chia-Ling Chen, Yi-Chun Chen, Sung-Han Lin, Chih-Chien Tsai
  • Publication number: 20230390351
    Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, including administering to the subject a compound, wherein the compound comprises Aromoline, Obamegine, Berbamine or Bersavine.
    Type: Application
    Filed: January 16, 2023
    Publication date: December 7, 2023
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long Hwang, Yu-Li Chen, Michal Korinek, Marcela Safratova, Anna Hostalkova
  • Publication number: 20230364011
    Abstract: Disclosed herein is a method for alleviating dry eye syndrome using a composition containing a polylysine nanoparticle. The polylysine nanoparticle is produced by subjecting lysine hydrochloride to a pyrolysis treatment at a temperature ranging from 240° C. to 280° C.
    Type: Application
    Filed: September 19, 2022
    Publication date: November 16, 2023
    Applicant: Chang Gung University
    Inventors: Jui-Yang Lai, Chih-Ching Huang, Han-Jia Lin, Hong-Jyuan Jian
  • Publication number: 20230321078
    Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, comprising administering an effective amount of plant extract, wherein the plant extract comprises an alcohol extract of the herbal of Menispermaceae, wherein the herbal of Menispermaceae is Stephania cepharantha or Stephania tetrandra.
    Type: Application
    Filed: June 10, 2022
    Publication date: October 12, 2023
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long Hwang, Yu-Li Chen, Yu-Chia Chang
  • Patent number: 11679102
    Abstract: Disclosed herein is a method for inhibiting virus infection, including administering to a subject in need thereof an effective amount of a ferroptosis inhibitor or a pharmaceutically acceptable salt thereof. Also disclosed is a method for inhibiting viral replication, including contacting a virus with a ferroptosis inhibitor or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: June 20, 2023
    Assignee: Chang Gung University
    Inventors: Shin-Ru Shih, Yu-An Kung, Huan-Jung Chiang, Chuan-Tien Hung, Yu-Nong Gong, Hsin-Ping Chiu, Chiung-Guei Huang, Peng-Nien Huang, Sheng-Yu Huang
  • Publication number: 20230030454
    Abstract: Disclosed herein is a method for identifying and treating a Streptococcus pyogenes (group A Streptococcus, GAS) infection in a subject. The method mainly includes determining the presence of endopeptidase O (PepO) protein in the biological sample; and administering an effective amount of an anti-infective agent to the subject to ameliorate symptoms associated with the GAS infection if the PepO protein is present in the biological sample.
    Type: Application
    Filed: July 27, 2021
    Publication date: February 2, 2023
    Applicant: Chang Gung University
    Inventor: Chuan CHIANG-NI
  • Publication number: 20220339122
    Abstract: Disclosed herein is a method of treating diseases and/or disorders associated with the dysregulated activation and recruitment of neutrophils. The method includes administering to a subject in need thereof an effective amount of 3,3?-dihydroxy-2?,6?-bis(p-hydroxybenzyl)-5-methoxybibenzyl (or bletinib), a salt, a solvate or an ester thereof.
    Type: Application
    Filed: April 27, 2021
    Publication date: October 27, 2022
    Applicant: Chang Gung University
    Inventors: Tsong-Long HWANG, Ting-I KAO, Tian-Shung WU
  • Patent number: 11363968
    Abstract: A center of pressure (CoP) based control system includes a sensing device and an electronic device connected to the sensing device. The sensing device includes sensors each of which continuously measures force exerted thereon by a subject and generates a sense signal based on a result of the measurement. The electronic device is connected to the sensing device, and receives the sense signals from the respective sensors, generates CoP data associated with a CoP trajectory based on the sense signals, determines whether a turning point exists in the CoP trajectory, generates an indication signal based on a result of the determination, and generates a control signal based on a direction of one of displacements of the CoP.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: June 21, 2022
    Assignee: Chang Gung University
    Inventors: Ya-Ju Chang, Jiunn-Woei Liaw, Hung-Bin Chen
  • Publication number: 20220146527
    Abstract: A method of creating characteristic profiles of mass spectra and identification model for analyzing and identifying microorganisms includes collecting m/z data of microorganisms having same features from MALDI-TOF MS; classifying the microorganisms; classifying the collected set of m/z data as a plurality of subsets; creating modified subsets by applying KDE to the subsets; creating first characteristic MS profiles based on the modified subsets; summarizing into a second characteristic MS profile; repeating above six steps to create second characteristic MS profiles; creating a training set comprising first matched vectors; training a machine learning system using the training set to establish a feature classification model; using MALDI-TOF MS to analyze microorganisms having unknown features; comparing m/z of MALDI-TOF MS spectrum of the microorganisms having unknown features with second characteristic MS profiles to obtain second matched vectors; using the feature classification model analyzing the second m
    Type: Application
    Filed: January 25, 2022
    Publication date: May 12, 2022
    Applicant: Chang Gung University
    Inventors: Jang-Jih Lu, Hsin-Yao Wang, Chia-Ru Chung, Jorng-Tzong Horng, Tzong-Yi Lee
  • Patent number: 11328791
    Abstract: A method for determining a human subject's risk of developing acute kidney injury (AKI) from acute myocardial infarction (AMI) includes: obtaining a blood sample; determining at least two miRNA expression levels therein, which are selected from miR-23a-3p, miR-24-3p, and miR-145-5p expression levels; calculating probability of developing AKI from AMI based on the at least two miRNA expression levels and a logistic regression model; comparing the probability with a predetermined standard; and determining that the human subject is at the risk of developing AKI when the probability is higher than the predetermined standard. A composition may be administered to the human subject for inhibiting development of AKI, if any.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: May 10, 2022
    Assignees: Chang Gung University, Chang Gung Memorial Hospital, Linkou
    Inventors: Pao-Hsien Chu, Yu-Sun Chang, Chia-Chun Chen, Pei-Chun Fan