Patents Assigned to Chang Gung University of Science and Technology
  • Publication number: 20240123017
    Abstract: A method for promoting chronic wound healing is provided, including administering an effective amount of Bletilla formosana (Hayata) Schltr. extract to a subject in need thereof, wherein the effective amount of Bletilla formosana (Hayata) Schltr. extract is 0.01 mg/kg-body weight to 100 mg/kg-body weight, and wherein the chronic wound including diabetic wound and Diabetic Foot Ulcer.
    Type: Application
    Filed: October 5, 2023
    Publication date: April 18, 2024
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long Hwang, Yu-Chia Chang
  • Patent number: 11839610
    Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, comprising administering an effective amount of plant extract, wherein the plant extract comprises an alcohol extract of the herbal of Menispermaceae, wherein the herbal of Menispermaceae is Stephania cepharantha or Stephania tetrandra.
    Type: Grant
    Filed: June 10, 2022
    Date of Patent: December 12, 2023
    Assignees: CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY, CHANG GUNG UNIVERSITY
    Inventors: Tsong-Long Hwang, Yu-Li Chen, Yu-Chia Chang
  • Publication number: 20230390351
    Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, including administering to the subject a compound, wherein the compound comprises Aromoline, Obamegine, Berbamine or Bersavine.
    Type: Application
    Filed: January 16, 2023
    Publication date: December 7, 2023
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long Hwang, Yu-Li Chen, Michal Korinek, Marcela Safratova, Anna Hostalkova
  • Publication number: 20230321078
    Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, comprising administering an effective amount of plant extract, wherein the plant extract comprises an alcohol extract of the herbal of Menispermaceae, wherein the herbal of Menispermaceae is Stephania cepharantha or Stephania tetrandra.
    Type: Application
    Filed: June 10, 2022
    Publication date: October 12, 2023
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long Hwang, Yu-Li Chen, Yu-Chia Chang
  • Publication number: 20220040199
    Abstract: A method for inhibiting inflammatory in a subject is provided, comprising: administering a pharmaceutical composition comprising an effective amount of 9,11-secosteroids.
    Type: Application
    Filed: April 28, 2021
    Publication date: February 10, 2022
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long Hwang, Yu-Chia Chang, Kuei-Hung Lai
  • Patent number: 10654848
    Abstract: Disclosed herein are compounds of formula (I), and pharmaceutical compositions comprising the same. The compounds of formula (I) are neutrophilic inflammation inhibitors, thus, they are useful for treatment and/or prophylaxis of inflammatory diseases and/or disorders associated with abnormal activation of neutrophils, such as ARDS, ALI, COPD, lung fibrosis, chronic bronchitis, pulmonary emphysema, ?-1 anti-trypsin deficiency, cystic fibrosis, idiopathic pulmonary fibrosis, liver injury, steatohepatitis, liver fibrosis, damages caused by ischemia and reperfusion, myocardial infarction, shock, stroke, and organ transplantation, ulcerative cholitis, vasculitis, SLE, sepsis, SIRS, arthritis, psoriasis, atopic dermatitis, and inflammatory skin diseases.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: May 19, 2020
    Assignees: Chang Gung University of Science and Technology, Chang Gung University, Kaohsiung Medical University
    Inventors: Tsong-Long Hwang, Yeh-Long Chen, Cherng-Chyi Tzeng, Chih-Hua Tseng
  • Publication number: 20200148674
    Abstract: Disclosed herein are compounds of formula (I), and pharmaceutical compositions comprising the same. The compounds of formula (I) are neutrophilic inflammation inhibitors, thus, they are useful for treatment and/or prophylaxis of inflammatory diseases and/or disorders associated with abnormal activation of neutrophils, such as ARDS, ALI, COPD, lung fibrosis, chronic bronchitis, pulmonary emphysema, ?-1 anti-trypsin deficiency, cystic fibrosis, idiopathic pulmonary fibrosis, liver injury, steatohepatitis, liver fibrosis, damages caused by ischemia and reperfusion, myocardial infarction, shock, stroke, and organ transplantation, ulcerative cholitis, vasculitis, SLE, sepsis, SIRS, arthritis, psoriasis, atopic dermatitis, and inflammatory skin diseases.
    Type: Application
    Filed: November 9, 2018
    Publication date: May 14, 2020
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long HWANG, Yeh-Long CHEN, Cherng-Chyi TZENG, Chih-Hua TSENG
  • Patent number: 9855346
    Abstract: Compositions comprising one or more nanoparticles, wherein the nanoparticles encapsulate fluorescence dyes are disclosed. In one embodiment, the nanoparticle comprises triterpene. In another embodiment, the nanoparticle comprises triterpene and fatty ester. Methods for performing a diagnostic or a therapeutic procedure comprising administering to a subject an effective amount of the compositions of the present invention or carbocyanine dyes are also provided.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: January 2, 2018
    Assignee: Chang Gung University of Science and Technology
    Inventors: Chia-Yu Fang, Chih-Jen Wen