Patents Assigned to CHANNELOSEARCH TECHNOLOGY
  • Material for screening for compound acting on ION channel and use thereof
    Patent number: 11828750
    Abstract: A screening system provided with a potential-dependent Na ion channel that extends the duration of the action potential associated with depolarization, and a K ion channel that deepens the resting membrane potential in the negative direction, said screening system furthermore including cells provided with ion channels that contribute to deepening the resting membrane potential in the negative direction and/or shortening the duration of the action potential as target ion channels. By such cells, the action of a test compound on the target ion channel can be easily evaluated by providing an inhibitor for the K ion channel to control the probability of cell death.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: November 28, 2023
    Assignees: PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY, CHANNELOSEARCH TECHNOLOGY
    Inventors: Yuji Imaizumi, Hisao Yamamura, Yoshiaki Suzuki, Keisuke Kawasaki, Hiroshi Narita
  • Material for Screening For Compound Acting on ION Channel and Use Thereof
    Publication number: 20190331664
    Abstract: A screening system provided with a potential-dependent Na ion channel that extends the duration of the action potential associated with depolarization, and a K ion channel that deepens the resting membrane potential in the negative direction, said screening system furthermore including cells provided with ion channels that contribute to deepening the resting membrane potential in the negative direction and/or shortening the duration of the action potential as target ion channels. By such cells, the action of a test compound on the target ion channel can be easily evaluated by providing an inhibitor for the K ion channel to control the probability of cell death.
    Type: Application
    Filed: November 1, 2017
    Publication date: October 31, 2019
    Applicants: PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY, CHANNELOSEARCH TECHNOLOGY
    Inventors: Yuji IMAIZUMI, Hisao YAMAMURA, Yoshiaki SUZUKI, Keisuke KAWASAKI, Hiroshi NARITA
  • Material for screening for compound acting on ion channel and use thereof
    Patent number: 9133496
    Abstract: An object of the present invention is to provide a screening system that targets ion channels and has superior efficiency. The present invention provides a material for screening for compounds that act on a target ion channel, comprising cells which retain at least one first DNA encoding a voltage-dependent Na ion channel that has been inhibited from being inactivated, and in which a K ion channel has been activated so that a resting membrane potential becomes deeper in a negative direction.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: September 15, 2015
    Assignees: PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY, CHANNELOSEARCH TECHNOLOGY
    Inventors: Yuji Imaizumi, Masato Fujii, Susumu Ohya, Hisao Yamamura
  • MATERIAL FOR SCREENING FOR COMPOUND ACTING ON ION CHANNEL AND USE THEREOF
    Publication number: 20130183709
    Abstract: An object of the present invention is to provide a screening system that targets ion channels and has superior efficiency. The present invention provides a material for screening for compounds that act on a target ion channel, comprising cells which retain at least one first DNA encoding a voltage-dependent Na ion channel that has been inhibited from being inactivated, and in which a K ion channel has been activated so that a resting membrane potential becomes deeper in a negative direction.
    Type: Application
    Filed: June 29, 2011
    Publication date: July 18, 2013
    Applicants: CHANNELOSEARCH TECHNOLOGY, PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY
    Inventors: Yuji Imaizumi, Masato Fujii, Susumu Ohya, Hisao Yamamura