Abstract: Disclosed are high throughput assay systems and methods for identifying agents that alter the level of surface expression of integral membrane proteins, such as cardiac ion channels, in mammalian cells. Also disclosed are therapeutic methods of using agents identified using such methods.
Type:
Grant
Filed:
August 6, 2003
Date of Patent:
May 1, 2007
Assignee:
Chan Test, Inc.
Inventors:
Arthur M. Brown, Eckhard Ficker, Barbara A. Wible