Abstract: The present invention concerns means and methods for cancer diagnosis and, in particular, diagnosis of prostate cancer. Specifically, it relates to a method for diagnosing whether a subject is at risk for recunent prostate carcinoma after prostatectomy comprising determining the amount of at least one metabolite selected from Table 2 in a test sample of a subject after prostatectomy, and comparing the determined amount to a reference, whereby it is diagnosed whether the subject is at risk for recurrent prostate carcinoma after prostatectomy. Further methods provided in accordance with the present invention relate to differentiating between a malignant prostate carcinoma tissue and a non-malignant tissue and diagnosing metastasizing prostate carcinoma in a subject. Also provided are devices for carrying out the aforementioned methods.

Abstract: The invention relates to an agent for treating cervical dysplasias, comprising a recombinant, genetically modified E1-deleted adenovirus replication defective in non-HPV infected cells, which is suitable for local external application in the region of the portio and the cervix uteri.

Abstract: The invention provides antibody against p40, IL-12 or IL-23 for the prevention or treatment of Alzheimer's disease. It further provides ligands to the pair of interleukin 12 or 23 and its specific receptor, specifically an antibody, an antibody fragment, an antibody-like-molecule, for the prevention or treatment of Alzheimer's disease. Similarly, siRNA, antisense or transcription factor modulators of gene expression of p19, p35, p40, IL-12R-?1, IL-12R-?2, and/or IL-23R for the prevention or treatment of Alzheimer's disease are provided.

Abstract: The present invention relates to an X-ray system and method for generating 3D image data. The X-ray system comprises a radiation detector, a movable X-ray tube assembly and a control unit, wherein in a working state of the system the radiation detector is detachably positioned in a spatially fixed manner and the X-ray tube assembly can be moved into relative positions relative to the radiation detector. Projection images recorded in the relative positions can be processed together with the coordinates of the relative positions using an iterative reconstruction technique or other image processing methods so as to obtain 3D X-ray images. The X-ray tube assembly is attached to a motor-driven movable stand arm and can be displaced using a control unit. The stand base of the movable stand can be positioned in a spatially fixed manner, so that it has a defined fixed position relative to the radiation detector.

Abstract: The invention relates to new uses of soluble CEACAM6 or CEACAM8, or substances that are specific to soluble CEACAM8. Another object of the invention concerns the use of CEACAM1-specific and/or CEACAM6-specific compounds for apoptosis prevention in-vitro. The invention also relates to a method for screening compounds, which prevent apoptosis and a method for preventing apoptosis in human granulocytes.

Abstract: The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.

Abstract: The invention relates to an agent for treating cervical dysplasias, comprising a recombinant, genetically modified E1-deleted adenovirus replication defective in non-HPV infected cells, which is suitable for local external application in the region of the portio and the cervix uteri.

Abstract: The application provides Ang-(1-7) receptor agonist peptides and their use for treating acute lung injury.

Abstract: The invention relates to an apparatus for the uniform distribution of microparticles in a liquid, said apparatus comprising a storage chamber 1 including a suspension of microparticles and liquid, a mixing head 2 for receiving the suspension, and a pump 3 which is connected to the storage chamber 1 and the mixing head 2 for sucking the suspension from the storage chamber 1 into the mixing head 2, said mixing head 2 having at least one well 4 with a flow turbulator 5 and an overflow 6 which is connected to the storage chamber 1 via an opening 7, characterized in that the storage chamber 1 has a pin 14 and/or a rotary inlet 15 and a rotary runback 16 which are connected to the pump 3. The apparatus can be used for the identification, characterization and purification of proteins. The invention is also directed to a method for the uniform distribution of microparticles in a liquid, which method generates a turbulent, quasi-static state.

Abstract: The invention relates to a device to produce mechanical oscillations in a research object using magnetic resonance elastography (MRE) with a membrane that can be set into periodic motion (312) and a transmission element (4, 400) for the transmission of periodic motion of the membrane (312) onto the research object (1), whereby the membrane (312) is connected to the transmission element (4, 400) by means of a mounting medium (311, 320, 321, 322) in such a way that periodic motion of the membrane is transmitted over the mounting medium (311, 320, 321, 322) to the transmission element (4, 400). A second aspect relates to the invention of a device with a step motor to generate periodic motion and a transmission element for the transmission of the periodic motion of the step motor to the research object in order to generate mechanical oscillation therein.

Abstract: A DNA polynucleotide sequence is disclosed that comprises a transcribed sequence, and a promoter sequence. Transcription of the transcribed sequence by an RNA polymerase in a cell renders an RNA a transcript capable of forming a partially self-complementary hairpin structure which can be processed by the cell to an siRNA product that can degrade phospholamban mRNA in such cell. The promoter is a drug inducible conditional promoter or a cardiomyocyte cell-specific promoter or both, operably linked to the transcribed sequence. The promoter is operable by an RNA polymerase naturally occurring in a mammalian cell.

Abstract: The present invention relates to a viral vector system comprising at least one viral vector and at least one regulable expression cassette inserted in said viral vector applicable for the treatment of virally infected cells. Preferably, the at least one regulable expression cassette comprises at least one transactivator, at least one promoter and at least one nucleotide sequence coding for a transgene, preferably a fusion protein. The present invention also relates to a composition comprising said viral vector and antiviral siRNAs for treatment of virally infected cells.

Abstract: The invention relates to an analysis method for determining a functional parameter of an organ of a human or animal individual by measuring the 13CO2 content in the air exhaled by the individual to which a substrate has been administered the reaction of which in the body of the individual enriches the air exhaled by the individual with 13CO2. The method is characterized by using a measuring device, the maximum reaction rate of the substrate in the body of the individual being determined via a change of the measured 13CO2 content in the air exhaled by the individual using zero-order enzyme kinetics. The invention also relates to an aqueous methacetin solution for use in said analysis method, the pH of the solution being greater 7.0. The invention also relates to a face mask (1) for use in the inventive method for separating the exhaled air from the air inhaled by an individual. Said face mask comprises a face mask body (2) and an air cushion (3) encircling the face mask body.

Abstract: The invention relates to an apparatus for spectroscopically analysing a gas, said apparatus having at least one radiation source (1), at least one detection apparatus (12; 20), at least one sample chamber (13) and a system of optical elements (4; 5; 6; 7; 9; 10; 11; 18; 19) which is intended and set up to direct at least part (3b) of the radiation (3) emitted by the radiation source (1) through the sample chamber (13) onto the detection apparatus (20), wherein the sample chamber (13) is used to hold a gaseous sample which contains the gas to be analysed, and wherein the apparatus is configured in such a manner that the sample can continuously flow through the sample chamber (13), and means (16) are provided for the purpose of determining the pressure and/or the volume and/or the concentration of the sample in the sample chamber (13). The invention also relates to a corresponding method for spectroscopically analysing a gas.

Abstract: The invention relates to new side chain-fluorinated 3?-deoxythymidine derivatives of the general formula I or physiological acceptable esters thereof, wherein R?CH218F; CH18F2; CH2F or CHF2 and Y?H, N3 or Hal. The invention also relates to a simple and efficient method for the preparation of these 3?-deoxythymidines of formula I and to the use of the 18F-containing compounds of formula I or of a pharmaceutical composition comprising these compounds for the diagnosis of tumors in positron emission tomography (PET).

Abstract: The invention relates to novel biosynthetic growth factor mutants which exhibit improved biological activity.

Abstract: The present invention relates to the use of a substance or composition comprising one or more proteasome inhibitors for the manufacture of a medicament for the treatment of an individual infected with a virus selected from the group comprising varicella zoster virus, human cytomegalovirus, human herpesvirus 6 and 7 and Epstein-Barr virus and Karposi's sarcoma herpesvirus. The invention further relates to methods of treatment of individuals infected with a virus selected from the group comprising varicella zoster virus, human cytomegalovirus, human herpesvirus 6 and 7 and Epstein-Barr virus and Karposi's sarcoma herpesvirus.

Abstract: The present invention relates to the use of a proteasome inhibitor for the manufacture of a medicament for the prevention, onset therapy, acute therapy and/or regression of diseases associated with endothelial dysfunction. The present invention also relates to the use of a proteasome inhibitor as a low-dose treatment.

Abstract: The present invention relates to the use of a ligand of CDw52 for the preparation of a medicament for the treatment of diseases that are related to CDw52 expressing degenerated macrophages. In particular, the present invention relates to the treatment of diseases such as MAS, LCH, HLH, and AML.