Abstract: In one aspect the present invention is concerned with a method of cell culture, comprising the steps of (i) obtaining a stem or progenitor cell sample, (ii) culturing the stem or progenitor cell sample in media and under closed conditions appropriate to cause proliferation or differentiation of the stem or progenitor cells, wherein the media comprises a vEPO protein variant, (iii) purifying the stem or progenitor cells ex vivo. The invention relates to a method of increasing the number and survival of stem and progenitor cells in vitro and in vivo using a vEPO protein variant. The invention also relates to improved differentiation of stem and progenitor cells in vitro and in vivo using a vEPO protein variant.

Abstract: The present invention relates to an IgY composition characterized in that said IgY composition contains IgY antibodies, fragments, and/or Fab fragments thereof that specifically bind to a peptide with the amino acid sequence of SEQ ID NO: 1 and to the use of this IgY composition in the therapy of celiac disease, rheumatism, and/or wheat allergy.

Abstract: The present invention refers to a method of infiltrating enamel for the prevention and/or treatment of carious lesions comprising (a) exposing an enamel area to a conditioner comprising hydrochloric acid; (b) exposing the conditioned enamel area to an infiltrant; and (c) curing the infiltrant. The present invention further refers to a kit for carrying out the method of infiltrating enamel, which comprises a conditioner comprising hydrochloric acid and an infiltrant comprising at least one low viscous dental resin. Alternatively, the kit comprises ready-to-use means for carrying out the method of infiltrating enamel, e.g. application strips with delivery pads soaked with conditioner or infiltrant. The present invention also refers to a method for identifying an infiltrant by calculation of the penetration coefficient, and to an infiltrant identified by the method having a penetration coefficient of >50 cm/s or comprising a low viscous light curing resin having a penetration coefficient of >50 cm/s.

Abstract: The invention relates to fluorinated fentanyl derivatives that function as opioid receptor agonists, which activate target opioid receptors in a pH-dependent manner, and are thus selective for the receptors in inflamed (acidic) milieu; uses thereof and pharmaceutical compositions comprising them.

Abstract: The invention relates to, inter alia, a method for characterizing tissue of human or animal tissue, wherein a vector field (u) is established, which specifies the mechanical deflection or a time derivative of the mechanical deflection of tissue particles present in the tissue, the divergence of the vector field (?·u) is determined and the divergence of the vector field is used as a measurement result characterizing the tissue for the purposes of tissue characterization.

Abstract: The present invention is directed to an aptamer comprising or consisting of the nucleic acid sequence of SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 and/or a nucleic acid sequence being at least 80% identical to one of SEQ ID No. 1, 2 and 3 for use in therapy and/or diagnosis of autoimmune diseases, wherein the autoimmune disease is cardiomyopathy, dilated cardiomyopathy (DCM), peripartum cardiomyopathy (PPCM), idiopathic cardiomyopathy, Chagas' cardiomyopathy, Chagas' megacolon, Chagas' megaesophagus, Chagas' neuropathy, benign prostatic hyperplasia, scleroderma, psoriasis, Raynaud syndrome, pre-eclamsia, kidney allograft rejection, myocarditis, glaucoma, hypertension, pulmonary hypertension, malignant hypertension, and/or Alzheimer's disease.

Abstract: The device for infiltration of approximal tooth surfaces, with a flexible planar element and with a holder into which the planar element is clamped, is characterized in that the planar element is a liquid-impermeable plastic film which has a surface area for taking up a liquid to be used for treatment, and in that the holder is a bow-shaped element with a web and two lateral arms which extend from the latter and are arranged in an arc-shape or U-shape, to which the plastic film is connected in a liquid-impermeable manner.

Abstract: The present invention refers to a peptidic or non-peptidic angiotensin(1-7) (Ang-(1-7)) receptor agonist, preferably a Mas receptor agonist, for the prevention and/or treatment of acute lung injury, preferably acute respiratory distress syndrome.

Abstract: The invention provides antibody against p40, IL-12 or IL-23 for the prevention or treatment of Alzheimer's disease. It further provides ligands to the pair of interleukin 12 or 23 and its specific receptor, specifically an antibody, an antibody fragment, an antibody-like-molecule, for the prevention or treatment of Alzheimer's disease. Similarly, siRNA, antisense or transcription factor modulators of gene expression of p19, p35, p40, IL-12R-?1, IL-12R-?2, and/or IL-23R for the prevention or treatment of Alzheimer's disease are provided.

Abstract: The present invention is directed to an isolated miR-206 target site, comprising or consisting of a nucleic acid sequence with a sequence identity of at least 80% compared to wild type miR-206 target site with SEQ ID No. 1, characterized in that the nucleic acid sequence comprises at least one nucleotide substitution at a position from nucleotide 2 to 8 and/or at least one nucleotide substitution at a position from nucleotide 12 to 16 of SEQ D No. 1, wherein the nucleotide positions of SEQ ID No. 1 are numbered from the 3?- to the 5?-end; as well as to an expression cassette, vector and pharmaceutical composition comprising at least one isolated miR-206 target site of the invention.

Abstract: The present invention relates to an X-ray system and method for generating 3D image data. The X-ray system comprises a radiation detector, a movable X-ray tube assembly and a control unit, wherein in a working state of the system the radiation detector is detachably positioned in a spatially fixed manner and the X-ray tube assembly can be moved into relative positions relative to the radiation detector. Projection images recorded in the relative positions can be processed together with the coordinates of the relative positions using an iterative reconstruction technique or other image processing methods so as to obtain 3D X-ray images. The X-ray tube assembly is attached to a motor-driven movable stand arm and can be displaced using a control unit. The stand base of the movable stand can be positioned in a spatially fixed manner, so that it has a defined fixed position relative to the radiation detector.

Abstract: Linear polypeptide epitopes of hazelnut cor a 1 and celery api 1.0101 allergen of a sequence length of ten to fifteen amino acids for treatment and prevention of hazelnut or celery allergy are provided. Means and methods for diagnosing hazelnut or celery allergy, and for detecting hazelnut or celery allergens in a sample, are also provided.

Abstract: The device for infiltration of approximal tooth surfaces, with a flexible planar element and with a holder into which the planar element is clamped, is characterized in that the planar element is a liquid-impermeable plastic film which has a surface area for taking up a liquid to be used for treatment, and in that the holder is a bow-shaped element with a web and two lateral arms which extend from the latter and are arranged in an arc-shape or U-shape, to which the plastic film is connected in a liquid-impermeable manner.

Abstract: The present invention is directed to the use of a cell line in the production of sialylated glycoprotein, wherein said cell line expresses functional ASGPR protein as well as to a method for the production of sialylated glycoproteins, characterized in that such a cell line is used.

Abstract: The application provides Ang-(1-7) receptor agonist peptides and their use for treating acute lung injury.

Abstract: The application provides Ang-(1-7) receptor agonist peptides and their use for treating acute lung injury.

Abstract: The invention relates to the use of substances which are specific to CEACAM8 for the manufacture of a medicament for the prophylactic or therapeutic treatment of human autoimmune diseases and/or gout. Another object of the invention concerns the use of CEACAM8-specific substances for apoptosis induction in-vitro. The invention also relates to a method for screening substances which induce apoptosis and a method for inducing apoptosis in human granulocytes.

Abstract: A device and method for producing mechanical oscillations in a research object using magnetic resonance elastography (MRE) with a membrane that can be set into periodic motion and a transmission element for the transmission of periodic motion of the membrane onto the research object, whereby the membrane is connected to the transmission element by means of a mounting medium in such a way that periodic motion of the membrane is transmitted over the mounting medium to the transmission element.

Abstract: The present invention relates to a method, preferably an ex vivo method, for diagnosing prostate carcinomas and/or predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from prostate carcinomas or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby prostate carcinomas or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium.

Abstract: The invention relates to a peptide and retro or retro-inverso peptide thereof, with a length of ?25 amino acid residues, characterized in that the peptide comprises at least one citrulline residue, and exhibits a sequence identity over the whole sequence of the peptide of ?70% compared to human hnRNP A3 protein (SEQ ID No. 1) and uses thereof.