Patents Assigned to Charles River Laboratories, Inc.
  • Publication number: 20240125789
    Abstract: The invention relates generally to hybrid amebocyte lysate compositions (including both native and recombinant components) and their use in detecting and/or quantifying endotoxin in a sample.
    Type: Application
    Filed: February 11, 2022
    Publication date: April 18, 2024
    Applicant: Charles River Laboratories, Inc.
    Inventors: Norman R. Wainwright, Masakazu Tsuchiya, John Dubczak, Foster T. Jordan
  • Patent number: 11685773
    Abstract: The present invention relates to a method for producing a population of 20 or more nucleic acids, each encoding at least one protein comprising at least one immunoglobulin variable domain having a rabbit-derived CDR3 amino acid sequence embedded in essentially human framework sequences, as well as to a population of nucleic acids and a population of proteins relates thereto and uses thereof.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: June 27, 2023
    Assignees: ABCHECK s.r.o., CHARLES RIVER LABORATORIES, INC.
    Inventors: Jacob E. Gunn Glanville, Vera Molkenthin, Remko Albert Griep, Ahmad Trad, Peter Milovnik, Volker Lang
  • Patent number: 11221335
    Abstract: The application provides heat-treated Limulus amebocyte lysates useful for detecting ?-glucans.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: January 11, 2022
    Assignee: Charles River Laboratories, Inc.
    Inventor: Masakazu Tsuchiya
  • Patent number: 11124581
    Abstract: The present invention relates to a method for producing a population of nucleic acids encoding at least one protein comprising at least one immunoglobulin variable domain having a non-human-derived CDR3 amino acid sequence embedded in essentially human framework sequences, as well as to a population of nucleic acids and a population of proteins relates thereto and uses thereof.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: September 21, 2021
    Assignee: CHARLES RIVER LABORATORIES, INC.
    Inventor: Jacob Glanville
  • Patent number: 10976258
    Abstract: The invention relates to a porous planar cell capture system for use in determining the presence and/or amount of cells, for example, viable cells, in a liquid sample, and to methods of using such a cell capture system. The cell capture system contains a fluid permeable, planar membrane adopted to retain cells thereon, a fluid permeable support member that supports the membrane, and an optional register associated with the membrane.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: April 13, 2021
    Assignees: Charles River Laboratories, Inc., ReaMetrix Inc.
    Inventors: Norman R. Wainwright, Bala S. Manian, Eric Stimpson, Brian J. Kolonia, Robert K. Kolonia
  • Patent number: 10473663
    Abstract: The application provides heat-treated Limulus amebocyte lysates useful for detecting ?-glucans.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: November 12, 2019
    Assignee: Charles River Laboratories, Inc.
    Inventor: Masakazu Tsuchiya
  • Patent number: 10473664
    Abstract: The application provides heat-treated Limulus amebocyte lysates useful for detecting ?-glucans.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: November 12, 2019
    Assignee: Charles River Laboratories, Inc.
    Inventor: Masakazu Tsuchiya
  • Patent number: 10465228
    Abstract: The invention relates to a filtration system for use in a method of determining the presence and/or amount of cells, for example, viable cells, in a liquid sample, and to methods of using and manufacturing such a filtration system. The filtration system includes a cup with an upper portion and a ring portion, where the ring portion is separably coupled to the upper portion.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: November 5, 2019
    Assignee: Charles River Laboratories, Inc.
    Inventors: Norman R. Wainwright, Dana M. Nutter, Eric Stimpson, Al Fuchs, Thomas Preidel
  • Patent number: 10324036
    Abstract: The invention relates to a porous planar cell capture system for use in determining the presence and/or amount of cells, for example, viable cells, in a liquid sample, and to methods of using such a cell capture system. The cell capture system contains a fluid permeable, planar membrane adopted to retain cells thereon, a fluid permeable support member that supports the membrane, and an optional register associated with the membrane.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: June 18, 2019
    Assignees: Charles River Laboratories, Inc., ReaMetrix Inc.
    Inventors: Norman R. Wainwright, Bala S. Manian, Eric Stimpson, Brian J. Kolonia, Robert K. Kolonia
  • Patent number: 10119969
    Abstract: The invention provides methods and compositions for the detection and/or quantification of a microbial contaminant, for example, a bacterial endotoxin or a glucan, in a sample. In particular, the invention provides a test cartridge useful in the practice of hemocyte lysate-based assays for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides methods of making and using such cartridges. In addition, the invention provides a rapid, sensitive, multi-step kinetic hemocyte lysate-based assay for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides a glucan-specific lysate that can be used in a variety of assay formats, including, for example, a test cartridge, optionally configured to perform a kinetic assay.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: November 6, 2018
    Assignee: Charles River Laboratories, Inc.
    Inventors: Norman R. Wainwright, Foster T. Jordan
  • Patent number: 9709500
    Abstract: The invention relates to a method for determining the presence and/or amount of viable cells in a liquid sample. The method includes (a) labeling with a fluorescent label viable cells remaining on a porous membrane after passing the liquid sample therethrough, (b) scanning a portion of the porous membrane by rotating the porous membrane relative to a detection system, and (c) determining the presence and/or quantity of viable cells captured by the membrane.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: July 18, 2017
    Assignees: Charles River Laboratories, Inc., ReaMetrix Inc.
    Inventors: Norman R. Wainwright, Bala S. Manian, Eric Stimpson, Brian J. Kolonia, Robert K. Kolonia
  • Patent number: 9624463
    Abstract: The invention relates to a filtration system for use in a method of determining the presence and/or amount of cells, for example, viable cells, in a liquid sample, and to methods of using and manufacturing such a filtration system. The filtration system includes a cup with an upper portion and a ring portion, where the ring portion is separably coupled to the upper portion.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: April 18, 2017
    Assignee: Charles River Laboratories, Inc.
    Inventors: Norman R. Wainwright, Dana M. Nutter, Eric Stimpson, Al Fuchs, Thomas Preidel
  • Patent number: D776295
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: January 10, 2017
    Assignee: Charles River Laboratories, Inc.
    Inventors: Norman R. Wainwright, Dana M. Nutter, Eric Stimpson, Al Fuchs, Thomas Preidel
  • Patent number: D782694
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: March 28, 2017
    Assignee: Charles River Laboratories, Inc.
    Inventors: Norman R. Wainwright, Dana M. Nutter, Eric Stimpson, Al Fuchs, Thomas Preidel
  • Patent number: D821604
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: June 26, 2018
    Assignee: Charles River Laboratories, Inc.
    Inventors: Jason Tremblay, Dana M. Nutter, Elizabeth Mills, Luca Nicoli, Eric Stimpson, Thomas Preidel, Michael Braun
  • Patent number: D821605
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: June 26, 2018
    Assignee: Charles River Laboratories, Inc.
    Inventors: Jason Tremblay, Dana M. Nutter, Elizabeth Mills, Luca Nicoli, Eric Stimpson, Thomas Preidel, Michael Braun
  • Patent number: D829338
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: September 25, 2018
    Assignee: Charles River Laboratories, Inc.
    Inventors: Jason Tremblay, Dana M. Nutter, Elizabeth Mills, Luca Nicoli, Eric Stimpson, Thomas Preidel, Michael Braun
  • Patent number: D829340
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: September 25, 2018
    Assignee: Charles River Laboratories, Inc.
    Inventors: Jason Tremblay, Dana M. Nutter, Elizabeth Mills, Luca Nicoli, Eric Stimpson, Thomas Preidel, Michael Braun
  • Patent number: D831223
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: October 16, 2018
    Assignee: Charles River Laboratories, Inc.
    Inventors: Jason Tremblay, Dana M. Nutter, Elizabeth Mills, Luca Nicoli, Eric Stimpson, Thomas Preidel, Michael Braun
  • Patent number: D859488
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: September 10, 2019
    Assignee: Charles River Laboratories, Inc.
    Inventors: Jason Tremblay, Dana M. Nutter, Elizabeth Mills, Luca Nicoli, Eric Stimpson, Thomas Preidel, Michael Braun