Abstract: This invention relates to methods and compositions comprising antibodies or fragments thereof comprising a targeting ligand and engineered cytotoxic cells comprising a targeting agent specific for the targeting ligand, for use in inducing cytotoxicity in a cancer cell, in delivering a cytotoxic cell to a cancer cell in a subject, and in treating cancer.
Type:
Grant
Filed:
September 23, 2022
Date of Patent:
January 23, 2024
Assignee:
The Charlotte Mecklenburg Hospital Authority
Abstract: In one aspect, devices for image guided laparoscopic surgery are disclosed. Such devices can comprise a shaft, a surgical component, a handle, and one or more sensors. The shaft comprises a proximal end and a terminal end that opposes the proximal end. The surgical component is disposed at the terminal end of the shaft, and the handle extends from the proximal end of the shaft. The handle comprises one or more actuating components configured to actuate the surgical component. The one or more sensors are disposed on or over the handle, and are configured to detect and/or track movement of the handle and/or actuation of one or more of the actuating components.
Type:
Grant
Filed:
December 21, 2017
Date of Patent:
July 5, 2022
Assignee:
THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY
Abstract: The present disclosure describes a surgical training model that emulates a human pelvis for robotic, laparoscopic, and/or abdominal/open approach surgical training. Methods of performing a simulated surgery using the surgical training model are also provided.
Type:
Grant
Filed:
February 13, 2019
Date of Patent:
June 28, 2022
Assignee:
The Charlotte Mecklenburg Hospital Authority
Inventors:
Erinn M. Myers, Megan E. Tarr, Brittany L. Anderson-Montoya, Heather Fasano, Smitha Vilasagar
Abstract: The present invention provides methods and compositions involving microbiome signatures and their association with oral complications of cancer therapy.
Type:
Grant
Filed:
June 23, 2017
Date of Patent:
March 23, 2021
Assignee:
The Charlotte-Mecklenburg Hospital Authority
Inventors:
Farah K. B. Mougeot, Jean-Luc C. Mougeot
Abstract: Vascular devices and methods for addressing pathologies in the hemiarch of the aorta are provided. The device includes a main body and a secondary body. The main body has ends that are designed to be connected to corresponding ends of the native blood vessel. The secondary body has a free end and a fixed end that is engaged with an inner surface of the main body. The vascular device is movable from a retracted configuration, in which the secondary body is at least partially contained within the main body and the free end is on a proximal side of the fixed end, to an extended configuration, in which the secondary body is extended distally from the main body and the free end is on a distal side of the fixed end to address defects in the aorta downstream of the hemiarch.
Type:
Grant
Filed:
July 21, 2015
Date of Patent:
September 29, 2020
Assignee:
The Charlotte-Mecklenburg Hospital Authority
Abstract: The present invention provides methods for determining immunomodulatory derivatives (IMiDs) resistance in a subject having a plasma cell disorder.
Type:
Grant
Filed:
November 22, 2017
Date of Patent:
June 30, 2020
Assignee:
The Charlotte-Mecklenburg Hospital Authority
Inventors:
Saad Z. Usmani, Qing Zhang, Manisha Bhutani
Abstract: The present invention provides methods for determining the level or status of minimal residue disease (MRD) in a multiple myeloma (MM) patient including analyzing peripheral natural killer (NK), NK-T and T cell distribution and/or activation, and quantifying inflammatory cytokines, chemokines and growth factors in a biological sample obtained from an MM patient to provide a peripheral immune profile; and obtaining a level or status of MRD in the MM patient from the peripheral immune profile, wherein if the peripheral immune profile exceeds a pre-determined threshold, the MM patient is positive for MRD.
Type:
Grant
Filed:
December 1, 2017
Date of Patent:
May 19, 2020
Assignee:
The Charlotte Mecklenburg Hospital Authority
Inventors:
Saad Z. Usmani, Manisha Bhutani, Qing Zhang, David M. Foureau
Abstract: The present invention provides methods and compositions involving genetic markers and their association with oral mucositis occurring in patients who are treated with cancer therapy and/or conditioning therapy for hematopoietic stem cell transplantation.
Type:
Grant
Filed:
February 26, 2019
Date of Patent:
September 3, 2019
Assignee:
The Charlotte-Mecklenburg Hospital Authority
Inventors:
Jean-Luc C. Mougeot, Farah K. B. Mougeot
Abstract: The invention relates to synthetic polynucleotides encoding fukutin related protein (FKRP). The invention further relates to nucleic acid constructs comprising the synthetic polynucleotides and methods of using these synthetic polynucleotides to treat dystroglycanopathy disorders.
Type:
Grant
Filed:
August 25, 2017
Date of Patent:
July 16, 2019
Assignees:
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, THE CHARLOTTE MECKLENBURG HOSPITAL AUTHORITY
Abstract: A system for supporting ribs is provided that includes first and second reinforcing members, fasteners, and closure members. Each reinforcing member may be attached to a respective rib via fasteners such that the reinforcing member spans one or more fractures of the ribs. In addition to individually holding the portions of the rib bone together to allow the fracture to heal, however, the reinforcing members may be used on rib pairs such that closure members may be wrapped around or extended between the rib pair in an effort to stabilize the ribs. By providing extended regions configured to receive closure members, healing of the ribs may be promoted and facilitated without creating unnecessary other pain to the patient, as the rounded portions serve to keep the closure members away from the neurovascular bundles associated with the ribs.
Type:
Grant
Filed:
July 2, 2014
Date of Patent:
March 5, 2019
Assignee:
The Charlotte Mecklenburg Hospital Authority
Abstract: A surgical drape (100) is described that is aimed at providing a way to direct a maximum amount of fluid (e.g., distention fluid) discharged from the patient's uterine cavity to a collection point, such as a fluid management system, during a hysteroscopic procedure. The surgical drape may include a cover portion (105) and a collection portion (110) that is attached to the cover portion (105). The cover portion (105) may define an opening (115) that provides a surgeon with surgical access to the patient for performing a medical procedure. The collection portion (110) may include a main panel (120) that can be attached to the patient's back distally of the gluteal cleft (e.g., via an adhesive strip). The main panel (110) may include a pocket (170), via which the surgeon may insert his hands to position the main panel (110) under the patient without disturbing the sterile field.
Type:
Grant
Filed:
May 30, 2014
Date of Patent:
January 22, 2019
Assignee:
The Charlotte-Mecklenburg Hospital Authority