Patents Assigned to Charlotte-Mecklenburg Hospital Authority
  • Patent number: 10456367
    Abstract: The present invention provides compositions and methods of their use in treating muscular dystrophy and other disorders.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: October 29, 2019
    Assignee: The Charlotte Mecklenburg Hospital Authority
    Inventor: Qi Long Lu
  • Patent number: 10434113
    Abstract: The present invention provides compositions and methods of their use in treating muscular dystrophy and other disorders.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: October 8, 2019
    Assignee: The Charlotte Mecklenburg Hospital Authority
    Inventors: Qi Long Lu, Marcela Cataldi, Pei Juan Lu
  • Patent number: 10400271
    Abstract: The present invention provides methods and compositions involving genetic markers and their association with oral mucositis occurring in patients who are treated with cancer therapy and/or conditioning therapy for hematopoietic stem cell transplantation.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: September 3, 2019
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventors: Jean-Luc C. Mougeot, Farah K. B. Mougeot
  • Patent number: 10350305
    Abstract: The invention relates to synthetic polynucleotides encoding fukutin related protein (FKRP). The invention further relates to nucleic acid constructs comprising the synthetic polynucleotides and methods of using these synthetic polynucleotides to treat dystroglycanopathy disorders.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: July 16, 2019
    Assignees: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, THE CHARLOTTE MECKLENBURG HOSPITAL AUTHORITY
    Inventors: Qi Long Lu, Xiao Xiao
  • Patent number: 10245235
    Abstract: The present invention provides compositions and methods of their use in treating muscular dystrophy and other disorders.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: April 2, 2019
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventor: Qi Long Lu
  • Patent number: 10222376
    Abstract: The present invention provides methods and compositions for identifying leukemic stem cells.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: March 5, 2019
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventor: Jonathan M. Gerber
  • Patent number: 10219849
    Abstract: A system for supporting ribs is provided that includes first and second reinforcing members, fasteners, and closure members. Each reinforcing member may be attached to a respective rib via fasteners such that the reinforcing member spans one or more fractures of the ribs. In addition to individually holding the portions of the rib bone together to allow the fracture to heal, however, the reinforcing members may be used on rib pairs such that closure members may be wrapped around or extended between the rib pair in an effort to stabilize the ribs. By providing extended regions configured to receive closure members, healing of the ribs may be promoted and facilitated without creating unnecessary other pain to the patient, as the rounded portions serve to keep the closure members away from the neurovascular bundles associated with the ribs.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: March 5, 2019
    Assignee: The Charlotte Mecklenburg Hospital Authority
    Inventor: Jeko Metodiev Madjarov
  • Patent number: 10182877
    Abstract: A surgical drape (100) is described that is aimed at providing a way to direct a maximum amount of fluid (e.g., distention fluid) discharged from the patient's uterine cavity to a collection point, such as a fluid management system, during a hysteroscopic procedure. The surgical drape may include a cover portion (105) and a collection portion (110) that is attached to the cover portion (105). The cover portion (105) may define an opening (115) that provides a surgeon with surgical access to the patient for performing a medical procedure. The collection portion (110) may include a main panel (120) that can be attached to the patient's back distally of the gluteal cleft (e.g., via an adhesive strip). The main panel (110) may include a pocket (170), via which the surgeon may insert his hands to position the main panel (110) under the patient without disturbing the sterile field.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: January 22, 2019
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventor: Paul B. Marshburn
  • Patent number: 10127837
    Abstract: A training device for the preparation, execution and maintenance of central venous catheters comprising a central block including a cavern traversing through the block, a tube running through the cavern, a reservoir containing a liquid with a distal end of the tube engaged with the reservoir, a covering material secured over the central block, a guidewire extended through the covering material and within the tube, a hydraulic or pneumatic device operationally associated with the reservoir and allowing the reservoir and the tube to be filled and pressurized with the liquid, a scalpel or similar instrument for making a small incision in the covering material at the site where the guide wire extends through the covering material, a dilator to expand the incision opening and then remove from the incision and guidewire and a catheter to feed over the guidewire and into the incision.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: November 13, 2018
    Assignee: Charlotte-Mecklenburg Hospital Authority
    Inventors: Laura L. Cragg, Dawn Marie Swiderski, Scott Wilson, Kenneth C. Paulus, Christopher Hutchison
  • Patent number: 10072296
    Abstract: The present invention provides methods and compositions involving epigenetic and gene expression signatures and their association with Sjögren's syndrome.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: September 11, 2018
    Assignee: The Charlotte Mecklenburg Hospital Authority
    Inventors: Jean-Luc C. Mougeot, Farah K. B. Mougeot, Nirav Shah
  • Patent number: 9993339
    Abstract: Devices and methods are described for treating a mitral valve defect. The device described includes features that allow the device to conform to the actual pathology of the valve, rather than attempting to replicate a healthy valve (which the patient does not have). In this way, the device allows the patient's actual value to work as well as possible, given the valve's diseased condition. The actual pathology of the valve is accommodated by providing for multiple dimensions of adjustability of the device, including adjustability of the size (e.g., diameter) of the device as well as adjustability of the elevation or inclination of one portion of the device (e.g., the portion supporting the posterior leaflet) with respect to another portion of the device.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 12, 2018
    Assignee: THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY
    Inventors: Jeko Metodiev Madjarov, Sevtozar Madzharov, Charles Bridges, Liam Ryan
  • Patent number: 9907590
    Abstract: Systems, devices, and methods for longitudinal closure of a dissected sternum are provided. The system includes first and second reinforcing members, fasteners, and closure members. Each reinforcing member is configured to be placed on an outer surface of a respective sternum portion, such that each reinforcing member is longitudinally disposed on an opposite side of a sternum opening with respect to the other reinforcing member. Fasteners may be placed in holes defined in the reinforcing members to secure a respective reinforcing member to a corresponding sternum portion. The closure members, which may be sternal closing wires, may then be wrapped around the sternum portions and the reinforcing members transversely to close the sternum opening. Because the reinforcing members include extended regions having lateral edges that extend away from a midline of the respective reinforcing member, the closure members are moved away from the edges of the bone.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: March 6, 2018
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventor: Jeko Metodiev Madjarov
  • Patent number: 9907616
    Abstract: A system for use in TFL lithotripsy procedures uses a silica trunk fiber semi-permanently mounted in an endoscope and includes a detachable and replaceable wave guide treatment tip, including hollow wave guides and fiber tips. The system provides for ready removal and replacement of wave guides damaged during lithotripsy. The trunk fiber in the endoscope tube is of diameter ?200 ?m, suitable for use in the lower pole of the kidney, and should be useful over-and-over with only the detachable wave guide removed and replaced, whether during a single procedure or for multiple procedures on different patients in which the endoscope tube and trunk fiber are sterilized between patients. Multiple connector assemblies are provided for optical coupling contact between the detachable wave guide and trunk fiber and include a gap for dissipation of heat between the trunk fiber and the wave guide when in optically coupling contact.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: March 6, 2018
    Assignees: University of North Carolina at Charlotte, The Charlotte Mecklenburg Hospital Authority
    Inventors: Nathaniel Michael Fried, Richard Leious Blackmon, Pierce Butler Irby, III, Thomas Clifton Hutchens
  • Patent number: 9883908
    Abstract: Medical devices are described for performing mapping, ablating, and/or pacing procedures on one or more layers of the cardiac wall via an epicardial approach in a minimally invasive (e.g., orthoscopic) surgical procedure. One of the medical devices described includes a main support member and one or more secondary support members extending outwardly from the main support member having electrodes configured to receive electrical impulses. The secondary support member may include a support pad configured to be removably attached to a corresponding area of the epicardium for holding the medical device in place during a procedure, such as through application of vacuum pressure via a containment dome provided on each secondary support member. Further, an ablating electrode may be slidably disposed along the main support member for transmitting energy to a target site proximate the electrode. Associated methods are also described.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: February 6, 2018
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventors: Jeko Metodiev Madjarov, John Michael Fedor, Jackie H. Kasell
  • Patent number: 9872851
    Abstract: The present invention provides methods for treating or preventing portal hypertension comprising administering to a patient in need of such treatment or prevention at least one Rev-erb modulating agent (REMA) in an amount effective to treat or prevent said portal hypertension. The REMA can be SR6452 or a related compound, such as SR9009 or SR9011. The amount of the REMA administered can comprises a quantity sufficient to modulate Rev-erb? expression, activity, and/or subcellular location and/or to inhibit or reverse hepatic stellate cell (HSC) activation and contractility.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: January 23, 2018
    Assignee: THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY
    Inventors: Ting Li, Laura Schrum, Jonel Trebicka
  • Patent number: 9775675
    Abstract: A passively flexible ureteroscope having a diameter of less than about 2.5 millimeters is provided. The ureteroscope may help overcome many of the problems associated with the prior art devices and methods for removing kidney stones. The ureteroscope includes an elongate member having a distal portion, a proximal portion, and an inner conduit that extends longitudinally between the proximal and distal portions. The elongate member is made from a passively flexible material that is capable of being inserted and directed through a patient's body cavity, such as the ureter, by manual direction and pressure so that minimal, if any, additional mechanical or steering mechanisms are present. An imaging device and light source are provided at the distal portion of the elongate member to allow for positioning the device with respect to the stone. A laser fiber can be directed through the conduit to destroy a targeted stone.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: October 3, 2017
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventor: Pierce B. Irby, III
  • Patent number: 9750718
    Abstract: The present invention is directed to compositions and associated methods for treatment, prevention, amelioration, and/or delaying the onset of hepatic fibrosis and/or associated diseases. The methods preferably involve regulating at least one of Rev-erb? expression, activity, and subcellular localization. In particular, certain embodiments of the present invention relate to compositions and methods of using a Rev-erb-modulating agent (REMA) for the treatment or prevention of hepatic fibrosis and/or associated diseases. Preferably, the amount of a REMA administered comprises a quantity sufficient to modulate at least one of Rev-erb? expression, activity, and subcellular localization and reduce the activation of hepatic stellate cells (HSCs).
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: September 5, 2017
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventors: Ting Li, Laura Schrum
  • Patent number: 9713623
    Abstract: The present invention provides compounds of Formula I or Formula II: wherein: T, V, W, Y and Z are each independently selected from the group of substituents described herein, and X is a linker as further described herein. The present invention further provides compositions and conjugates including the compounds as well as methods of using these compounds including, but not limited to, methods of preventing, treating and/or diagnosing genetic disorders, such as muscular dystrophy, or non-genetic disorders as described herein.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: July 25, 2017
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventors: Mingxing Wang, Qi Lu
  • Patent number: 9664693
    Abstract: Methods and kits for characterizing liver damage in an individual are provided. The methods employ the use of immune analytes as biomarkers for detecting liver damage and predicting the likelihood that an individual suffering from liver damage will experience life-threatening liver failure. Concentration values for serum albumin and other identified immune analytes are obtained or determined from a blood sample taken from the individual. The obtained concentration values are then compared to corresponding concentrations from individuals having a healthy liver. By comparing the concentrations, an individual's likelihood of developing life-threatening liver failure and needing a liver transplant within a given time period (e.g., 6 months) can be identified.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: May 30, 2017
    Assignee: THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY
    Inventors: Herbert L. Bonkovsky, David Foureau, H. James Norton, Nury Steuerwald
  • Patent number: 9655678
    Abstract: Methods for treating urinary (kidney) stones in patients using a small outer diameter ureteroscope may help overcome problems associated with conventional methods for removing kidney stones and may minimize patient discomfort, avoid hospitalization and reduce costs associated with more conventional surgical treatments of kidney stones. The methods can be carried out in an outpatient environment such as a urologists' office without requiring general anesthesia.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: May 23, 2017
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventor: Pierce B. Irby, III