Patents Assigned to Charlotte-Mecklenburg Hospital Authority
  • Patent number: 10993954
    Abstract: The present invention provides compositions and methods of their use in treating muscular dystrophy and other disorders.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: May 4, 2021
    Assignee: The Charlotte Mecklenburg Hospital Authority
    Inventors: Qi Long Lu, Marcela Cataldi, Pei Juan Lu
  • Patent number: 10954571
    Abstract: The present invention provides methods and compositions involving microbiome signatures and their association with oral complications of cancer therapy.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: March 23, 2021
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventors: Farah K. B. Mougeot, Jean-Luc C. Mougeot
  • Patent number: 10786345
    Abstract: Vascular devices and methods for addressing pathologies in the hemiarch of the aorta are provided. The device includes a main body and a secondary body. The main body has ends that are designed to be connected to corresponding ends of the native blood vessel. The secondary body has a free end and a fixed end that is engaged with an inner surface of the main body. The vascular device is movable from a retracted configuration, in which the secondary body is at least partially contained within the main body and the free end is on a proximal side of the fixed end, to an extended configuration, in which the secondary body is extended distally from the main body and the free end is on a distal side of the fixed end to address defects in the aorta downstream of the hemiarch.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: September 29, 2020
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventor: Jeko Metodiev Madjarov
  • Patent number: 10751298
    Abstract: The present invention provides compositions and methods of their use in treating muscular dystrophy and other disorders.
    Type: Grant
    Filed: February 17, 2020
    Date of Patent: August 25, 2020
    Assignee: The Charlotte Mecklenburg Hospital Authority
    Inventor: Qi Long Lu
  • Patent number: 10697024
    Abstract: The present invention provides methods for determining immunomodulatory derivatives (IMiDs) resistance in a subject having a plasma cell disorder.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: June 30, 2020
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventors: Saad Z. Usmani, Qing Zhang, Manisha Bhutani
  • Patent number: 10656144
    Abstract: The present invention provides methods for determining the level or status of minimal residue disease (MRD) in a multiple myeloma (MM) patient including analyzing peripheral natural killer (NK), NK-T and T cell distribution and/or activation, and quantifying inflammatory cytokines, chemokines and growth factors in a biological sample obtained from an MM patient to provide a peripheral immune profile; and obtaining a level or status of MRD in the MM patient from the peripheral immune profile, wherein if the peripheral immune profile exceeds a pre-determined threshold, the MM patient is positive for MRD.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: May 19, 2020
    Assignee: The Charlotte Mecklenburg Hospital Authority
    Inventors: Saad Z. Usmani, Manisha Bhutani, Qing Zhang, David M. Foureau
  • Patent number: 10561623
    Abstract: The present invention provides compositions and methods of their use in treating muscular dystrophy and other disorders.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: February 18, 2020
    Assignee: The Charlotte Mecklenburg Hospital Authority
    Inventor: Qi Long Lu
  • Patent number: 10456367
    Abstract: The present invention provides compositions and methods of their use in treating muscular dystrophy and other disorders.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: October 29, 2019
    Assignee: The Charlotte Mecklenburg Hospital Authority
    Inventor: Qi Long Lu
  • Patent number: 10434113
    Abstract: The present invention provides compositions and methods of their use in treating muscular dystrophy and other disorders.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: October 8, 2019
    Assignee: The Charlotte Mecklenburg Hospital Authority
    Inventors: Qi Long Lu, Marcela Cataldi, Pei Juan Lu
  • Patent number: 10400271
    Abstract: The present invention provides methods and compositions involving genetic markers and their association with oral mucositis occurring in patients who are treated with cancer therapy and/or conditioning therapy for hematopoietic stem cell transplantation.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: September 3, 2019
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventors: Jean-Luc C. Mougeot, Farah K. B. Mougeot
  • Patent number: 10350305
    Abstract: The invention relates to synthetic polynucleotides encoding fukutin related protein (FKRP). The invention further relates to nucleic acid constructs comprising the synthetic polynucleotides and methods of using these synthetic polynucleotides to treat dystroglycanopathy disorders.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: July 16, 2019
    Assignees: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, THE CHARLOTTE MECKLENBURG HOSPITAL AUTHORITY
    Inventors: Qi Long Lu, Xiao Xiao
  • Patent number: 10245235
    Abstract: The present invention provides compositions and methods of their use in treating muscular dystrophy and other disorders.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: April 2, 2019
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventor: Qi Long Lu
  • Patent number: 10222376
    Abstract: The present invention provides methods and compositions for identifying leukemic stem cells.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: March 5, 2019
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventor: Jonathan M. Gerber
  • Patent number: 10219849
    Abstract: A system for supporting ribs is provided that includes first and second reinforcing members, fasteners, and closure members. Each reinforcing member may be attached to a respective rib via fasteners such that the reinforcing member spans one or more fractures of the ribs. In addition to individually holding the portions of the rib bone together to allow the fracture to heal, however, the reinforcing members may be used on rib pairs such that closure members may be wrapped around or extended between the rib pair in an effort to stabilize the ribs. By providing extended regions configured to receive closure members, healing of the ribs may be promoted and facilitated without creating unnecessary other pain to the patient, as the rounded portions serve to keep the closure members away from the neurovascular bundles associated with the ribs.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: March 5, 2019
    Assignee: The Charlotte Mecklenburg Hospital Authority
    Inventor: Jeko Metodiev Madjarov
  • Patent number: 10182877
    Abstract: A surgical drape (100) is described that is aimed at providing a way to direct a maximum amount of fluid (e.g., distention fluid) discharged from the patient's uterine cavity to a collection point, such as a fluid management system, during a hysteroscopic procedure. The surgical drape may include a cover portion (105) and a collection portion (110) that is attached to the cover portion (105). The cover portion (105) may define an opening (115) that provides a surgeon with surgical access to the patient for performing a medical procedure. The collection portion (110) may include a main panel (120) that can be attached to the patient's back distally of the gluteal cleft (e.g., via an adhesive strip). The main panel (110) may include a pocket (170), via which the surgeon may insert his hands to position the main panel (110) under the patient without disturbing the sterile field.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: January 22, 2019
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventor: Paul B. Marshburn
  • Patent number: 10127837
    Abstract: A training device for the preparation, execution and maintenance of central venous catheters comprising a central block including a cavern traversing through the block, a tube running through the cavern, a reservoir containing a liquid with a distal end of the tube engaged with the reservoir, a covering material secured over the central block, a guidewire extended through the covering material and within the tube, a hydraulic or pneumatic device operationally associated with the reservoir and allowing the reservoir and the tube to be filled and pressurized with the liquid, a scalpel or similar instrument for making a small incision in the covering material at the site where the guide wire extends through the covering material, a dilator to expand the incision opening and then remove from the incision and guidewire and a catheter to feed over the guidewire and into the incision.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: November 13, 2018
    Assignee: Charlotte-Mecklenburg Hospital Authority
    Inventors: Laura L. Cragg, Dawn Marie Swiderski, Scott Wilson, Kenneth C. Paulus, Christopher Hutchison
  • Patent number: 10072296
    Abstract: The present invention provides methods and compositions involving epigenetic and gene expression signatures and their association with Sjögren's syndrome.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: September 11, 2018
    Assignee: The Charlotte Mecklenburg Hospital Authority
    Inventors: Jean-Luc C. Mougeot, Farah K. B. Mougeot, Nirav Shah
  • Patent number: 9993339
    Abstract: Devices and methods are described for treating a mitral valve defect. The device described includes features that allow the device to conform to the actual pathology of the valve, rather than attempting to replicate a healthy valve (which the patient does not have). In this way, the device allows the patient's actual value to work as well as possible, given the valve's diseased condition. The actual pathology of the valve is accommodated by providing for multiple dimensions of adjustability of the device, including adjustability of the size (e.g., diameter) of the device as well as adjustability of the elevation or inclination of one portion of the device (e.g., the portion supporting the posterior leaflet) with respect to another portion of the device.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 12, 2018
    Assignee: THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY
    Inventors: Jeko Metodiev Madjarov, Sevtozar Madzharov, Charles Bridges, Liam Ryan
  • Patent number: 9907590
    Abstract: Systems, devices, and methods for longitudinal closure of a dissected sternum are provided. The system includes first and second reinforcing members, fasteners, and closure members. Each reinforcing member is configured to be placed on an outer surface of a respective sternum portion, such that each reinforcing member is longitudinally disposed on an opposite side of a sternum opening with respect to the other reinforcing member. Fasteners may be placed in holes defined in the reinforcing members to secure a respective reinforcing member to a corresponding sternum portion. The closure members, which may be sternal closing wires, may then be wrapped around the sternum portions and the reinforcing members transversely to close the sternum opening. Because the reinforcing members include extended regions having lateral edges that extend away from a midline of the respective reinforcing member, the closure members are moved away from the edges of the bone.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: March 6, 2018
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventor: Jeko Metodiev Madjarov
  • Patent number: 9907616
    Abstract: A system for use in TFL lithotripsy procedures uses a silica trunk fiber semi-permanently mounted in an endoscope and includes a detachable and replaceable wave guide treatment tip, including hollow wave guides and fiber tips. The system provides for ready removal and replacement of wave guides damaged during lithotripsy. The trunk fiber in the endoscope tube is of diameter ?200 ?m, suitable for use in the lower pole of the kidney, and should be useful over-and-over with only the detachable wave guide removed and replaced, whether during a single procedure or for multiple procedures on different patients in which the endoscope tube and trunk fiber are sterilized between patients. Multiple connector assemblies are provided for optical coupling contact between the detachable wave guide and trunk fiber and include a gap for dissipation of heat between the trunk fiber and the wave guide when in optically coupling contact.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: March 6, 2018
    Assignees: University of North Carolina at Charlotte, The Charlotte Mecklenburg Hospital Authority
    Inventors: Nathaniel Michael Fried, Richard Leious Blackmon, Pierce Butler Irby, III, Thomas Clifton Hutchens