Patents Assigned to Chatham Biotec, Limited
  • Process to prepare camptothecin derivatives
    Patent number: 8592588
    Abstract: A process is provided for the preparation of camptothecin derivatives, such as irinotecan, in a one-pot operation.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: November 26, 2013
    Assignee: Chatham Biotec, Limited
    Inventor: Ragina Naidu
  • One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
    Patent number: 8293930
    Abstract: A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: October 23, 2012
    Assignee: Chatham Biotec, Limited
    Inventor: Ragina Naidu
  • Semi-synthetic conversion of paclitaxel to docetaxel
    Patent number: 7906661
    Abstract: A process is provided for the semi-synthesis of taxane derivatives useful in the preparation of docetaxel, in particular, the semi-synthesis of protected taxane derivatives in a one pot reaction of protecting the C-2?, C-7 and C-10 positions and introducing a t-Boc group at the nitrogen of the amide group at the C-3? position in paclitaxel and subsequently conversion to docetaxel, and derivatives used therein.
    Type: Grant
    Filed: June 29, 2005
    Date of Patent: March 15, 2011
    Assignee: Chatham Biotec, Limited
    Inventors: Ragina Naidu, Samuel Siang Kiang Foo, BaoYu Xue, Bo Fan
  • Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
    Patent number: 7893283
    Abstract: A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: February 22, 2011
    Assignee: Chatham Biotec, Limited
    Inventor: Ragina Naidu
  • Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes
    Patent number: 7838694
    Abstract: A process is provided for the semi-synthesis and isolation of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis and isolation of 10-deacetylbaccatin III, the semi-synthesis of a mixture of 10-deacetylbaccatin III and baccatin III, and protected derivatives thereof, from a mixture of taxanes.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: November 23, 2010
    Assignee: Chatham Biotec, Limited
    Inventors: Ragina Naidu, Samuel Siang Kiang Foo
  • Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel
    Patent number: 7585986
    Abstract: A process is provided for the semi-synthesis of taxane intermediates and aziridine analogues of cephalomannine and baccatin III intermediates, and the conversion of such intermediates and analogues to paclitaxel and docetaxel.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: September 8, 2009
    Assignee: Chatham Biotec, Limited
    Inventor: Ragina Naidu
  • Semi-Synthesis and Isolation of Taxane Intermediates from a Mixture of Taxanes
    Publication number: 20080146824
    Abstract: A process is provided for the semi-synthesis and isolation of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis and isolation of 10-deacetylbaccatin III, the semi-synthesis of a mixture of 10-deacetylbaccatin III and baccatin III, and protected derivatives thereof, from a mixture of taxanes.
    Type: Application
    Filed: April 22, 2005
    Publication date: June 19, 2008
    Applicant: Chatham Biotec, Limited
    Inventors: Ragina Naidu, Samuel Siang Kiang Foo