Patents Assigned to Chem-Master International, Inc.
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Publication number: 20230265041Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NFK-B activation in a population of cells.Type: ApplicationFiled: February 27, 2023Publication date: August 24, 2023Applicants: The Research Foundation for the State University of New York, Chem-Master International, Inc.Inventors: Francis Johnson, Lorne Johnson
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Patent number: 11608309Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.Type: GrantFiled: May 28, 2020Date of Patent: March 21, 2023Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL INC.Inventors: Francis Johnson, Lorne Golub
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Publication number: 20210322346Abstract: A method of increasing production of one or more lipoxins in a subject in need thereof comprising administering to the subject an amount of a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, so as to thereby increase production of the one or more lipoxins in the subject.Type: ApplicationFiled: June 21, 2021Publication date: October 21, 2021Applicants: The Research Foundation for The State University of New York, Chem-Master International Inc.Inventors: Ying Gu, Hsi-ming Lee, Lorne M. Golub, Francis Johnson, Guirong Wang, Osama Abdel-Razek, Yongan Xu
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Publication number: 20210053905Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.Type: ApplicationFiled: May 28, 2020Publication date: February 25, 2021Applicants: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL, INC.Inventors: Francis Johnson, Lorne Golub
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Publication number: 20180036262Abstract: A method of increasing production of one or more lipoxins in a subject in need thereof comprising administering to the subject an amount of a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, so as to thereby increase production of the one or more lipoxins in the subject.Type: ApplicationFiled: March 10, 2016Publication date: February 8, 2018Applicants: The Research Foundation for the State University of New York, Chem-Master International Inc.Inventors: Ying Gu, Hsi-ming Lee, Lorne M. Golub, Francis Johnson, Guirong Wang, Osama Abdel-Razek, Yongan Xu
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Patent number: 9675576Abstract: The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 24, 2015Date of Patent: June 13, 2017Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL, INC.Inventors: Lorne M. Golub, Francis Johnson, Galina I. Botchkina, Iwao Ojima
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Publication number: 20170158605Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.Type: ApplicationFiled: December 19, 2016Publication date: June 8, 2017Applicants: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL, INC.Inventors: Francis Johnson, Lorne Golub
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Patent number: 9556105Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.Type: GrantFiled: October 14, 2015Date of Patent: January 31, 2017Assignees: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL, INC.Inventors: Francis Johnson, Lorne Golub
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Publication number: 20160355465Abstract: This invention provides a compound having the structure wherein ?, ?, A, B, and R1-R4 are defined herein. This invention also provides pharmaceutical compositions comprising the above compounds, a method of accelerating the healing of a wound, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.Type: ApplicationFiled: August 18, 2016Publication date: December 8, 2016Applicants: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL, INC.Inventors: Lorne M. GOLUB, Hsi-ming LEE, Francis JOHNSON
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Publication number: 20160213638Abstract: The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: November 24, 2015Publication date: July 28, 2016Applicants: The Research Foundation for The State University of New York, Chem-Master International, Inc.Inventors: Lorne M. GOLUB, Francis JOHNSON, Galina I. BOTCHKINA, Iwao OJIMA
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Publication number: 20160031795Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.Type: ApplicationFiled: October 14, 2015Publication date: February 4, 2016Applicants: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL, INC.Inventors: FRANCIS JOHNSON, LORNE GOLUB
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Patent number: 9187406Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.Type: GrantFiled: May 14, 2010Date of Patent: November 17, 2015Assignees: The Research Foundation of State University of New York, Chem-Master International, Inc.Inventors: Francis Johnson, Lorne Golub
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Publication number: 20150150834Abstract: The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 28, 2013Publication date: June 4, 2015Applicants: CHEM-MASTER INTERNATIONAL, INC., The Research Foundation for the State University of New YorkInventors: Lorne M. Golub, Francis Johnson, Galina I. Botchkina, Iwao Ojima
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Publication number: 20150073021Abstract: The present invention provides a method of inhibiting the binding of anthrax lethal factor with protective antigen comprising contacting the anthrax lethal factor with a compound having the structure:Type: ApplicationFiled: September 5, 2014Publication date: March 12, 2015Applicants: The Research Foundation for The State University of New York, Chem-Master International, Inc.Inventors: Anthony ANTONELLI, Sanford R. SIMON, Yu ZHANG, Lorne M. GOLUB, Francis JOHNSON
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Publication number: 20140275271Abstract: This invention provides a compound having the structure wherein ?, ?, A, B, and R1-R4 are defined herein. This invention also provides pharmaceutical compositions comprising the above compounds, a method of accelerating the healing of a wound, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.Type: ApplicationFiled: October 16, 2012Publication date: September 18, 2014Applicants: The Research Foundation for the State University of New York, Chem-Master International, Inc.Inventors: Lorne M. Golub, Hsi-ming Lee, Francis Johnson