Patents Assigned to Chemagis Ltd.
  • (1R, 1?R)-atracurium salts separation process
    Patent number: 8461338
    Abstract: The present invention provides an improved method of chromatographically separating the isomers of (1R,rR)-atracurium salts by high-performance liquid chromatography (HPLC), in the absence of a strong acid. The separation is preferably performed on a silica gel HPLC column using an eluent containing an organic solvent, a polar aprotic co-solvent and a weak organic acid.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: June 11, 2013
    Assignee: Chemagis Ltd.
    Inventors: Oded Arad, Elena Ostrovsky
  • CRYSTALLINE ROTIGOTINE BASE AND PREPARATION PROCESS THEREFOR
    Publication number: 20130096321
    Abstract: An isolated and pure crystalline rotigotine base of polymorph Form I, and processes for producing the crystalline rotigotine base are disclosed. Also disclosed is a transdermal patch for the delivery of rotigotine base using the disclosed isolated and pure form of rotigotine base, which can be used in treatment of Parkinson's Disease and other disorders ameliorated or treated by rotigotine, including restless leg syndrome.
    Type: Application
    Filed: December 3, 2012
    Publication date: April 18, 2013
    Applicant: CHEMAGIS LTD.
    Inventor: CHEMAGIS Ltd.
  • NOVEL PALONOSETRON SALTS AND PROCESSES FOR PREPARATION AND PURIFICATION THEREOF
    Publication number: 20130079521
    Abstract: Provided are novel salts of 2-(1-azabicyclo-[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one, methods of using such salts, and processes for producing such salts.
    Type: Application
    Filed: November 14, 2012
    Publication date: March 28, 2013
    Applicant: CHEMAGIS LTD.
    Inventor: CHEMAGIS LTD.
  • PROCESS FOR PRODUCING CISATRACURIUM AND ASSOCIATED INTERMEDIATES
    Publication number: 20130041154
    Abstract: The present invention provides a process of producing cisatracurium compounds, e.g., cisatracurium besylate, from isoquinolinium salts of the structural formula (VIIA) wherein X? is an anion and R is H or a C1-C6 alkyl, or an activated form of the carboxylic acid with 1,5-pentanediol to form a cisatracurium salt, optionally via an intermediate compound (VIII). The cisatracurium compounds can be purified using simple techniques to afford pure cisatracurium besylate without the need for HPLC purification.
    Type: Application
    Filed: October 10, 2012
    Publication date: February 14, 2013
    Applicant: CHEMAGIS LTD.
    Inventor: CHEMAGIS LTD.
  • Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
    Patent number: 8357807
    Abstract: The present invention provides novel isoquinolinium compounds, methods of producing the isoquinolinium compounds, and methods for converting them into cisatracurium, e.g., cisatracurium besylate. The isoquinolinium compounds of the present invention can be obtained in the form of solids, which can be purified using simple techniques and can be used to afford pure cisatracurium besylate without HPLC purification.
    Type: Grant
    Filed: May 1, 2008
    Date of Patent: January 22, 2013
    Assignee: CHEMAGIS Ltd.
    Inventors: Vladimir Naddaka, Shen Jingshan, Oded Arad, Guo Hongli, Ofer Sharon, Eyal Klopfer, Shady Saeed
  • (1R,1?R)-atracurium salts separation process
    Patent number: 8357805
    Abstract: The present invention provides an improved method for obtaining cisatracurium besylate, which preferably chromatographically separating cisatracurium besylate from a mixture of (1R,1?R)-atracurium isomers via flash chromatography.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: January 22, 2013
    Assignee: CHEMAGIS Ltd.
    Inventors: Oded Arad, Elena Ostrovsky
  • R,R-atracurium salts
    Patent number: 8354537
    Abstract: The present invention provides R,R?-atracurium salts, processes for producing and purifying such salts, and methods of using such salts to produce highly pure cisatracurium besylate.
    Type: Grant
    Filed: October 7, 2008
    Date of Patent: January 15, 2013
    Assignee: CHEMAGIS Ltd.
    Inventors: Oded Arad, Ofer Sharon, Elena Ostrovsky
  • Crystalline rotigotine base and preparation process therefor
    Patent number: 8344165
    Abstract: An isolated and pure crystalline rotigotine base of polymorph Form I, and processes for producing the crystalline rotigotine base are disclosed. Also disclosed is a transdermal patch for the delivery of rotigotine base using the disclosed isolated and pure form of rotigotine base, which can be used in treatment of Parkinson's Disease and other disorders ameliorated or treated by rotigotine, including restless leg syndrome.
    Type: Grant
    Filed: May 28, 2008
    Date of Patent: January 1, 2013
    Assignee: CHEMAGIS Ltd.
    Inventors: Sonia Krivonos, Alex Weisman
  • Palonosetron salts and processes for preparation and purification thereof
    Patent number: 8334388
    Abstract: Provided are novel salts of 2-(1-azabicyclo-[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one, methods of using such salts, and processes for producing such salts.
    Type: Grant
    Filed: May 28, 2008
    Date of Patent: December 18, 2012
    Assignee: Chemagis Ltd.
    Inventors: Tang Wensheng, Zhang Xingzhong, He Xungui, Yuan Wang, Joseph Kaspi
  • Process for producing cisatracurium compounds and associated intermediates
    Patent number: 8293912
    Abstract: The present invention provides processes for producing isoquinolinium compounds, and for converting them into cisatracurium salts, e.g.
    Type: Grant
    Filed: May 1, 2008
    Date of Patent: October 23, 2012
    Assignee: Chemagis Ltd.
    Inventors: Vladimir Naddaka, Shen Jingshan, Oded Arad, Guo Hongli, Ofer Sharon, Eyal Klopfer, Shady Saeed
  • STABLE HIGHLY PURE AZACITIDINE AND PREPARATION METHODS THEREFOR
    Publication number: 20110288042
    Abstract: Disclosed herein are methods of obtaining highly pure 5-azacytidine, which contains minimal amounts of degradation impurities and methods of assessing the impurity profile of the degradation of cytidine analogues, such as 5-azacytidine
    Type: Application
    Filed: July 23, 2008
    Publication date: November 24, 2011
    Applicant: CHEMAGIS LTD.
    Inventors: Alex Weisman, Lior Zelikovitch, Oded Friedman, Josef Manascu
  • NOVEL PROCESS FOR PREPARING HIGHLY PURE LEVOCETIRIZINE AND SALTS THEREOF
    Publication number: 20110230496
    Abstract: A process for preparing pure levocetirizine and salts thereof, e.g., the levocetirizine dihydrochloride, and a pharmaceutical composition comprising levocetirizine dihydrochloride produced by the process are disclosed.
    Type: Application
    Filed: August 4, 2008
    Publication date: September 22, 2011
    Applicant: CHEMAGIS LTD.
    Inventors: Lior Zelikovitch, Hila Shaked
  • CISATRACURIUM DERIVATIVES, PREPARATION AND USES THEREOF
    Publication number: 20110185796
    Abstract: The present invention provides compounds which are useful, e.g., as reference markers for analyzing the purity of cisatracurium and salts thereof, a test method for determining the said purity and processes for preparing reference markers.
    Type: Application
    Filed: April 28, 2009
    Publication date: August 4, 2011
    Applicant: CHEMAGIS Ltd.
    Inventors: Oded Arad, Vladimir Naddaka, Eyal Klopfer, Shady Saeed, Lior Shahar, Vitaly Shteinman
  • PROCESS FOR THE EPIMERIZATION OF ATOVAQUONE ISOMER, ATOVAQUONE INTERMEDIATES AND MIXTURE THEREOF
    Publication number: 20110144347
    Abstract: Provided is a process for the epimerization of the cis isomer of atovaquone, atovaquone intermediates and isomeric mixtures thereof into their corresponding trans-isomers resulting in higher yield of pure atovaquone.
    Type: Application
    Filed: June 30, 2008
    Publication date: June 16, 2011
    Applicant: CHEMAGIS LTD.
    Inventors: Fuqiang Zhu, Michel Bekhazi
  • PROCESS FOR PREPARING ATOVAQUONE AND ASSOCIATE INTERMEDIATES
    Publication number: 20110137041
    Abstract: The invention provides novel intermediates of atovaquone and use thereof for the preparation of atovaquone
    Type: Application
    Filed: June 30, 2008
    Publication date: June 9, 2011
    Applicant: CHEMAGIS LTD.
    Inventors: Fuqiang Zhu, He Qiao, Michel Bekhazi
  • Imiquimod production process
    Patent number: 7943771
    Abstract: Provided is a process for producing highly pure 4-amino-1-isobutyl-1H-imidazo[4,5-c]quinoline (imiquimod), which includes reacting 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline with a non-gaseous amine precursor. Also provided are methods for isolating highly pure imiquimod. Further provided are intermediates useful in the production of imiquimod, methods for producing such intermediates, and methods for obtaining imiquimod from such intermediates.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: May 17, 2011
    Assignee: Chemagis Ltd.
    Inventors: Vladimir Naddaka, Eyal Klopfer, Shady Saeed, Stephen Cherkez, Oded Arad
  • PROCESS FOR PRODUCING CISATRACURIUM AND ASSOCIATED INTERMEDIATES
    Publication number: 20100256381
    Abstract: The present invention provides a process of producing cisatracurium compounds, e.g., cisatracurium besylate, from isoquinolinium salts of the structural formula (VIIA) wherein X? is an anion and R is H or a C1-C6 alkyl, or an activated form of the carboxylic acid with 1,5-pentanediol to form a cisatracurium salt, optionally via an intermediate compound (VIII). The cisatracurium compounds can be purified using simple techniques to afford pure cisatracurium besylate without the need for HPLC purification.
    Type: Application
    Filed: May 1, 2008
    Publication date: October 7, 2010
    Applicant: CHEMAGIS LTD.
    Inventors: Oded Arad, Vladimir Naddaka, Eyal Klopfer, Shady Saeed, Ofer Sharon
  • NOVEL R,R`-ATRACURIUM SALTS
    Publication number: 20100234602
    Abstract: The present invention provides R,R?-atracurium salts processes for producing and purifying such salts, and methods of using such salts to produce highly pure cisatracurium besylate.
    Type: Application
    Filed: October 7, 2008
    Publication date: September 16, 2010
    Applicant: CHEMAGIS LTD.
    Inventors: Oded Arad, Ofer Sharon, Elena Ostrovsky
  • CRYSTALLINE ROTIGOTINE BASE AND PREPARATION PROCESS THEREFOR
    Publication number: 20100222602
    Abstract: An isolated and pure crystalline rotigotine base of polymorph Form I, and processes for producing the crystalline rotigotine base are disclosed. Also disclosed is a transdermal patch for the delivery of rotigotine base using the disclosed isolated and pure form of rotigotine base, which can be used in treatment of Parkinson's Disease and other disorders ameliorated or treated by rotigotine, including restless leg syndrome.
    Type: Application
    Filed: May 28, 2008
    Publication date: September 2, 2010
    Applicant: CHEMAGIS LTD.
    Inventors: Sonia Krivonos, Alex Weisman
  • Process for producing highly pure midazolam and salts thereof
    Patent number: 7776852
    Abstract: Provided is a process for producing highly pure midazolam and salts thereof, and a pharmaceutical composition containing the highly pure midazolam and/or a salt thereof.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: August 17, 2010
    Assignee: CHEMAGIS Ltd.
    Inventors: Sonia Krivonos, Yana Sery