Patents Assigned to CHEMAPOTHECA, LLC
  • Publication number: 20230321010
    Abstract: The invention also relates to processes for producing abuse deterrent pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
    Type: Application
    Filed: March 31, 2023
    Publication date: October 12, 2023
    Applicant: CHEMAPOTHECA, LLC
    Inventors: KARL POPP, HAROLD MECKLER
  • Patent number: 11717498
    Abstract: The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: August 8, 2023
    Assignees: Pharmapotheca A, Inc., Chemapotheca, LLC
    Inventors: Karl Popp, Harold Meckler
  • Patent number: 11123310
    Abstract: The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: September 21, 2021
    Assignees: Pharmapotheca, LLC, Chemapotheca, LLC
    Inventors: Karl Popp, Harold Meckler
  • Publication number: 20210030699
    Abstract: The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
    Type: Application
    Filed: October 9, 2020
    Publication date: February 4, 2021
    Applicants: Pharmapotheca, LLC, Chemapotheca, LLC
    Inventors: KARL POPP, HAROLD MECKLER
  • Publication number: 20200352883
    Abstract: The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
    Type: Application
    Filed: July 29, 2020
    Publication date: November 12, 2020
    Applicants: CHEMAPOTHECA, LLC, PHARMAPOTHECA, LLC
    Inventors: Karl Popp, Harold Meckler
  • Patent number: 10087202
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: October 2, 2018
    Assignee: CHEMAPOTHECA, LLC
    Inventors: Harold Meckler, Brian Gregg, Jie Yang
  • Patent number: 9657041
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: May 23, 2017
    Assignee: Chemapotheca, LLC
    Inventors: Harold Meckler, Brian Gregg, Jie Yang
  • Patent number: 9321794
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: April 26, 2016
    Assignee: CHEMAPOTHECA, LLC
    Inventors: Harold Meckler, Brian Thomas Gregg, Jie Yang
  • Patent number: 9278904
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: March 8, 2016
    Assignee: Chemapotheca, LLC
    Inventors: Harold Meckler, Brian Thomas Gregg, Jie Yang
  • Publication number: 20150183716
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions,
    Type: Application
    Filed: February 25, 2014
    Publication date: July 2, 2015
    Applicant: CHEMAPOTHECA, LLC
    Inventors: Harold Meckler, Brian Thomas Gregg, Jie Yang
  • Publication number: 20150183810
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
    Type: Application
    Filed: July 9, 2014
    Publication date: July 2, 2015
    Applicant: CHEMAPOTHECA, LLC
    Inventors: Harold Meckler, Brian Thomas Gregg, Jie Yang