Abstract: The invention relates to the identification of OR5A2 as an Olfactory Receptor that binds natural musk and synthetic musks. The invention encompasses the use of the interaction of OR5A2 polypeptides and nitromusk, polycyclic musk, macrocyclic musk and alicyclic musks as the basis of screening assays for agents that specifically modulate the activity of the OR of the invention.
Type:
Grant
Filed:
December 5, 2018
Date of Patent:
January 9, 2024
Assignee:
CHEMCOM S.A.
Inventors:
Sandra Huysseune, Alex Veithen, Yannick Quesnel
Abstract: The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.
Type:
Application
Filed:
June 1, 2022
Publication date:
December 1, 2022
Applicants:
CHEMCOM S.A., GIVAUDAN S.A.
Inventors:
Pierre Chatelain, Markus Gautschi, Thierry Granier, Yannick Quesnel, Charles Stanley Sell, Alex Veithen
Abstract: The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.
Type:
Grant
Filed:
January 30, 2018
Date of Patent:
July 12, 2022
Assignees:
CHEMCOM S.A., GIVAUDAN S.A.
Inventors:
Pierre Chatelain, Markus Gautschi, Thierry Granier, Yannick Quesnel, Charles Stanley Sell, Alex Veithen
Abstract: The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.
Type:
Application
Filed:
January 30, 2018
Publication date:
December 12, 2019
Applicants:
CHEMCOM S.A., GIVAUDAN S.A.
Inventors:
Pierre Chatelain, Markus Gautschi, Thierry Granier, Yannick Quesnel, Charles Stanley Sell, Alex Veithen
Abstract: The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the OR classification. The invention encompasses the use of the interaction of OR polypeptides and carboxylic acids as the basis of screening assays for agents that specifically modulate the activity of the seven ORs of the invention.
Abstract: The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the OR classification. The invention encompasses the use of the interaction of OR polypeptides and carboxylic acids as the basis of screening assays for agents that specifically modulate the activity of the seven ORs of the invention.
Abstract: The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the OR classification. The invention encompasses the use of the interaction of OR polypeptides and carboxylic acids as the basis of screening assays for agents that specifically modulate the activity of the seven ORs of the invention.
Abstract: The invention relates to the identification of isovaleric acid as a natural ligand of the RCC356 G-protein coupled receptor (GPCR). The invention encompasses the use of the interaction of RCC356 polypeptides and isovaleric acid as the basis of screening assays for agents that modulate the activity of the RCC356 receptor. The invention also encompasses diagnostic and other assays performed based upon the RCC356/isovaleric acid interaction, as well as kits for performing diagnostic and screening assays.
Type:
Grant
Filed:
May 12, 2008
Date of Patent:
August 30, 2011
Assignee:
Chemcom S.A.
Inventors:
Frédéric Sallman, Alex Veithen, Magali Philippeau
Abstract: The invention relates to the identification of isovaleric acid as a natural ligand of the RCC356 G-protein coupled receptor (GPCR). The invention encompasses the use of the interaction of RCC356 polypeptides and isovaleric acid as the basis of screening assays for agents that modulate the activity of the RCC356 receptor. The invention also encompasses diagnostic and other assays performed based upon the RCC356/isovaleric acid interaction, as well as kits for performing diagnostic and screening assays.
Type:
Application
Filed:
May 12, 2008
Publication date:
October 22, 2009
Applicant:
Chemcom S. A.
Inventors:
Frederic Sallman, Alex Veithen, Magali Philippeau
Abstract: The present invention in particular relates to in vitro methods to identify and/or confirm the binding and/or function of a volatile compound onto a membrane-integrated receptor using volatile-compound-Binding Protein (BP) or compositions thereof. Additionally, the present invention relates to kits comprising receptor proteins recognizing volatile compounds or a candidate receptor for said compound; and; BP, a complex or composition thereof. Said kits may be used to identify and/or confirm the binding and/or function of volatile compounds onto a membrane-integrated receptor.