Abstract: The present invention relates to a process for the preparation of pharmaceutically acceptable salts of (R,S)-S-adenosyl-L-methionine and allows to obtain the salified (R)-(+)-S-adenosyl-L-methionine diasteroisomer in amounts lower than or equal to 3% with respect to the salified (S)-(+)-S-adenosyl-L-methionine diastereoisomer; the salts that can be obtained by the process of the invention keep their configuration stable in time.
Type:
Grant
Filed:
May 13, 2002
Date of Patent:
October 25, 2005
Assignee:
Chementecno S.r.l.
Inventors:
Marco Berna, Lino Sivieri, Gianni Santambrogio, Ermanno Valoti
Abstract: The present invention relates to a process for the preparation of pharmaceutically acceptable salts of (SS,RS)-S-adenosyl-L-methionine and allows to obtain the salified (RS)-(+)-S-adenosyl-L-methionine diastereoisomer in amounts lower than or equal to 3% with respect to the salified (SS)-(+)-S-adenosyl-L-methionine diastereoisomer; the salts that can be obtained by the process of the invention keep their configuration stable in time.
Type:
Application
Filed:
April 11, 2001
Publication date:
January 24, 2002
Applicant:
CHEMENTECNO S.R.L.
Inventors:
Marco Berna, Lino Sivieri, Gianni Santambrogio, Ermanno Valoti
Abstract: Described is a process for preparing Amikacin wherein 1-N-(L(-).gamma.-benzyloxycarbonylamino-.alpha.-hyroxybutyryl)-3,6'-di-N-b enzyloxycarbonyl-Kanamycin A suspended in a suitable solvent, is treated with an aqueous solution of formic acid in the presence of a catalyst; the reaction mixture is charged on a ion exchange resin column to yield the desired product. Among the side-products Kanamycin A is obtained which is per se useful.
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