Abstract: Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, and their use in the treatment and/or prevention of diseases and disorders.
Type:
Grant
Filed:
March 11, 2011
Date of Patent:
January 26, 2016
Assignee:
CHEMIC LABORATORIES INC.
Inventors:
Joseph P. St. Laurent, Scott A. Goodrich, Gerald S. Jones, Jr.
Abstract: A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methlTHFA; and (4) isolating (6S)-5-methylTHFA.
Type:
Grant
Filed:
June 14, 2012
Date of Patent:
July 28, 2015
Assignee:
Chemic Laboratories Inc.
Inventors:
Gerald S. Jones, Jr., Joseph P. St. Laurent, Scott A. Goodrich, George Maguire
Abstract: Described herein are compositions (e.g., a pharmaceutical composition) and methods for controlling the delivery of a therapeutic agent, and their use in the treatment and/or prevention of diseases and disorders.
Type:
Application
Filed:
June 6, 2014
Publication date:
December 4, 2014
Applicant:
CHEMIC LABORATORIES INC.
Inventors:
Joseph P. St. Laurent, Scott A. Goodrich, Gerald S. Jones, Jr.
Abstract: A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methlTHFA; and (4) isolating (6S)-5-methylTHFA,
Type:
Application
Filed:
June 14, 2012
Publication date:
December 13, 2012
Applicant:
CHEMIC LABORATORIES INC.
Inventors:
Gerald S. Jones, JR., Joseph P. St. Laurent, Scott A. Goodrich, George Maguire
Abstract: The present invention provides a novel approach for the preparation of fatty alcohol esters of ?-hydroxy carboxylic acids. In one form of the invention, the target fatty alcohol ester of ?-hydroxy carboxylic acid is produced by converting a lower alkyl ester of ?-hydroxy carboxylic acid into a fatty alcohol ester of ?-hydroxy carboxylic acid via alcoholysis (i.e., transesterification). The transesterification process is an equilibrium reaction, catalyzed chemically (i.e., with acids or bases) or enzymatically, that is shifted in the desired direction to produce the desired product. One preferred way of shifting the reaction in the direction of the desired product is by reducing the concentration of one of the products (e.g., distillation of a lower-boiling alcohol as soon as it is formed). Another preferred way of shifting the reaction in the direction of the desired product is by increasing the concentration of one of the reactants (e.q., adding more of the starting ester).
Type:
Grant
Filed:
October 17, 2005
Date of Patent:
January 4, 2011
Assignee:
Chemic Laboratories, Inc.
Inventors:
Gerald S. Jones, Jr., Joseph P. St. Laurent, Scott A. Goodrich