Patents Assigned to CHEMICAL & BIOPHARMACEUTICALS LABORATORIES OF PATRAS S.A.
  • Amino diacids containing peptide modifiers
    Patent number: 11634455
    Abstract: The present invention relates to peptide modifier compounds of Formula (1), or a salt thereof, wherein: a is an integer from 1 to 10, more preferably from 1 to 3; b is an integer from 0 to 7; Z is a terminal group and Y is a bivalent group. Further aspects of the invention relate to intermediates in the preparation of compounds of Formula (1), and the use of compounds of Formula 1 in the synthesis of peptide derivatives.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: April 25, 2023
    Assignee: CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A.
    Inventors: Kleomenis Barlos, Dimitrios Gatos, Kostas K. Barlos, Zoi Vasileiou
  • Biologically active insulin derivatives
    Patent number: 10195287
    Abstract: A first aspect of the invention relates to a single chain insulin analog comprising: (A) the A-chain of human or animal insulin, or an analog or derivative thereof; (B) the B-chain of human or animal insulin, or an analog or derivative thereof; (C) one or more disulfide bonds between said A-chain and said B-chain; and (D) a further covalent link, L, between a functional group of an amino acid in the A-chain and a functional group of an amino acid in the B-chain, at least one of said functional groups being an amino acid side chain functional group. Further aspects of the invention relate to pharmaceutical compositions comprising said single chain insulin derivatives, and therapeutic uses thereof.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: February 5, 2019
    Assignee: CHEMICAL & BIOPHARMACEUTICALS LABORATORIES OF PATRAS S.A.
    Inventors: Kleomenis Barlos, Dimitrios Gatos, Kostas Barlos, Michail Ziovas
  • Solid phase peptide synthesis via side chain attachment
    Patent number: 10183966
    Abstract: The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy amino acids, hydroxy amino acid amides, hydroxy amino alcohols or small peptides containing hydroxy amino acids attached to polymers through their side chain.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: January 22, 2019
    Assignee: CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A.
    Inventor: Kleomenis K. Barlos
  • Solid phase peptide synthesis via side chain attachment
    Patent number: 9388212
    Abstract: The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy amino acids, hydroxy amino acid amides, hydroxy amino alcohols or small peptides containing hydroxy amino acids attached to polymers through their side chain.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: July 12, 2016
    Assignee: CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A.
    Inventor: Kleomenis K. Barlos
  • SOLID PHASE PEPTIDE SYNTHESIS VIA SIDE CHAIN ATTACHMENT
    Publication number: 20140235789
    Abstract: The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy amino acids, hydroxy amino acid amides, hydroxy amino alcohols or small peptides containing hydroxy amino acids attached to polymers through their side chain.
    Type: Application
    Filed: February 21, 2013
    Publication date: August 21, 2014
    Applicant: Chemical & Biopharmaceutical Laboratories of Patras S.A.
    Inventor: Chemical & Biopharmaceutical Laboratories of Patras S.A.