Patents Assigned to Chemie Grunenthal GmbH
  • Lactum drug compositions
    Patent number: 4067985
    Abstract: Drug compositions including a lactam of the substituted ortho-sulfobenzoic acid imido pyrrolidone-2, piperidone-2, or caprolactam type.The drug compositions have valuable therapeutic properties: they are immunouppressive, sedative and have antitumor activity. The method of inducing sedation in warmblooded animals.
    Type: Grant
    Filed: December 12, 1975
    Date of Patent: January 10, 1978
    Assignee: Chemie Grunenthal GmbH
    Inventors: Ivars Graudums, Heinrich Muckter, Ernst Frankus
  • Process for the manufacture of pyrimidine derivatives
    Patent number: 3980649
    Abstract: A process for the manufacture of 2,4-diamino-5-(substituted benzyl)pyrimidines from the corresponding 6-hydroxy-derivatives or the hydrochloride thereof by (a) chlorinating with phosphoryl chloride in presence of a considerable excess of hydrogen chloride and (b) hydrogenation of the thus easily in practically pure form and with high yields obtained 6-chloro derivatives.
    Type: Grant
    Filed: August 27, 1974
    Date of Patent: September 14, 1976
    Assignee: Chemie Grunenthal GmbH
    Inventor: Siegfried Herrling
  • Lactams and process for their manufacture
    Patent number: 3951985
    Abstract: Lactams of the substituted ortho-sulfobenzoic acid imido pyrrolidone-2, piperidone-2, or caprolactam type. The compounds are useful drugs having therapeutical properties. They are immunosuppressive, sedative, and have antitumor activity. They are produced, for instance, by reacting bromo-lactams with a metal salt of o-sulfobenzoic acid imide.
    Type: Grant
    Filed: February 27, 1973
    Date of Patent: April 20, 1976
    Assignee: Chemie Grunenthal GmbH
    Inventors: Ivars Graudums, Heinrich Muckter, Ernst Frankus