Patents Assigned to CHEMO RESEARCH, S.L.
  • Patent number: 11590145
    Abstract: The invention relates to vaginal composition comprising a combination of estrogen and vitamin D or a vitamin D analog at a daily dosage delivery of (i) estrogen ranging from 1 ?g to 100 ?g estrogen of estradiol equivalent and (ii) vitamin D or analog ranging from 7.5 ?g to 100 ?g of vitamin D equivalent.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: February 28, 2023
    Assignee: CHEMO RESEARCH S.L.
    Inventors: Enrico Colli, David F. Archer
  • Patent number: 10596155
    Abstract: The present disclosure provides mucoadhesive aqueous-based gel formulations of metronidazole useful for a variety of purposes including intravaginal application as a therapeutic approach towards the treatment of individuals suffering from and/or diagnosed with bacterial vaginosis.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: March 24, 2020
    Assignee: CHEMO RESEARCH, S.L.
    Inventors: Michael T. Nordsiek, Kodumudi S. Balaji
  • Publication number: 20190224213
    Abstract: The invention relates to vaginal composition comprising a combination of estrogen and vitamin D or a vitamin D analog at a daily dosage delivery of (i) estrogen ranging from 1 ?g to 100 ?g estrogen of estradiol equivalent and (ii) vitamin D or analog ranging from 7.5 ?g to 100 ?g of vitamin D equivalent.
    Type: Application
    Filed: July 20, 2017
    Publication date: July 25, 2019
    Applicant: Chemo Research S.L..
    Inventors: Enrico COLLI, David F. ARCHER
  • Patent number: 10343984
    Abstract: The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N?-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the salt of the compound of formula (II) and a compound of formula (II) with a compound of formula (III), in the presence of a polar organic solvent; a crystalline solid form of the compound of formula (I), in particular crystalline solid form A; to a pharmaceutical composition comprising them; and to their use as a medicament, in particular to the treatment of a condition mediated by Rho-GTPase cell proteins.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: July 9, 2019
    Assignee: CHEMO RESEARCH. S.L.
    Inventor: José Amato
  • Publication number: 20190183859
    Abstract: The present disclosure provides mucoadhesive aqueous-based gel formulations of metronidazole useful for a variety of purposes including intravaginal application as a therapeutic approach towards the treatment of individuals suffering from and/or diagnosed with bacterial vaginosis.
    Type: Application
    Filed: January 14, 2019
    Publication date: June 20, 2019
    Applicant: CHEMO RESEARCH, S.L.
    Inventors: Michael T. Nordsiek, Kodumudi S. Balaji
  • Patent number: 10238634
    Abstract: The present disclosure provides mucoadhesive aqueous-based gel formulations of metronidazole useful for a variety of purposes, including intravaginal application as a therapeutic approach towards the treatment of individuals suffering from and/or diagnosed with bacterial vaginosis.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: March 26, 2019
    Assignee: CHEMO RESEARCH, S.L.
    Inventors: Michael T. Nordsiek, Kodumudi S. Balaji
  • Patent number: 9872829
    Abstract: It relates to a device comprising (a) a core comprising polyurethane; (b) a sheath comprising ethylene vinyl acetate copolymer, said sheath substantially or completely surrounding said core; and (c) one or more active pharmaceutical ingredients dissolved or dispersed in said core and/or said sheath; and to a process for its preparation.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: January 23, 2018
    Assignee: Chemo Research, S.L.
    Inventors: Andrew Loxley, Mark Mitchnick, Gonzalo Hernández Herrero, Celestino Ronchi
  • Patent number: 9745257
    Abstract: Provided herein are phenyl-guanidine derivatives for the inhibition of Rac1 which blocks its interaction with guanosine exchange factors (GEFs) belonging to the DBL family as agents for the treatment of aggressive and/or resistant tumors, as well as pharmaceutical compositions comprising them, their use in therapy and processes for their preparation.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: August 29, 2017
    Assignees: UNIVERSIDAD NACIONAL DE QUILMES, CHEMO RESEARCH, S.L.
    Inventors: Pablo Lorenzano Menna, Daniel Fernando Alonso, Daniel Eduardo Gómez, Julieta Comin
  • Patent number: 9718795
    Abstract: The invention relates to a process for the synthesis of Cariprazine, an antipsychotic compound useful in the treatment of positive and negative symptoms associated to schizophrenia, with the following structural formula: (A) The invention further relates to the synthesis of intermediates useful in the preparation of Cariprazine.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: August 1, 2017
    Assignee: CHEMO RESEARCH, S.L.
    Inventors: Maurizio Taddei, Elena Cini, Marcello Rasparini
  • Publication number: 20160000706
    Abstract: It relates to a device comprising (a) a core comprising polyurethane; (b) a sheath comprising ethylene vinyl acetate copolymer, said sheath substantially or completely surrounding said core; and (c) one or more active pharmaceutical ingredients dissolved or dispersed in said core and/or said sheath; and to a process for its preparation.
    Type: Application
    Filed: September 15, 2015
    Publication date: January 7, 2016
    Applicant: Chemo Research, S.L.
    Inventors: Andrew LOXLEY, Mark MITCHNICK, Gonzalo HERNÁNDEZ HERRERO, Celestino RONCHI
  • Patent number: 9132081
    Abstract: It relates to a device comprising (a) a core comprising polyurethane; (b) a sheath comprising ethylene vinyl acetate copolymer, said sheath substantially or completely surrounding said core; and (c) one or more active pharmaceutical ingredients dissolved or dispersed in said core and/or said sheath; and to a process for its preparation.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: September 15, 2015
    Assignee: CHEMO RESEARCH, S.L.
    Inventors: Andrew Loxley, Mark Mitchnick, Gonzalo Hernández Herrero, Celestino Ronchi
  • Publication number: 20140228388
    Abstract: Provided herein are phenyl-guanidine derivatives for the inhibition of Rac1 which blocks its interaction with guanosine exchange factors (GEFs) belonging to the DBL family as agents for the treatment of aggressive and/or resistant tumours, as well as pharmaceutical compositions comprising them, their use in therapy and processes for their preparation.
    Type: Application
    Filed: October 10, 2012
    Publication date: August 14, 2014
    Applicants: Universidad Nacional de Quilmes, Chemo Research, S.L.
    Inventors: Pablo Lorenzano Menna, Julieta Comín, Daniel Eduardo Gómez, Daniel Fernando Alonso
  • Publication number: 20130209539
    Abstract: It relates to a device comprising (a) a core comprising polyurethane; (b) a sheath comprising ethylene vinyl acetate copolymer, said sheath substantially or completely surrounding said core; and (c) one or more active pharmaceutical ingredients dissolved or dispersed in said core and/or said sheath; and to a process for its preparation.
    Type: Application
    Filed: February 13, 2013
    Publication date: August 15, 2013
    Applicant: CHEMO RESEARCH, S.L.
    Inventor: CHEMO RESEARCH, S.L.