Patents Assigned to CHEMO RESEARCH, S.L.
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Patent number: 11590145Abstract: The invention relates to vaginal composition comprising a combination of estrogen and vitamin D or a vitamin D analog at a daily dosage delivery of (i) estrogen ranging from 1 ?g to 100 ?g estrogen of estradiol equivalent and (ii) vitamin D or analog ranging from 7.5 ?g to 100 ?g of vitamin D equivalent.Type: GrantFiled: November 19, 2020Date of Patent: February 28, 2023Assignee: CHEMO RESEARCH S.L.Inventors: Enrico Colli, David F. Archer
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Patent number: 10596155Abstract: The present disclosure provides mucoadhesive aqueous-based gel formulations of metronidazole useful for a variety of purposes including intravaginal application as a therapeutic approach towards the treatment of individuals suffering from and/or diagnosed with bacterial vaginosis.Type: GrantFiled: January 14, 2019Date of Patent: March 24, 2020Assignee: CHEMO RESEARCH, S.L.Inventors: Michael T. Nordsiek, Kodumudi S. Balaji
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Publication number: 20190224213Abstract: The invention relates to vaginal composition comprising a combination of estrogen and vitamin D or a vitamin D analog at a daily dosage delivery of (i) estrogen ranging from 1 ?g to 100 ?g estrogen of estradiol equivalent and (ii) vitamin D or analog ranging from 7.5 ?g to 100 ?g of vitamin D equivalent.Type: ApplicationFiled: July 20, 2017Publication date: July 25, 2019Applicant: Chemo Research S.L..Inventors: Enrico COLLI, David F. ARCHER
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Patent number: 10343984Abstract: The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N?-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the salt of the compound of formula (II) and a compound of formula (II) with a compound of formula (III), in the presence of a polar organic solvent; a crystalline solid form of the compound of formula (I), in particular crystalline solid form A; to a pharmaceutical composition comprising them; and to their use as a medicament, in particular to the treatment of a condition mediated by Rho-GTPase cell proteins.Type: GrantFiled: August 10, 2016Date of Patent: July 9, 2019Assignee: CHEMO RESEARCH. S.L.Inventor: José Amato
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Publication number: 20190183859Abstract: The present disclosure provides mucoadhesive aqueous-based gel formulations of metronidazole useful for a variety of purposes including intravaginal application as a therapeutic approach towards the treatment of individuals suffering from and/or diagnosed with bacterial vaginosis.Type: ApplicationFiled: January 14, 2019Publication date: June 20, 2019Applicant: CHEMO RESEARCH, S.L.Inventors: Michael T. Nordsiek, Kodumudi S. Balaji
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Patent number: 10238634Abstract: The present disclosure provides mucoadhesive aqueous-based gel formulations of metronidazole useful for a variety of purposes, including intravaginal application as a therapeutic approach towards the treatment of individuals suffering from and/or diagnosed with bacterial vaginosis.Type: GrantFiled: October 23, 2015Date of Patent: March 26, 2019Assignee: CHEMO RESEARCH, S.L.Inventors: Michael T. Nordsiek, Kodumudi S. Balaji
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Patent number: 9872829Abstract: It relates to a device comprising (a) a core comprising polyurethane; (b) a sheath comprising ethylene vinyl acetate copolymer, said sheath substantially or completely surrounding said core; and (c) one or more active pharmaceutical ingredients dissolved or dispersed in said core and/or said sheath; and to a process for its preparation.Type: GrantFiled: September 15, 2015Date of Patent: January 23, 2018Assignee: Chemo Research, S.L.Inventors: Andrew Loxley, Mark Mitchnick, Gonzalo Hernández Herrero, Celestino Ronchi
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Patent number: 9745257Abstract: Provided herein are phenyl-guanidine derivatives for the inhibition of Rac1 which blocks its interaction with guanosine exchange factors (GEFs) belonging to the DBL family as agents for the treatment of aggressive and/or resistant tumors, as well as pharmaceutical compositions comprising them, their use in therapy and processes for their preparation.Type: GrantFiled: October 10, 2012Date of Patent: August 29, 2017Assignees: UNIVERSIDAD NACIONAL DE QUILMES, CHEMO RESEARCH, S.L.Inventors: Pablo Lorenzano Menna, Daniel Fernando Alonso, Daniel Eduardo Gómez, Julieta Comin
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Patent number: 9718795Abstract: The invention relates to a process for the synthesis of Cariprazine, an antipsychotic compound useful in the treatment of positive and negative symptoms associated to schizophrenia, with the following structural formula: (A) The invention further relates to the synthesis of intermediates useful in the preparation of Cariprazine.Type: GrantFiled: October 14, 2014Date of Patent: August 1, 2017Assignee: CHEMO RESEARCH, S.L.Inventors: Maurizio Taddei, Elena Cini, Marcello Rasparini
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Publication number: 20160000706Abstract: It relates to a device comprising (a) a core comprising polyurethane; (b) a sheath comprising ethylene vinyl acetate copolymer, said sheath substantially or completely surrounding said core; and (c) one or more active pharmaceutical ingredients dissolved or dispersed in said core and/or said sheath; and to a process for its preparation.Type: ApplicationFiled: September 15, 2015Publication date: January 7, 2016Applicant: Chemo Research, S.L.Inventors: Andrew LOXLEY, Mark MITCHNICK, Gonzalo HERNÁNDEZ HERRERO, Celestino RONCHI
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Patent number: 9132081Abstract: It relates to a device comprising (a) a core comprising polyurethane; (b) a sheath comprising ethylene vinyl acetate copolymer, said sheath substantially or completely surrounding said core; and (c) one or more active pharmaceutical ingredients dissolved or dispersed in said core and/or said sheath; and to a process for its preparation.Type: GrantFiled: February 13, 2013Date of Patent: September 15, 2015Assignee: CHEMO RESEARCH, S.L.Inventors: Andrew Loxley, Mark Mitchnick, Gonzalo Hernández Herrero, Celestino Ronchi
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Publication number: 20140228388Abstract: Provided herein are phenyl-guanidine derivatives for the inhibition of Rac1 which blocks its interaction with guanosine exchange factors (GEFs) belonging to the DBL family as agents for the treatment of aggressive and/or resistant tumours, as well as pharmaceutical compositions comprising them, their use in therapy and processes for their preparation.Type: ApplicationFiled: October 10, 2012Publication date: August 14, 2014Applicants: Universidad Nacional de Quilmes, Chemo Research, S.L.Inventors: Pablo Lorenzano Menna, Julieta Comín, Daniel Eduardo Gómez, Daniel Fernando Alonso
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Publication number: 20130209539Abstract: It relates to a device comprising (a) a core comprising polyurethane; (b) a sheath comprising ethylene vinyl acetate copolymer, said sheath substantially or completely surrounding said core; and (c) one or more active pharmaceutical ingredients dissolved or dispersed in said core and/or said sheath; and to a process for its preparation.Type: ApplicationFiled: February 13, 2013Publication date: August 15, 2013Applicant: CHEMO RESEARCH, S.L.Inventor: CHEMO RESEARCH, S.L.