Patents Assigned to Chemocentryx
  • Bis-aryl sulfonamides
    Patent number: 7227035
    Abstract: Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: June 5, 2007
    Assignee: Chemocentryx
    Inventors: Solomon Ungashe, Zheng Wei, J. J. Wright, Andrew Pennell, Brett Permack, Thomas Schall
  • Aryl sulfonamides
    Patent number: 6939885
    Abstract: Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: September 6, 2005
    Assignee: Chemocentryx
    Inventors: Solomon Ungashe, Zheng Wei, John Jessen Wright, Andrew Pennell
  • Anti-inflammatory compositions and methods of use
    Patent number: 6727241
    Abstract: The present invention is directed to pharmaceutical compositions containing active compounds, which inhibit the activity of the chemokines, MIP-1&agr; and RANTES. It also is directed to methods of treating inflammatory and immunoregulatory disorders and diseases using these pharmaceutical compositions.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: April 27, 2004
    Assignee: Chemocentryx
    Inventor: Brian McMaster
  • ANTI-INFLAMMATORY COMPOSITIONS AND METHODS OF USE
    Publication number: 20030236249
    Abstract: The present invention is directed to pharmaceutical compositions containing active compounds, which inhibit the activity of the chemokines, MIP-1 &agr; and RANTES. It also is directed to methods of treating inflammatory and immunoregulatory disorders and diseases using these pharmaceutical compositions.
    Type: Application
    Filed: June 12, 2002
    Publication date: December 25, 2003
    Applicant: Chemocentryx
    Inventor: Brian McMaster
  • Bicyclic compounds as inhibitors of chemokine binding to US28
    Publication number: 20030149055
    Abstract: Methods for treating CMV or a CMV-related disease are provided that use compounds having the formula: 1
    Type: Application
    Filed: August 29, 2002
    Publication date: August 7, 2003
    Applicant: ChemoCentryx
    Inventors: Brian E. McMaster, Thomas J. Schall, Mark Penfold, J. J. Wright, Daniel J. Dairaghi
  • Reagents and methods for the diagnosis of CMV dissemination
    Publication number: 20020193374
    Abstract: Methods are provided for detecting the spread of cytomegalovirus in a host infected with CMV, by administering to the host a detectable and labeled amount of a non-endogenous compound which binds to US28 or a US28 fragment. Typically, the methods use a labeled form of IBZM.
    Type: Application
    Filed: August 30, 2001
    Publication date: December 19, 2002
    Applicant: ChemoCentryx
    Inventors: Thomas J. Schall, Brian E. McMaster, Daniel J. Dairaghi
  • Chemomagnetic retrieval of CMV and CMV infected cells
    Publication number: 20020182594
    Abstract: Methods and apparatus are provided herein for collecting CMV and/or CMV infected cells from a host infected with CMV. Such methods and apparatus have utility in tracking the dissemination or infection of the host, use as an in vivo or ex vivo collection mechanism to measure mutation rates and selective pressures after in vivo passage, and in therapeutic treatments in which CMV and/or CMV infected cells are removed from a host.
    Type: Application
    Filed: February 1, 2002
    Publication date: December 5, 2002
    Applicant: ChemoCentryx
    Inventors: Thomas J. Schall, Mark E.T. Penfold
  • Modulators of US 28
    Publication number: 20020127544
    Abstract: Assays, compositions and methods of treatment are provided for modulating the binding of chemokines to US28 on the surface of cells.
    Type: Application
    Filed: August 30, 2001
    Publication date: September 12, 2002
    Applicant: ChemoCentryx
    Inventors: Thomas J. Schall, Brian E. McMaster, Daniel J. Dairaghi