Patents Assigned to Chempaq A/S
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Publication number: 20110318774Abstract: The present invention relates to an apparatus for characterizing particles suspended in a liquid, especially a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. Furthermore, the present invention relates to a method for characterizing particles in liquid and a device for sampling a small and accurate volume of liquid. The apparatus comprises a housing having a mixing chamber and a collection chamber separated by a wall containing an opening, a first bore in the outer surface of the housing for entrance of a liquid sample, a first cavity for receiving and holding a first liquid sample, and a second cavity for receiving and holding a second liquid sample.Type: ApplicationFiled: September 7, 2011Publication date: December 29, 2011Applicant: CHEMPAQ A/SInventor: Ulrik Darling Larsen
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Patent number: 8028566Abstract: The present invention relates to an apparatus for characterizing particles suspended in a liquid, especially a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. Furthermore, the present invention relates to a method for characterizing particles in liquid and a device for sampling a small and accurate volume of liquid. The apparatus comprises a housing having a mixing chamber and a collection chamber separated by a wall containing an opening, a first bore in the outer surface of the housing for entrance of a liquid sample, a first cavity for receiving and holding a first liquid sample, and a second cavity for receiving and holding a second liquid sample.Type: GrantFiled: February 10, 2006Date of Patent: October 4, 2011Assignee: Chempaq A/SInventor: Ulrik Darling Larsen
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Patent number: 7968052Abstract: An apparatus which enables characterization of particles suspended in a liquid includes a housing with a mixing chamber and a collection chamber separated by a wall containing an aperture for passage of particles between, the mixing chamber and the collection chamber, the mixing chamber further containing a mixing member, a first electrode in the mixing chamber and a second electrode in the collection chamber for conduction of an electrical current through the aperture, a processor that is adapted for controlling the measurement sequence of the apparatus and detecting possible blockage of the aperture by detecting extended duration of the electrical pulse caused by the blocking particle, and upon detection of a blockage, reversing the liquid flow while mixing in the mixing chamber for removal of the blocking particle, and restarting particle counting.Type: GrantFiled: September 19, 2006Date of Patent: June 28, 2011Assignee: Chempaq A/SInventors: Rune Funder Mikkelsen, Ulrik Darling Larsen
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Patent number: 7928718Abstract: A method of calibration of a particle characterization apparatus, and a particle characterization apparatus, in which particles suspended in a liquid are passed through an orifice one by one for characterization of the particles, for instance by Coulter counting. The calibration does not require utilization of special calibration particles or liquids. A priori knowledge of the shape of a typical size distribution of a blood sample is utilized to adjust the apparatus based on an initial relatively short counting period of the sample in question. The initially determined size distribution is compared to the corresponding known typical size distribution and the apparatus is subsequently adjusted to counteract possible differences. Upon adjustment of the apparatus, the remaining part of the sample is passed through the orifice for determination of the actual particle size distribution of the remaining sample.Type: GrantFiled: September 30, 2005Date of Patent: April 19, 2011Assignee: Chempaq A/SInventor: Ulrik Darling Larsen
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Publication number: 20110027825Abstract: The present invention relates to a method of determining pulse height distribution by using an apparatus comprising: an analogue to digital pulses height categorisation unit comparing the pulse to analogue threshold voltages and counting each event within each pulse height category using a micro controller. The method may comprise the steps of i) selecting a first set of threshold voltages, ii) performing a first measurement using the first set of threshold voltages, iii) selecting a new set of threshold voltages different from the first set of threshold voltages, iv) performing a new measurement using the new set of threshold voltages, v) determining cell size distribution based on the first measurement and the new measurement.Type: ApplicationFiled: March 2, 2009Publication date: February 3, 2011Applicant: CHEMPAQ A/SInventor: Ulrik Darling Larsen
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Patent number: 7797990Abstract: A particle characterization apparatus in which particles suspended in a liquid pass through an orifice or aperture for detection and characterization of the particles utilizing impedance determination. In particular, the apparatus includes a membrane of a polymer as a base material for precision machining of a sub-millimeter orifice. Forming the orifice in a polymer membrane facilitates the construction of a single use cartridge for haematology analysis due to low material and production costs.Type: GrantFiled: June 11, 2003Date of Patent: September 21, 2010Assignee: Chempaq A/SInventors: Ulrik Darling Larsen, Preben Merrild Elkjær
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Patent number: 7771658Abstract: A disposable cartridge for characterizing particles suspended in a liquid, especially a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. The self-contained disposable cartridge facilitates a straightforward testing procedure, which can be performed by most people without any particular education. Furthermore, the apparatus used to perform the test on the cartridge is simple, maintenance free, and portable.Type: GrantFiled: June 11, 2003Date of Patent: August 10, 2010Assignee: Chempaq A/SInventor: Ulrik Darling Larsen
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Patent number: 7701193Abstract: A pulse height analyzer for determination of the pulse height distribution of electronic pulses includes a set of comparators with a common input for analogue to digital conversion of the electronic pulses, a set of latches wherein the inputs of the latches are connected to the outputs of respective comparators for recording passage of the corresponding threshold voltages by the rising edge of a pulse, a priority encoder connected to the latch outputs for determination of a pulse height category consisting of pulses with a pulse height within a pulse height interval defined by respective threshold voltages, and a micro controller that is adapted to count the number of pulses within each pulse height category.Type: GrantFiled: August 27, 2004Date of Patent: April 20, 2010Assignee: Chempaq A/SInventors: Freddy Petersen, Rune Funder Mikkelsen, Morten Wilsbech
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Publication number: 20080314130Abstract: The present invention relates to a particle characterisation apparatus in which particles suspended in a liquid are passed through an aperture, in principle one by one, to enable characterisation of the particles, for instance by Coulter counting.Type: ApplicationFiled: September 19, 2006Publication date: December 25, 2008Applicant: CHEMPAQ A/SInventors: Rune Funder Mikkelsen, Ulrik Darling Larsen
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Publication number: 20080202217Abstract: The present invention relates to an apparatus for characterizing particles suspended in a liquid, especially a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. Furthermore, the present invention relates to a method for characterizing particles in liquid and a device for sampling a small and accurate volume of liquid. The apparatus comprises a housing having a mixing chamber and a collection chamber separated by a wall containing an opening, a first bore in the outer surface of the housing for entrance of a liquid sample, a first cavity for receiving and holding a first liquid sample, and a second cavity for receiving and holding a second liquid sample.Type: ApplicationFiled: February 10, 2006Publication date: August 28, 2008Applicant: CHEMPAQ A/SInventor: Ulrik Darling Larsen
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Patent number: 6959618Abstract: An apparatus is provided for characterizing cells in a biological liquid sample and operating according to the Coulter principle. The apparatus has a disposable sensor unit and a docking station for removably receiving the sensor unit. The sensor unit housing contains electrodes in each of two chambers separated by a wall containing an orifice. The housing is adapted to contain and retain for disposal liquid pumped through the orifice during particle characterization operations.Type: GrantFiled: August 3, 2000Date of Patent: November 1, 2005Assignee: Chempaq A/SInventor: Ulrik Darling Larsen