Abstract: Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, methods of making compounds of formula (I) and their use in the treatment and/or prevention of diseases and disorders.
Type:
Grant
Filed:
November 12, 2015
Date of Patent:
May 9, 2017
Assignee:
CHEMSMART, LLC
Inventors:
Joseph P. St. Laurent, Scott A. Goodrich, Gerald S. Jones, Jr.
Abstract: Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, methods of making compounds of formula (I) and their use in the treatment and/or prevention of diseases and disorders.
Type:
Grant
Filed:
September 16, 2011
Date of Patent:
April 19, 2016
Assignee:
CHEMSMART, LLC
Inventors:
Joseph P. St. Laurent, Scott A. Goodrich, Gerald S. Jones, Jr.
Abstract: The present invention provides a novel approach for the preparation of fatty alcohol esters of ?-hydroxy carboxylic acids. In one form of the invention, the target fatty alcohol ester of ?-hydroxy carboxylic acid is produced by converting a lower alkyl ester of ?-hydroxy carboxylic acid into a fatty alcohol ester of ?-hydroxy carboxylic acid via alcoholysis (i.e., transesterification). The transesterification process is an equilibrium reaction, catalyzed chemically (i.e., with acids or bases) or enzymatically, that is shifted in the desired direction to produce the desired product. One way of shifting the reaction in the direction of the desired product is by reducing the concentration of one of the products (e.g., distillation of a lower-boiling alcohol as it is formed). Another preferred way of shifting the reaction in the direction of the desired product is by increasing the concentration of one of the reactants.
Type:
Grant
Filed:
April 11, 2012
Date of Patent:
January 20, 2015
Assignee:
Chemsmart, LLC
Inventors:
Gerald S. Jones, Jr., Scott A. Goodrich, Joseph P. St. Laurent
Abstract: Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, methods of making compounds of formula (I) and their use in the treatment and/or prevention of diseases and disorders.
Type:
Application
Filed:
September 16, 2011
Publication date:
July 11, 2013
Applicant:
CHEMSMART, LLC
Inventors:
Joseph P. St. Laurent, Scott A. Goodrich, Gerald S. Jones, JR.