Abstract: The disclosure provides compounds and pharmaceutically acceptable salts thereof of Formula (I) The variables, R, R!-R3 and the A-ring are described herein. A can be a cyclohexyl ring. The compounds are inhibitors of JAK1 Kinase and are useful in methods of treating an allergic, inflammatory, or autoimmune disorders, in a patient, comprising administering a therapeutically effective amount of compound of Formula I or salt thereof, to the patient. The disclosure also provides pharmaceutical formulations containing a compound of Formula I.
Type:
Grant
Filed:
August 25, 2020
Date of Patent:
December 9, 2025
Assignee:
CHEMWERTH, INC.
Inventors:
Xiping Su, Sidney Xi Liang, Peter J. Werth