Abstract: A fluid handling port array includes at least one fluid conduction bore, a plurality of insert bores each intersecting at least one fluid conduction bore and being adapted to receive a configuration insert, a plurality of port bores each intersecting at least one of the fluid conduction bores for providing fluid access to the fluid conduction bores. The port array is configured by fixing configuration inserts in the insert bores. In a particular embodiment, the configuration inserts comprise device seats and are adapted to receive configuration devices such as a valves, caps or plugs. Alternatively, the configuration inserts, themselves, embody configuration devices.