Patents Assigned to Chiasma, Inc.
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Patent number: 11052126Abstract: Methods of treating acromegaly in a subject are described herein. Exemplary methods include orally administering to the subject at least once daily at least one dosage form comprising octreotide, wherein the octreotide in each dosage form is 20 mg, and wherein the administering occurs at least 1 hour before a meal or at least 2 hours after a meal.Type: GrantFiled: May 22, 2020Date of Patent: July 6, 2021Assignee: Chiasma, Inc.Inventors: Roni Mamluk, Sam L. Teichman
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Patent number: 10993984Abstract: Methods are disclosed of treating or preventing hypotension (e.g., neurogenic orthostatic hypotension or postprandial hypotension) or portal hypertension (e.g., bleeding esophageal varices associated with portal hypertension) or ascites (e.g., ascites associated with liver cirrhosis), by oral administration to affected subjects of compositions comprising a therapeutically effective amount of terlipressin or a pharmaceutically acceptable salt thereof.Type: GrantFiled: October 20, 2017Date of Patent: May 4, 2021Assignee: Chiasma, Inc.Inventor: Gary Patou
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Patent number: 10695397Abstract: Methods of treating acromegaly in a subject are described herein. Exemplary methods include orally administering to the subject at least once daily at least one dosage form comprising octreotide, wherein the octreotide in each dosage form is 20 mg, and wherein the administering occurs at least 1 hour before a meal or at least 2 hours after a meal.Type: GrantFiled: December 27, 2018Date of Patent: June 30, 2020Assignee: Chiasma, Inc.Inventors: Roni Mamluk, Sam L. Teichman
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Patent number: 10682387Abstract: This invention relates to combination therapy of a subject suffering from acromegaly. The method of treatment comprises administration to the subject of a therapeutically effective amount of oral somatostatin receptor ligand (SRL) e.g. octreotide in combination with a therapeutically effective amount of a dopamine agonist and/or a growth hormone receptor antagonist and/or a selective estrogen receptor modulator (SERM) and/or a 2nd somatostatin receptor ligand (SRL).Type: GrantFiled: May 7, 2018Date of Patent: June 16, 2020Assignee: Chiasma, Inc.Inventor: Asi Haviv
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Patent number: 10238709Abstract: Methods of treating acromegaly in a subject are described herein. Exemplary methods include orally administering to the subject at least once daily at least one dosage form comprising octreotide, wherein the octreotide in each dosage form is 20 mg, and wherein the administering occurs at least 1 hour before a meal or at least 2 hours after a meal.Type: GrantFiled: February 3, 2016Date of Patent: March 26, 2019Assignee: Chiasma, Inc.Inventors: Roni Mamluk, Sam L. Teichman
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Patent number: 9867760Abstract: An overlay is provided for a medication card of the type having a plurality of pharmaceutical products arranged in at least one row. The overlay includes a planar body having a front surface, and a plurality of openings formed in the planar body, with locations of the plurality of openings substantially corresponding to locations of the plurality of products of the medication card. The overlay further includes instructions provided on the front surface of the body for ingesting the plurality of products of the medication card.Type: GrantFiled: March 30, 2017Date of Patent: January 16, 2018Assignee: CHIASMA INC.Inventor: Dana Gelbaum
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Patent number: 9642773Abstract: An overlay is provided for a medication card of the type having a plurality of pharmaceutical products arranged in at least one row. The overlay includes a planar body having a front surface, and a plurality of openings formed in the planar body, with locations of the plurality of openings substantially corresponding to locations of the plurality of products of the medication card. The overlay further includes instructions provided on the front surface of the body for ingesting the plurality of products of the medication card.Type: GrantFiled: February 3, 2015Date of Patent: May 9, 2017Assignee: CHIASMA INC.Inventor: Dana Gelbaum
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Patent number: 9566246Abstract: The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.Type: GrantFiled: February 16, 2016Date of Patent: February 14, 2017Assignee: CHIASMA INC.Inventors: Roni Mamluk, Moshe Tzabari, Karen Marom, Paul Salama, Irina Weinstein
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Publication number: 20160193285Abstract: This invention relates to combination therapy of a subject suffering from acromegaly. The method of treatment comprises administration to the subject of a therapeutically effective amount of oral somatostatin receptor ligand (SRL) e.g. octreotide in combination with a therapeutically effective amount of a dopamine agonist and/or a growth hormone receptor antagonist and/or a selective estrogen receptor modulator (SERM) and/or a 2nd somatostatin receptor ligand (SRL).Type: ApplicationFiled: December 10, 2015Publication date: July 7, 2016Applicant: CHIASMA INC.Inventor: Asi Haviv
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Publication number: 20160030568Abstract: This invention relates to novel penetrating compositions including one or more effectors included within a water soluble composition, immersed in a hydrophobic medium. The invention also relates to methods of treating or preventing diseases by administering such penetrating compositions to affected subjects.Type: ApplicationFiled: April 22, 2014Publication date: February 4, 2016Applicant: CHIASMA INC.Inventor: Shmuel A. Ben-Sasson
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Publication number: 20150031631Abstract: The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.Type: ApplicationFiled: February 24, 2014Publication date: January 29, 2015Applicant: CHIASMA INC.Inventors: Roni Mamluk, Moshe Tzabari, Karen Marom, Paul Salama, Irina Weinstein
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Patent number: 8535695Abstract: The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.Type: GrantFiled: September 15, 2011Date of Patent: September 17, 2013Assignee: Chiasma Inc.Inventors: Paul Salama, Roni Mamluk, Karen Marom, Irina Weinstein, Moshe Tzabari
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Patent number: 8329198Abstract: The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.Type: GrantFiled: October 25, 2011Date of Patent: December 11, 2012Assignee: Chiasma Inc.Inventors: Paul Salama, Roni Mamluk, Karen Marom, Irina Weinstein, Moshe Tzabari
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Patent number: 8241670Abstract: This invention relates to novel penetrating compositions including one or more effectors included within a water soluble composition, immersed in a hydrophobic medium The invention also relates to methods of treating or preventing diseases by administering such penetrating compositions to affected subjects.Type: GrantFiled: April 14, 2005Date of Patent: August 14, 2012Assignee: Chiasma Inc.Inventor: Shmuel A. Ben-Sasson
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Publication number: 20060251713Abstract: This invention relates to novel pharmaceutical penetration compositions capable of facilitating penetration of at least one effector across biological barriers. The invention also relates to methods of treating or preventing diseases by administering penetration compositions to affected subjects.Type: ApplicationFiled: July 18, 2006Publication date: November 9, 2006Applicant: Chiasma, Inc.Inventors: Shmuel Ben-Sasson, Einat Cohen
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Patent number: 7115707Abstract: This invention relates to novel pharmaceutical penetration compositions capable of facilitating penetration of at least one effector across biological barriers. The invention also relates to methods of treating or preventing diseases by administering penetration compositions to affected subjects.Type: GrantFiled: September 17, 2003Date of Patent: October 3, 2006Assignee: Chiasma, Inc.Inventors: Shmuel A. Ben-Sasson, Einat Cohen
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Patent number: D770303Type: GrantFiled: February 3, 2015Date of Patent: November 1, 2016Assignee: CHIASMA INC.Inventor: Dana Gelbaum
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Patent number: D806570Type: GrantFiled: September 28, 2016Date of Patent: January 2, 2018Assignee: CHIASMA INC.Inventor: Dana Gelbaum