Patents Assigned to Chiasma, Inc.
  • Patent number: 11052126
    Abstract: Methods of treating acromegaly in a subject are described herein. Exemplary methods include orally administering to the subject at least once daily at least one dosage form comprising octreotide, wherein the octreotide in each dosage form is 20 mg, and wherein the administering occurs at least 1 hour before a meal or at least 2 hours after a meal.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: July 6, 2021
    Assignee: Chiasma, Inc.
    Inventors: Roni Mamluk, Sam L. Teichman
  • Patent number: 10993984
    Abstract: Methods are disclosed of treating or preventing hypotension (e.g., neurogenic orthostatic hypotension or postprandial hypotension) or portal hypertension (e.g., bleeding esophageal varices associated with portal hypertension) or ascites (e.g., ascites associated with liver cirrhosis), by oral administration to affected subjects of compositions comprising a therapeutically effective amount of terlipressin or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: May 4, 2021
    Assignee: Chiasma, Inc.
    Inventor: Gary Patou
  • Patent number: 10695397
    Abstract: Methods of treating acromegaly in a subject are described herein. Exemplary methods include orally administering to the subject at least once daily at least one dosage form comprising octreotide, wherein the octreotide in each dosage form is 20 mg, and wherein the administering occurs at least 1 hour before a meal or at least 2 hours after a meal.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: June 30, 2020
    Assignee: Chiasma, Inc.
    Inventors: Roni Mamluk, Sam L. Teichman
  • Patent number: 10682387
    Abstract: This invention relates to combination therapy of a subject suffering from acromegaly. The method of treatment comprises administration to the subject of a therapeutically effective amount of oral somatostatin receptor ligand (SRL) e.g. octreotide in combination with a therapeutically effective amount of a dopamine agonist and/or a growth hormone receptor antagonist and/or a selective estrogen receptor modulator (SERM) and/or a 2nd somatostatin receptor ligand (SRL).
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: June 16, 2020
    Assignee: Chiasma, Inc.
    Inventor: Asi Haviv
  • Patent number: 10238709
    Abstract: Methods of treating acromegaly in a subject are described herein. Exemplary methods include orally administering to the subject at least once daily at least one dosage form comprising octreotide, wherein the octreotide in each dosage form is 20 mg, and wherein the administering occurs at least 1 hour before a meal or at least 2 hours after a meal.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: March 26, 2019
    Assignee: Chiasma, Inc.
    Inventors: Roni Mamluk, Sam L. Teichman
  • Patent number: 9867760
    Abstract: An overlay is provided for a medication card of the type having a plurality of pharmaceutical products arranged in at least one row. The overlay includes a planar body having a front surface, and a plurality of openings formed in the planar body, with locations of the plurality of openings substantially corresponding to locations of the plurality of products of the medication card. The overlay further includes instructions provided on the front surface of the body for ingesting the plurality of products of the medication card.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: January 16, 2018
    Assignee: CHIASMA INC.
    Inventor: Dana Gelbaum
  • Patent number: 9642773
    Abstract: An overlay is provided for a medication card of the type having a plurality of pharmaceutical products arranged in at least one row. The overlay includes a planar body having a front surface, and a plurality of openings formed in the planar body, with locations of the plurality of openings substantially corresponding to locations of the plurality of products of the medication card. The overlay further includes instructions provided on the front surface of the body for ingesting the plurality of products of the medication card.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: May 9, 2017
    Assignee: CHIASMA INC.
    Inventor: Dana Gelbaum
  • Patent number: 9566246
    Abstract: The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: February 14, 2017
    Assignee: CHIASMA INC.
    Inventors: Roni Mamluk, Moshe Tzabari, Karen Marom, Paul Salama, Irina Weinstein
  • Publication number: 20160193285
    Abstract: This invention relates to combination therapy of a subject suffering from acromegaly. The method of treatment comprises administration to the subject of a therapeutically effective amount of oral somatostatin receptor ligand (SRL) e.g. octreotide in combination with a therapeutically effective amount of a dopamine agonist and/or a growth hormone receptor antagonist and/or a selective estrogen receptor modulator (SERM) and/or a 2nd somatostatin receptor ligand (SRL).
    Type: Application
    Filed: December 10, 2015
    Publication date: July 7, 2016
    Applicant: CHIASMA INC.
    Inventor: Asi Haviv
  • Publication number: 20160030568
    Abstract: This invention relates to novel penetrating compositions including one or more effectors included within a water soluble composition, immersed in a hydrophobic medium. The invention also relates to methods of treating or preventing diseases by administering such penetrating compositions to affected subjects.
    Type: Application
    Filed: April 22, 2014
    Publication date: February 4, 2016
    Applicant: CHIASMA INC.
    Inventor: Shmuel A. Ben-Sasson
  • Publication number: 20150031631
    Abstract: The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.
    Type: Application
    Filed: February 24, 2014
    Publication date: January 29, 2015
    Applicant: CHIASMA INC.
    Inventors: Roni Mamluk, Moshe Tzabari, Karen Marom, Paul Salama, Irina Weinstein
  • Patent number: 8535695
    Abstract: The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: September 17, 2013
    Assignee: Chiasma Inc.
    Inventors: Paul Salama, Roni Mamluk, Karen Marom, Irina Weinstein, Moshe Tzabari
  • Patent number: 8329198
    Abstract: The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: December 11, 2012
    Assignee: Chiasma Inc.
    Inventors: Paul Salama, Roni Mamluk, Karen Marom, Irina Weinstein, Moshe Tzabari
  • Patent number: 8241670
    Abstract: This invention relates to novel penetrating compositions including one or more effectors included within a water soluble composition, immersed in a hydrophobic medium The invention also relates to methods of treating or preventing diseases by administering such penetrating compositions to affected subjects.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: August 14, 2012
    Assignee: Chiasma Inc.
    Inventor: Shmuel A. Ben-Sasson
  • Publication number: 20060251713
    Abstract: This invention relates to novel pharmaceutical penetration compositions capable of facilitating penetration of at least one effector across biological barriers. The invention also relates to methods of treating or preventing diseases by administering penetration compositions to affected subjects.
    Type: Application
    Filed: July 18, 2006
    Publication date: November 9, 2006
    Applicant: Chiasma, Inc.
    Inventors: Shmuel Ben-Sasson, Einat Cohen
  • Patent number: 7115707
    Abstract: This invention relates to novel pharmaceutical penetration compositions capable of facilitating penetration of at least one effector across biological barriers. The invention also relates to methods of treating or preventing diseases by administering penetration compositions to affected subjects.
    Type: Grant
    Filed: September 17, 2003
    Date of Patent: October 3, 2006
    Assignee: Chiasma, Inc.
    Inventors: Shmuel A. Ben-Sasson, Einat Cohen
  • Patent number: D770303
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: November 1, 2016
    Assignee: CHIASMA INC.
    Inventor: Dana Gelbaum
  • Patent number: D806570
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: January 2, 2018
    Assignee: CHIASMA INC.
    Inventor: Dana Gelbaum