Patents Assigned to Chienna B.V.
  • Publication number: 20070254103
    Abstract: The invention relates to a coating for medical devices. The coating comprises a specific copolymer of which the composition may be adjusted such as to achieve an excellent adhesion to a wide range of surfaces. The coating may further comprise an additive, such as a biologically active agent, which may be released in vivo in a controlled manner, as the degradability of the coating may also be adjusted to a predetermined rate. The invention further relates to a process for applying the coating to a surface and to a medical device comprising the coating.
    Type: Application
    Filed: April 26, 2007
    Publication date: November 1, 2007
    Applicant: Chienna B.V.
    Inventors: Jerome Sohier, Jeroen Bezemer
  • Patent number: 7226612
    Abstract: The invention relates to a coating for medical devices. The coating comprises a specific copolymer of which the composition may be adjusted such as to achieve an excellent adhesion to a wide range of surfaces. The coating may further comprise an additive, such as a biologically active agent, which may be released in vivo in a controlled manner, as the degradability of the coating may also be adjusted to a predetermined rate. The invention further relates to a process for applying the coating to a surface and to a medical device comprising the coating.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: June 5, 2007
    Assignee: Chienna B.V.
    Inventors: Jerome Sohier, Jeroen Mattijs Bezemer
  • Publication number: 20060258835
    Abstract: The invention relates to a poly(ether ester) multiblock copolymer material based on a combination of a poly(alkylene glycol) component, a short chain diol, an aromatic dicarboxylic acid or derivative thereof and at least one type of non-aromatic dicarboxylic acid or derivative thereof. The invention further relates to a process for the preparation of the polymeric material, a medical device comprising said polymeric material and the use of the medical device for the preparation of a medicament for guided tissue regeneration, as a scaffold for engineering tissue in vitro, or as a matrix for controlled release of a (bio)active substance.
    Type: Application
    Filed: March 23, 2006
    Publication date: November 16, 2006
    Applicant: Chienna B.V.
    Inventors: Jeroen Bezemer, Jorg Roosma, Riemke van Dijkhuizen-Radersma, Joost de Wijn
  • Publication number: 20050101692
    Abstract: The invention relates to a coating for medical devices. The coating comprises a specific copolymer of which the composition may be adjusted such as to achieve an excellent adhesion to a wide range of surfaces. The coating may further comprise an additive, such as a biologically active agent, which may be released in vivo in a controlled manner, as the degradability of the coating may also be adjusted to a predetermined rate. The invention further relates to a process for applying the coating to a surface and to a medical device comprising the coating.
    Type: Application
    Filed: September 25, 2003
    Publication date: May 12, 2005
    Applicant: Chienna B.V.
    Inventors: Jerome Sohier, Jeroen Bezemer
  • Publication number: 20050063941
    Abstract: The invention relates to a poly(ether ester) multiblock copolymer material based on a combination of a poly(alkylene glycol) component, a short chain diol, an aromatic dicarboxylic acid or derivative thereof and at least one type of non-aromatic dicarboxylic acid or derivative thereof. The invention further relates to a process for the preparation of the polymeric material, a medical device comprising said polymeric material and the use of the medical device for the preparation of a medicament for guided tissue regeneration, as a scaffold for engineering tissue in vitro, or as a matrix for controlled release of a (bio)active substance.
    Type: Application
    Filed: August 26, 2004
    Publication date: March 24, 2005
    Applicant: Chienna B.V.
    Inventors: Jeroen Bezemer, Jorg Roosma, Riemke van Dijkhuizen-Radersma, Joost de Wijn
  • Patent number: 6835391
    Abstract: The invention relates to new biologically degradable aliphatic copolymers of the polyesteramide or polyesterurethane type. The invention further relates to a method for preparing the copolymers and to products which can be manufactured from the new copolymers.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: December 28, 2004
    Assignee: Chienna B.V.
    Inventors: Jeroen Mattijs Bezemer, Jan Feijen, Pieter Jelle Dijkstra
  • Publication number: 20040086544
    Abstract: The invention relates to a process for loading a polymer with one or more bioactive agents, using a wet spinning technique. The invention further relates to a polymer loaded with one or more bioactive agents, obtainable by said process and to the use thereof as a carrier for controlled drug release or as scaffold for tissue engineering.
    Type: Application
    Filed: October 28, 2003
    Publication date: May 6, 2004
    Applicant: Chienna B.V.
    Inventors: Jeroen Mattijs Bezemer, Clemens Antoni van Blitterswijk, Jan Feijen, Dirk Wybe Grijpma
  • Patent number: 6692790
    Abstract: The invention relates to a method for providing a proteinaceous coating on a medical implant, comprising the steps of: submersing the implant in a first aqueous solution comprising a protein and magnesium, calcium and phosphate ions through which a gaseous weak acid is passed; degassing the solution; allowing a coating to precipitate onto the implant; submersing the coated implant in a second solution to redissolve the magnesium, calcium and phosphate ions and to obtain the proteinaceous coating.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: February 17, 2004
    Assignee: Chienna B.V.
    Inventors: Yuelian Liu, Klaas de Groot, Pierre Jean F. Layrolle
  • Patent number: 6685957
    Abstract: A fibrous polymer implant loaded with one or more bioactive agents is prepared using a wet spinning technique. Preferably, an aqueous solution of bioactive agent is added to a solution of amphiphilic block copolymer containing hydrophilic blocks such as polyalkylene glycol and hydrophobic blocks such as an aromatic ester dissolved in a first solvent immiscible with water to form an emulsion. The emulsion is injected through a nozzle into a second solvent miscible with the first solvent in which the copolymer is essentially insoluble to form a solid copolymer fiber loaded with the bioactive agent. The fiber is shaped into an implant. Water content of the aqueous solution of bioactive agent affects rate of release of the bioactive agent in vivo. Bioactive agents include peptides, oligopeptides, polypeptides and proteins. The implant may be used as a carrier for controlled drug release or as a scaffold for tissue engineering.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: February 3, 2004
    Assignee: Chienna B.V.
    Inventors: Jeroen Mattijs Bezemer, Clemens Antoni van Blitterswijk, Jan Feijen, Dirk Wybe Grijpma