Patents Assigned to Chienna B.V.
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Publication number: 20070254103Abstract: The invention relates to a coating for medical devices. The coating comprises a specific copolymer of which the composition may be adjusted such as to achieve an excellent adhesion to a wide range of surfaces. The coating may further comprise an additive, such as a biologically active agent, which may be released in vivo in a controlled manner, as the degradability of the coating may also be adjusted to a predetermined rate. The invention further relates to a process for applying the coating to a surface and to a medical device comprising the coating.Type: ApplicationFiled: April 26, 2007Publication date: November 1, 2007Applicant: Chienna B.V.Inventors: Jerome Sohier, Jeroen Bezemer
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Patent number: 7226612Abstract: The invention relates to a coating for medical devices. The coating comprises a specific copolymer of which the composition may be adjusted such as to achieve an excellent adhesion to a wide range of surfaces. The coating may further comprise an additive, such as a biologically active agent, which may be released in vivo in a controlled manner, as the degradability of the coating may also be adjusted to a predetermined rate. The invention further relates to a process for applying the coating to a surface and to a medical device comprising the coating.Type: GrantFiled: September 25, 2003Date of Patent: June 5, 2007Assignee: Chienna B.V.Inventors: Jerome Sohier, Jeroen Mattijs Bezemer
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Publication number: 20060258835Abstract: The invention relates to a poly(ether ester) multiblock copolymer material based on a combination of a poly(alkylene glycol) component, a short chain diol, an aromatic dicarboxylic acid or derivative thereof and at least one type of non-aromatic dicarboxylic acid or derivative thereof. The invention further relates to a process for the preparation of the polymeric material, a medical device comprising said polymeric material and the use of the medical device for the preparation of a medicament for guided tissue regeneration, as a scaffold for engineering tissue in vitro, or as a matrix for controlled release of a (bio)active substance.Type: ApplicationFiled: March 23, 2006Publication date: November 16, 2006Applicant: Chienna B.V.Inventors: Jeroen Bezemer, Jorg Roosma, Riemke van Dijkhuizen-Radersma, Joost de Wijn
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Publication number: 20050101692Abstract: The invention relates to a coating for medical devices. The coating comprises a specific copolymer of which the composition may be adjusted such as to achieve an excellent adhesion to a wide range of surfaces. The coating may further comprise an additive, such as a biologically active agent, which may be released in vivo in a controlled manner, as the degradability of the coating may also be adjusted to a predetermined rate. The invention further relates to a process for applying the coating to a surface and to a medical device comprising the coating.Type: ApplicationFiled: September 25, 2003Publication date: May 12, 2005Applicant: Chienna B.V.Inventors: Jerome Sohier, Jeroen Bezemer
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Publication number: 20050063941Abstract: The invention relates to a poly(ether ester) multiblock copolymer material based on a combination of a poly(alkylene glycol) component, a short chain diol, an aromatic dicarboxylic acid or derivative thereof and at least one type of non-aromatic dicarboxylic acid or derivative thereof. The invention further relates to a process for the preparation of the polymeric material, a medical device comprising said polymeric material and the use of the medical device for the preparation of a medicament for guided tissue regeneration, as a scaffold for engineering tissue in vitro, or as a matrix for controlled release of a (bio)active substance.Type: ApplicationFiled: August 26, 2004Publication date: March 24, 2005Applicant: Chienna B.V.Inventors: Jeroen Bezemer, Jorg Roosma, Riemke van Dijkhuizen-Radersma, Joost de Wijn
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Patent number: 6835391Abstract: The invention relates to new biologically degradable aliphatic copolymers of the polyesteramide or polyesterurethane type. The invention further relates to a method for preparing the copolymers and to products which can be manufactured from the new copolymers.Type: GrantFiled: March 29, 2002Date of Patent: December 28, 2004Assignee: Chienna B.V.Inventors: Jeroen Mattijs Bezemer, Jan Feijen, Pieter Jelle Dijkstra
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Publication number: 20040086544Abstract: The invention relates to a process for loading a polymer with one or more bioactive agents, using a wet spinning technique. The invention further relates to a polymer loaded with one or more bioactive agents, obtainable by said process and to the use thereof as a carrier for controlled drug release or as scaffold for tissue engineering.Type: ApplicationFiled: October 28, 2003Publication date: May 6, 2004Applicant: Chienna B.V.Inventors: Jeroen Mattijs Bezemer, Clemens Antoni van Blitterswijk, Jan Feijen, Dirk Wybe Grijpma
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Patent number: 6692790Abstract: The invention relates to a method for providing a proteinaceous coating on a medical implant, comprising the steps of: submersing the implant in a first aqueous solution comprising a protein and magnesium, calcium and phosphate ions through which a gaseous weak acid is passed; degassing the solution; allowing a coating to precipitate onto the implant; submersing the coated implant in a second solution to redissolve the magnesium, calcium and phosphate ions and to obtain the proteinaceous coating.Type: GrantFiled: August 5, 2002Date of Patent: February 17, 2004Assignee: Chienna B.V.Inventors: Yuelian Liu, Klaas de Groot, Pierre Jean F. Layrolle
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Patent number: 6685957Abstract: A fibrous polymer implant loaded with one or more bioactive agents is prepared using a wet spinning technique. Preferably, an aqueous solution of bioactive agent is added to a solution of amphiphilic block copolymer containing hydrophilic blocks such as polyalkylene glycol and hydrophobic blocks such as an aromatic ester dissolved in a first solvent immiscible with water to form an emulsion. The emulsion is injected through a nozzle into a second solvent miscible with the first solvent in which the copolymer is essentially insoluble to form a solid copolymer fiber loaded with the bioactive agent. The fiber is shaped into an implant. Water content of the aqueous solution of bioactive agent affects rate of release of the bioactive agent in vivo. Bioactive agents include peptides, oligopeptides, polypeptides and proteins. The implant may be used as a carrier for controlled drug release or as a scaffold for tissue engineering.Type: GrantFiled: September 29, 2000Date of Patent: February 3, 2004Assignee: Chienna B.V.Inventors: Jeroen Mattijs Bezemer, Clemens Antoni van Blitterswijk, Jan Feijen, Dirk Wybe Grijpma