Abstract: Heterocyclic compounds and salts according to formula (I), which are pyrimidinone derivatives, described herein exhibit human neutrophil elastase inhibitory properties, and useful for treating diseases or conditions in which HNE is implicated.
Type:
Grant
Filed:
December 16, 2014
Date of Patent:
February 21, 2017
Assignee:
Chiese Farmaceutici S.p.A.
Inventors:
Lilian Alcaraz, Jonathan Mark Sutton, Elisabetta Armani, Carmelida Capaldi
Abstract: The invention relates to a method of treatment of left ventricular dysfunction, by administering to a subject suffering from left ventricular remodeling a therapeutically effective amount of 5,6-dihydroxy-2-methylaminotetralin or 5,6-diisobutyroyl-oxy-2-methyl-aminotetralin, or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
February 19, 2002
Date of Patent:
June 10, 2003
Assignee:
Chiese Farmaceutici S.p.A.
Inventors:
Stefano Bongrani, Roberta Razzetti, Maurizio Civelli, Alberto Umile, Paolo Chiesi