Abstract: An electronic module for an inhaler includes a printed circuit board and electronic components configured to detect at least a status and/or at least a working parameter of the inhaler when the electronic module is attached to the inhaler. A battery is permanently joined to the printed circuit board. A first terminal and a second terminal are electrically connectable one to the other through a main switch to close a circuit between the battery and the electronic components. In a rest configuration, the first and second terminals are electrically separated by the main switch. In a work configuration, the first terminal and the second terminal are electrically connected one to the other through the main switch.
Type:
Grant
Filed:
November 27, 2020
Date of Patent:
May 30, 2023
Assignee:
CHIESI FARMACEUTICI S.P.A.
Inventors:
Alan Tweedie, Colin Mitchell, Scott Lewis, Andrew T. Heidt, Robert Rudolf
Abstract: Stable aerosol solution formulations comprising glycopyrronium bromide are useful for administration to patients with COPD and other respiratory conditions.
Abstract: Methods of treating, reducing the incidence of, and/or preventing an ischemic event in a patient undergoing percutaneous coronary intervention (PCI), comprising administering to the patient a pharmaceutical composition comprising cangrelor. The method may further comprise administering an additional therapeutic agent to the patient, the additional therapeutic agent comprising bivalirudin or a P2Y12 inhibitor. Pharmaceutical compositions useful for treating, reducing the incidence of, and/or preventing an ischemic event in a patient undergoing PCI. The pharmaceutical compositions comprise cangrelor, and optionally bivalirudin. Methods of preparing a pharmaceutical composition for treating, reducing the incidence of, and/or preventing an ischemic event in a patient undergoing PCI, comprising admixing cangrelor with one or more pharmaceutically acceptable excipients. An ischemic event may include stent thrombosis, myocardial infarction, ischemia-driven revascularization, and mortality.
Type:
Grant
Filed:
June 26, 2019
Date of Patent:
April 25, 2023
Assignee:
CHIESI FARMACEUTICI S.P.A.
Inventors:
Clive Arthur Arculus-Meanwell, Simona Skerjanec, Jayne Prats
Abstract: Dry powder formulations for inhalation containing a combination of an anticholinergic, a long-acting beta2-adrenoceptor agonist, and a corticosteroid are useful for the prevention and/or treatment of an inflammatory and/or obstructive airways disease.
Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
Abstract: Stable aerosol solution formulations comprising glycopyrronium bromide are useful for administration to patients with COPD and other respiratory conditions.
Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are oxidazole derivatives, processes for preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
Type:
Grant
Filed:
December 12, 2018
Date of Patent:
February 14, 2023
Assignee:
Chiesi Farmaceutici S.p.A.
Inventors:
Alessandro Accetta, Fabio Rancati, Christine Edwards, Elizabeth Anne Skidmore
Abstract: The invention generally refers to a stainless steel can for use in a metered dose inhaler device, containing an aerosol formulation, comprising glycopyrronium bromide and formoterol, or a salt or a solvate thereof, optionally in combination with one or more additional active ingredient, endowed with a high stability.
Type:
Application
Filed:
December 2, 2019
Publication date:
December 15, 2022
Applicant:
CHIESI FARMACEUTICI S.P.A.
Inventors:
Enrico ZAMBELLI, Sauro BONELLI, Diego COPELLI, Massimiliano DAGLI ALBERI, Francesca USBERTI
Abstract: A device (100) for facilitating the positioning of a catheter for the administration of a liquid medicament to a spontaneously breathing patient. The method and system according to preferred embodiments of the present invention allows optimizing the dispensing said medicaments. In particular the system according to a preferred embodiment of the present invention allows the administration of an exogenous pulmonary surfactant to preterm patients.
Abstract: A method for reducing or maintaining platelet inhibition in a patient by administering cangrelor prior to an invasive procedure is described. The method of this invention can be used for patients in need of antiplatelet therapy or at risk of thrombosis. The method can further be used in patients who were previously treated with long-acting platelet inhibitors without increasing the risk of excessive bleeding.
Type:
Grant
Filed:
July 14, 2020
Date of Patent:
November 29, 2022
Assignee:
Chiesi Farmaceutici S.p.A.
Inventors:
Lisa Ruderman Chen, Simona Skerjanec, Dawn Bell, Jayne Prats, Meredith Todd
Abstract: The present invention relates to a process for the preparation of compounds endowed with phosphodiesterase (PDE4) inhibitory activity having formula (I). The invention also relates to the process for the isolation by crystallization of the compound (I) and to its use for the preparation of pharmaceutical compositions for inhalation in combination with suitable carriers or vehicles. The present invention also relates to solvates and crystal forms of a compound of formula (I). The synthesized product is suitable for use in pharmaceutical applications for instance in the treatment of respiratory diseases.
Abstract: The present invention relates to methods for lowering stroke damages and/or lowering blood pressure in a subject with a stroke in need thereof, comprising administering to the subject an effective amount of a pharmaceutical composition comprising a short acting dihydropyridine compound, preferably clevidipine or a pharmaceutically acceptable salt or ester thereof. Also provided are related medicaments, pharmaceutical compositions, and methods for preparing the medicaments.
Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
Abstract: An actuator for a pressurized metered dose inhaler providing a significant reduction in the non-respirable coarse fraction of the emitted aerosol medicament impacting in the oro-pharynx, with consequent less associated side effects and oral candidiasis in the patient, due to the fact that the mouthpiece portion has a central rounded opening of a well-defined width and distance from the nozzle aperture and also provided with a cylindrical recess, whose central axis is aligned with the central longitudinal axis of the mouthpiece portion and with the central longitudinal axis of the nozzle channel.
Abstract: Aerosol formulations comprising glycopyrronium bromide in combination with formoterol are useful for the prevention or treatment of chronic obstructive pulmonary disease. The formulation further comprises a HFA propellant, a co-solvent, and an amount of inorganic acid sufficient to stabilize both the glycopyrronium bromide and the formoterol components. Optionally the formulation may further comprise beclometasone dipropionate.
Abstract: The present invention relates to the use of agents, which are 1-phenyl-2-pyridinyl alkyl alcohol derivatives, for the prevention and/or treatment of cystic fibrosis in a subject, wherein the subject is characterized by at least one mutation in the gene encoding the CFTR protein, wherein the at least one mutation is causative for incorrect folding and/or processing of the CFTR protein. By the use of the compound according to the present invention, cystic fibrosis in the subject may be prevented or treated. The agent to be used according to the present invention has the capacity to restore the presence of the mutant CFTR protein at the cell surface, and thus act as CFTR correctors. The agent to be used according to the present invention may be administered to a subject in need thereof alone or in combination therapy with other agents, and is suitably administered by inhalation.
Abstract: System comprising a pre-fillable syringe with a syringe barrel and a syringe tip and a package suitable and intended for receiving the pre-fillable syringe, wherein the syringe tip is provided with a tip cap, wherein the system comprises a replacement cap for the pre-fillable syringe, wherein the package is suitable and intended for receiving the replacement cap.
Type:
Grant
Filed:
March 11, 2020
Date of Patent:
June 28, 2022
Assignee:
Chiesi Farmaceutici S.p.A.
Inventors:
Jurgen Pfrang, Andreas Gorshofer, Marta Lombardini
Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
Abstract: The invention relates to compounds of formula (I) inhibiting phosphoinositide 3-kinases (PI3K), to pharmaceutical compositions comprising them and therapeutic use thereof in the treatment of disorders associated with PI3K enzymes.
Type:
Application
Filed:
March 24, 2020
Publication date:
June 9, 2022
Applicant:
CHIESI FARMACEUTICI S.P.A.
Inventors:
Matteo BIAGETTI, Paolo RONCHI, Claudio FIORELLI, Paolo BRUNO
Abstract: System comprising a pre-fillable syringe with a syringe barrel and a syringe tip and a package suitable and intended for receiving the pre-fillable syringe, wherein the syringe tip is provided with a tip cap, wherein the system comprises a replacement cap for the pre-fillable syringe, wherein the package is suitable and intended for receiving the replacement cap.
Type:
Grant
Filed:
March 15, 2019
Date of Patent:
June 7, 2022
Assignee:
Chiesi Farmaceutici S.p.A.
Inventors:
Jurgen Pfrang, Andreas Gorshofer, Marta Lombardini