Abstract: Disclosed herein are methods that employ the use of one or more biomarkers for the treatment of SARS-CoV-2 infected individuals (COVID-19 patients). The methods may employ detection and measurement of one or more cytokines, the measurement of which may be used to treat COVID-19 patients with one or more immunomodulatory therapies.

Abstract: A method for k-space registration is provided. The method of k-space registration includes receiving a first partial k-space dataset for an object and a second partial k-space dataset for the object, selecting the first partial k-space dataset as a reference, selecting feature for estimating a transformation matrix for transforming k-space data, estimating a transformation matrix based on the feature of entire or part of the first partial k-space dataset and the feature of the second partial k-space dataset corresponding to the entire or part of the first partial k-space dataset, correcting the second partial k-space dataset based on the transformation matrix, and obtaining the corrected second partial k-space dataset. The present method is further used for partial Fourier reconstruction.

Abstract: Apparatus and methods to add heat capacity to a cryogenic apparatus such as a superconducting magnet are provided. A body of liquid cryogen having a relatively high heat capacity is stored at cryogenic temperatures in a low temperature vessel that is thermally linked to a cold mass within the cryogenic apparatus. The low temperature vessel is connected to a manifold system located on the exterior of the cryogenic apparatus. The manifold is further connected to a room temperature vessel so that gas is allowed to freely move between the low temperature and room temperature vessels.

Abstract: Apparatus and methods to create and/or enhance thermal gradients in a body of cryogenic liquid contained in a vessel that is actively cooled by a cryocooler is provided. With such apparatus and/or methods temperature in one part of the body of liquid can be made lower than the temperature in another part of the body of liquid. Thus, the apparatus and/or methods enables cryogenic operation of a device at a temperature that is below that of the boiling point of the cryogenic liquid while simultaneously allowing the liquid to be at a pressure greater than atmospheric pressure to obviate the risk of air entering the cryogenic space. These apparatus and/or methods may find use in cryogenic systems used for magnetic resonance imaging, cyclotrons for radioisotope generation, cyclotrons for radiation therapy, high-energy particle accelerators, magnet systems for crystal growth and the like.

Abstract: Disclosed are compositions and methods of treating a neurodegenerative disease in an individual. The methods disclose administration of an Integrin ?4?1, Very Late Antigen-4 positive neural precursor cell (“VLA4+ NPC”) transfected with a lentivirus overexpressing wild type GCase to an individual having a neurodegenerative disorder. The neurodegenerative disease may include lipid storage diseases, for example Gaucher disease, Parkinson's disease (PD), Dementia with Lewy bodies.

Abstract: Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I)). Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as cancer or blood disorders). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein.

Abstract: A frequency encoded source imaging system includes an EEG or MEG sensor array and a processing system for analyzing the signals from the sensor array in at least two different frequency bands, where the analysis is localized with respect to a three-dimensional grid corresponding to the portion of the human body.

Abstract: The present disclosure describes a computational model of a learning network. The computational model may be implemented as instructions stored on a non-transitory memory that may be executed by a processor on a local machine or as part of a cloud-based architecture employing one or more multi-thread processors enabling different users to utilize the tool to enter data and visualize results simultaneously from different locations. The computational model may accept inputs corresponding to characteristics of a patient agent and characteristics of a clinician agent. The computational model may simulate how the patient agent and the clinician agent interact with respect to a treatment selection and efficacy and may additionally and iteratively simulate further interactions between the patient agent and the clinician agent. The computational model may record how the interactions between the patient agent and the clinician agent change patient agent outcomes over time.

Abstract: Disclosed are methods of diagnosing and treating a subject with active or inactive eosinophilic esophagitis (EoE). The methods may include the steps of detecting whether a level of eosinophil lineage-committed progenitor (EoP) is elevated in a blood sample obtained from a subject, diagnosing the subject with active EoE when an EoP level in the sample is elevated above a pre-determined cut-off value and diagnosing the subject with inactive EoE when the EoP level in the sample is below a pre-determined cut-off value; and treating the subject diagnosed with active EoE. Kits related to same are also disclosed.

Abstract: A laryngoscope may include a handle and a blade. The handle and blade may be a single piece and the handle may include undulating contours configured to ergonomically fit the user's hand. The blade may have a first end proximate the handle and a second end oppositely disposed from the first end. The blade end may include an anatomically contoured or undulating profile at the second end configured to correspond with an associate epiglottis and tongue of a patient. The laryngoscope may be disposable and configured for a single use. The blade may have an unilluminated state and an illuminated state.

Abstract: Disclosed are compositions and methods for slowing, preventing, or reversing platelet damage, particularly as may occur during blood banking or during refrigeration of platelets. The composition may include one or more of a RAC inhibitor, a CDC42 inhibitor, a RHOA inhibitor, or a combination thereof. The compositions may further include a pharmaceutically acceptable carrier.

Abstract: A frequency encoded source imaging system includes an EEG or MEG sensor array and a processing system for analyzing the signals from the sensor array in at least two different frequency bands, where the analysis is localized with respect to a three-dimensional grid corresponding to the portion of the human body. Alternately, a frequency encoded source imaging system includes an EEG or MEG sensor array and a processing system for analyzing the signals from the sensor array in a high-definition frequency band comprising frequencies greater than 70 Hz, where the analysis is localized with respect to a three-dimensional grid corresponding to the portion of the human body.

Abstract: A method for the treatment or the prevention of a kidney disorder is disclosed. The method involves administering an effective concentration of pregnenolone sulfate to a subject to increase cytoplasmic Ca2+ in kidney cells.

Abstract: Disclosed herein are virus-like particle (VLP)-based bivalent vaccine compositions. The compositions may comprise a spherical retroviral Group—specific Antigen (“Gag”) protein core and at least two Ebola glycoproteins. The at least two Ebola glycoproteins may be located at the exterior surface of the spherical Gag protein core, such that the VLP-based vaccine presents at least two Ebola glycoprotein antigens. In one aspect, the at least two Ebola glycoproteins are a Zaire (EBOV) glycoprotein, and a Sudan (SUDV) glycoprotein.

Abstract: A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.

Abstract: A patient table adapted for use in association with an MR scanner for neonatal infants is provided. The patient table has an extendable patient bed attached to and extendable from the patient table. The patient bed may be at least partially inserted into an MR scanner without requiring the patient table to enter the MR scanner. A transport mechanism is on the underside of the patient table so that it may be readily moved over the floor on which it rests. The patient table includes a latching mechanism that may operate to releasably attach the patient table to a patient table docking assembly. The docking assembly is operative to selectively move the patient table towards, into and away from the MR scanner.

Abstract: Methods and compositions disclosed herein generally relate to methods of identifying, validating, and measuring clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses for blood, vascular, cardiac, and respiratory tract dysfunction, particularly as those responses relate to septic shock in pediatric patients. In particular, the invention relates to identifying two or more biomarkers associated with septic shock in pediatric patients, obtaining a sample from a pediatric patient having at least one indication of septic shock, then quantifying from the sample an amount of two or more of said biomarkers, wherein the level of said biomarker correlates with a predicted outcome.

Abstract: An image guided autonomous needle insertion device including a delivery system, a path planner, an image processor, and a human machine interface. The system also includes an ultrasound probe in communication with a frame grabber, a percutaneous insertion device, and at least a first actuator for moving the percutaneous insertion device within a first degree of freedom and a second actuator for moving the percutaneous insertion device within a second degree of freedom. Each actuator has a corresponding position sensor for detecting its location with respect to a target. The system can further comprise an image processor for removing noise and segmenting the ultrasound images to highlight potential targets.

Abstract: Some embodiments of the invention include polypeptides comprising a myomerger polypeptide or an extracellular myomerger polypeptide. Other embodiments of the invention include nucleic acid molecules encoding polypeptides comprising a myomerger polypeptide or an extracellular myomerger polypeptide. Other embodiments of the invention include vectors comprising the nucleic acid molecule. Yet other embodiments of the invention include methods of using a myomerger polypeptide or an extracellular myomerger polypeptide. Additional embodiments of the invention are also discussed herein.

Abstract: A birdcage coil for a magnetic resonance imaging (MRI) system, the birdcage coil includes: a relatively planar birdcage coil section, including a pair of relatively planar ring portions and a plurality of conductive, elongated rungs extending between the pair of relatively planar ring portions; and a relatively domed birdcage coil section, including a pair of relatively domed ring portions and a plurality of conductive, elongated rungs extending between the pair of relatively domed ring portions. The relatively domed birdcage coil section is releasably coupled to the relatively planar birdcage coil section. In an embodiment, at least two sets of the relatively planar and domed birdcage coil sections are provided, where each of the at least two sets is configured to a different MRI application.