Abstract: Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand.
Type:
Application
Filed:
September 28, 2012
Publication date:
August 1, 2013
Applicant:
Children's Hospital and Regional Medical Center
Inventor:
Children's Hospital and Regional Medical Center
Abstract: Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing the involving a PD1 ligand.
Type:
Grant
Filed:
October 1, 2008
Date of Patent:
November 22, 2011
Assignee:
The Children's Hospital and Regional Medical Center
Abstract: According to particular exemplary aspects, DNA target site binding and cleavage properties of native, variant or modified homing endonucleases (HE) (e.g., LAGLIDAG (LHE), HNH, His-Cys Box, GIY-YIG, I-SspI-type, and fusions, muteins or variants thereof) in solution are recapitulated on the cell surface (e.g., as assessed by flow cytometric analysis) to provide for novel cells expressing one or more cell surface HEs (e.g., expressing one or more HE binding and/or cleavage specificities), novel cell libraries, and high-throughput methods for assessing target site binding, target site cleavage. The rapid analysis of HE and LHE-DNA interactions on the cell surface with concurrent sorting options provides for high-throughput library screening affording rapid identification, analysis and isolation of novel HEs or LHEs having novel sequence specificities.
Type:
Application
Filed:
March 27, 2007
Publication date:
June 25, 2009
Applicant:
CHILDREN'S HOSPITAL & REGIONAL MEDICAL CENTER
Abstract: The present invention relates generally to the field of microbiology and food sciences. More particularly, the inventor has discovered several polynucleotide sequences encoding the gnd gene and corresponding 6-phosphogluconate dehydrogenase (6-PGD) proteins from different strains of Escherichia Coli and polymorphic sequences therein. Novel biotechnological tools, diagnostics, and food screening techniques are provided.
Type:
Application
Filed:
April 12, 2007
Publication date:
May 1, 2008
Applicant:
Children's Hospital and Regional Medical Center