Patents Assigned to Children's Hospital Boston
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Publication number: 20140302043Abstract: The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.Type: ApplicationFiled: February 3, 2014Publication date: October 9, 2014Applicants: DUKE UNIVERSITY, CHILDREN'S HOSPITAL BOSTONInventors: James Whittle, Stephen C. Harrison, Barton F. Haynes, Hua-Xin Liao, M. Anthomy Moody, Thomas B. Kepler, Aaron G. Schmidt
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Patent number: 8758283Abstract: The present invention is a simple, adaptable orthotic device that can correct and/or prevent deformational posterior plagiocephaly, especially if used before the infant is 4 months of age. The manufactured article provides an anatomically correcting, adjustable, concave-shaped resting surface for an infant's head in a manner that effectively eliminates uneven pressure on the infant's occiput. The orthotic device has a modular design which permits easy adjustments of the devices' head cavity to accommodate differences in individual infant head size and shape, thereby providing the infant's head with a custom fit. Also, as the infant continues to grow in size, the adjustable head cavity and torso recess features of the orthotic device allow the contoured spatial volume and dimensions of the molded supporting surfaces to expand as the infant's calvaria grow; and thereby facilitate a progressive, normalization and rounding of the infant's occiput.Type: GrantFiled: March 28, 2012Date of Patent: June 24, 2014Assignees: Boston Brace, Children's Hospital BostonInventors: Gary F. Rogers, James R. Miller
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Patent number: 8642333Abstract: The present invention provides a vehicle for delivering various chemicals, compositions and proteins to stem cells and embryoid bodies. The vehicle may be biocompatible and biodegradable polymer microparticles. Typically the particles will contain at least a growth factor for delivery to the embryoid bodies, and generally the growth factor induces differentiation of the cells in the embryoid body along a specific lineage. The present invention also provides methods for directing differentiation of the cells in the embryoid body.Type: GrantFiled: February 4, 2009Date of Patent: February 4, 2014Assignees: Massachusetts Institute of Technology, Children's Hospital BostonInventors: Lino da Silva Ferreira, Daniel Kohane, Robert Langer
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Publication number: 20130289520Abstract: The present invention provides methods and compositions for highly precise spatial and temporal control over cytosolic delivery of compounds, in particular, those compounds that would otherwise be cell-impermeable. Among other things, the present invention provides a composition for targeted drug delivery comprising a nanoparticle, a targeting moiety specific for a cell type of interest, a light-activated drug delivery system, wherein the nanoparticles are associated with the targeting moiety and the light-activated drug delivery system.Type: ApplicationFiled: April 22, 2011Publication date: October 31, 2013Applicants: CHILDREN'S HOSPITAL BOSTON, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Sebastien Febvay, Davide Maurizio Marini, David E. Clapham
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Patent number: 8414607Abstract: The present invention relates generally to the field of micro-scale or millimeter scale devices and to the use of multi-layer multi-material electrochemical fabrication methods for producing such devices with particular embodiments relate to shredding devices and more particularly to shredding devices for use in medical applications. In some embodiments, tissue removal devices include tissue anchoring projections, improved blade configurations, and/or shields or shrouds around the cutting blades to inhibit outflow of tissue that has been brought into the device.Type: GrantFiled: June 24, 2009Date of Patent: April 9, 2013Assignees: Microfabrica Inc., Trustees of Boston University, Children's Hospital BostonInventors: Michael S. Lockard, Uri Frodis, Adam L. Cohen, Richard T. Chen, Pierre E. Dupont, Pedro J. Del Nido, Nikolay V. Vasilyev
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Patent number: 8329175Abstract: The invention features methods and compositions for treating and preventing angiogenic disorders and endothelial cells disorders using HspA12B antagonist and HspA12B agonist compounds, respectively.Type: GrantFiled: August 18, 2006Date of Patent: December 11, 2012Assignees: Beth Israel Deaconess Medical Center, Inc., Children's Hospital BostonInventors: Vikas P. Sukhatme, Leonard I. Zon, Jenna Galloway
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Publication number: 20120251457Abstract: Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7.Type: ApplicationFiled: March 28, 2012Publication date: October 4, 2012Applicants: CHILDREN'S HOSPITAL BOSTON, JOSLIN DIABETES CENTER, INC.Inventors: C. Ronald Kahn, Yu-Hua Tseng, Atul Butte
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Patent number: 8186354Abstract: The present invention is a simple, adaptable orthotic device that can correct and/or prevent deformational posterior plagiocephaly, especially if used before the infant is 4 months of age. The manufactured article provides an anatomically correcting, adjustable, concave-shaped resting surface for an infant's head in a manner that effectively eliminates uneven pressure on the infant's occiput. The orthotic device has a modular design which permits easy adjustments of the devices' head cavity to accommodate differences in individual infant head size and shape, thereby providing the infant's head with a custom fit. Also, as the infant continues to grow in size, the adjustable head cavity and torso recess features of the orthotic device allow the contoured spatial volume and dimensions of the molded supporting surfaces to expand as the infant's calvaria grow; and thereby facilitate a progressive, normalization and rounding of the infant's occiput.Type: GrantFiled: August 10, 2010Date of Patent: May 29, 2012Assignees: Boston Brace, Children's Hospital BostonInventors: Gary F. Rogers, James R. Miller
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Patent number: 8178492Abstract: Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7.Type: GrantFiled: July 14, 2009Date of Patent: May 15, 2012Assignees: Joslin Diabetes Center, Inc., Children's Hospital BostonInventors: C. Ronald Kahn, Yu-Hua Tseng, Atul Butte
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Publication number: 20110117049Abstract: Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7.Type: ApplicationFiled: July 14, 2009Publication date: May 19, 2011Applicants: Joslin Diabetes Center, Inc., Children's Hospital BostonInventors: C. Ronald Kahn, Yu-Hua Tseng, Atul Butte
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Patent number: 7810501Abstract: The present invention is a simple, adaptable orthotic device that can correct and/or prevent deformational posterior plagiocephaly, especially if used before the infant is 4 months of age. The manufactured article provides an anatomically correcting, adjustable, concave-shaped resting surface for an infant's head in a manner that effectively eliminates uneven pressure on the infant's occiput. The orthotic device has a module design which permits easy adjustments of the devices' head cavity to accommodate differences in individual infant head size and shape, thereby providing the infant's head with a custom fit. Also, as the infant continues to grow in size, the adjustable head cavity and torso recess features of the orthotic device allow the contoured spatial volume and dimensions of the molded supporting surfaces to expand as the infant's calvaria grow; and thereby facilitate a progressive, normalization and rounding of the infant's occiput.Type: GrantFiled: September 24, 2007Date of Patent: October 12, 2010Assignees: Boston Brace, Children's Hospital BostonInventors: Gary F Rogers, James R Miller
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Publication number: 20090304641Abstract: In certain embodiments, the disclosure relates to compositions and methods relating to a translation-based gene regulation system that functions in mammalian cells. In certain specific embodiments, the disclosure relates to methods of regulating gene expression via modulating translational termination.Type: ApplicationFiled: October 17, 2006Publication date: December 10, 2009Applicant: CHILDREN'S HOSPITAL BOSTONInventors: Richard Mulligan, George J. Murphy
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Publication number: 20090214572Abstract: The invention features methods and compositions for treating and preventing angiogenic disorders and endothelial cells disorders using HspA12B antagonist and HspA12B agonist compounds, respectively.Type: ApplicationFiled: August 18, 2006Publication date: August 27, 2009Applicants: Beth Israel Deaconess Medical Center, Children's Hospital BostonInventors: Vikas P. Sukhatme, Leonard I. Zon, Jenna Galloway
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Patent number: 7576052Abstract: Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7.Type: GrantFiled: October 18, 2004Date of Patent: August 18, 2009Assignees: Joslin Diabetes Center, Inc., Children's Hospital BostonInventors: C. Ronald Kahn, Yu-Hua Tseng, Atul Butte
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Patent number: 7225554Abstract: The invention relates to apparatus and methods for measuring a human head. The apparatus disclosed herein involve the use of linear rulers, or rotating contacting members, coupled to a support member. The apparatus disclosed herein can be positioned on a human head, using the methods disclosed herein, to determine the outer contour of the head. Such a measurement can aid in the diagnosis and monitoring of various abnormalities of the human head, including plagiocephaly.Type: GrantFiled: February 28, 2005Date of Patent: June 5, 2007Assignee: Children's Hospital BostonInventor: Joseph R. Madsen
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Publication number: 20060042013Abstract: The present invention relates to a head support device for the treating and prevention of plagiocephaly in infants. The device removes pressure from a desired area of an infant's head.Type: ApplicationFiled: August 31, 2004Publication date: March 2, 2006Applicant: Children's Hospital BostonInventor: Joseph Madsen
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Publication number: 20050223580Abstract: The invention relates to apparatus and methods for measuring a human head. The apparatus disclosed herein involve the use of linear rulers, or rotating contacting members, coupled to a support member. The apparatus disclosed herein can be positioned on a human head, using the methods disclosed herein, to determine the outer contour of the head. Such a measurement can aid in the diagnosis and monitoring of various abnormalities of the human head, including plagiocephaly.Type: ApplicationFiled: February 28, 2005Publication date: October 13, 2005Applicant: Children's Hospital BostonInventor: Joseph Madsen
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Publication number: 20050187154Abstract: Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7.Type: ApplicationFiled: October 18, 2004Publication date: August 25, 2005Applicants: Joslin Diabetes Center, Inc., Children's Hospital BostonInventors: C. Ronald Kahn, Yu-Hua Tseng, Atul Butte