Abstract: The present invention provides dietary formulations comprising polyunsaturated fatty acids and vitamin E. The present invention further provides methods of treating various conditions, generally involving administering to an individual in need thereof an effective amount of a subject dietary formulation.
Type:
Grant
Filed:
February 19, 2008
Date of Patent:
May 28, 2019
Assignee:
CHILDREN'S HOSPITAL OF OAKLAND RESEARCH INSTITUTE
Abstract: Disclosed is a method of determining KIR genotypes for one or more individuals in parallel, the method comprising: for each individual, amplifying the polymorphic exon sequences of the KIR genes, pooling the KIR amplicons, performing emulsion PCR followed by pyrosequencing in parallel to determine all the amplicon sequences present in the individual to determine which KIR alleles are present in the individual.
Type:
Application
Filed:
February 3, 2015
Publication date:
July 2, 2015
Applicants:
Roche Molecular Systems, Inc., Children's Hospital Oakland Research Institute
Inventors:
Martha Ladner, Elizabeth Trachtenberg, Lloyd Gordon Bentley, Damian Goodridge, Henry A. Erlich
Abstract: The present invention provides nutritional compositions (for example, sensorially acceptable nutritional compositions) that comprise a fruit component, a fiber component, and a micronutrient component. Also provided are methods of making and using the nutritional compositions.
Type:
Application
Filed:
September 30, 2011
Publication date:
October 16, 2014
Applicants:
CHILDREN'S HOSPITAL OAKLAND RESEARCH INSTITUTE
Inventors:
Bruce Ames, Mark Shigenaga, Michele M. Snyder, Joyce McCann, Tara H. McHugh, Danald A. Olson
Abstract: Compositions and methods for therapy of cystic fibrosis, asthma, and other conditions characterized by defective chloride transport are provided. The compositions comprise one or more compounds such as flavones and/or isoflavones, ascorbate and/or derivatives thereof capable of stimulating chloride transport in epithelial tissues. Therapeutic methods involve the administration (e.g., orally or via inhalation) of such compositions to a patient afflicted with cystic fibrosis, asthma, and/or another condition responsive to stimulation of chloride transport.
Abstract: Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.
Type:
Application
Filed:
January 17, 2002
Publication date:
September 18, 2003
Applicant:
Children's Hospital Oakland Research Institute
Abstract: Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.
Type:
Grant
Filed:
July 19, 1999
Date of Patent:
May 27, 2003
Assignee:
Children's Hospital Oakland Research Institute
Abstract: Compositions and methods for therapy of cystic fibrosis and other conditions are provided. The compositions comprise one or more compounds such as flavones and/or isoflavones capable of stimulating chloride transport in epithelial tissues. Therapeutic methods involve the administration (e.g., orally or via inhalation) of such compositions to a patient afflicted with cystic fibrosis and/or another condition responsive to stimulation of chloride transport.
Abstract: Compositions and methods for therapy of cystic fibrosis and other conditions are provided. The compositions comprise one or more compounds such as flavones and/or isoflavones capable of stimulating chloride transport in epithelial tissues. Therapeutic methods involve the administration (e.g., orally or via inhalation) of such compositions to a patient afflicted with cystic fibrosis and/or another condition responsive to stimulation of chloride transport.
Type:
Grant
Filed:
October 16, 1998
Date of Patent:
December 11, 2001
Assignee:
Children's Hospital Oakland Research Institute