Patents Assigned to Children's Medical Center Corporation
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Publication number: 20240358502Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.Type: ApplicationFiled: May 6, 2024Publication date: October 31, 2024Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College, Massachusetts Institute of TechnologyInventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Elazer R. Edelman, Peter E. Hammer, Christopher Payne
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Patent number: 12129491Abstract: Described herein are methods and compositions relating to the provision and/or differentiation of certain fully differentiated lung cell types, including surfactant producing cells (e.g. club secretory cells), mucus producing (Goblet) cells, mucus-producing goblet like cells, and beating ciliated cells. In some embodiments, one or more of the differentiated lung cell types is present in an organoid. Differentiation of these lung cell types can be induced by contacting lung stem and/or progenitor cells with one or more inhibitors of H3K9me1/2 methyltransferase, e.g., an inhibitor of G9a and/or G1p (EMHT2 and/or EHMT1).Type: GrantFiled: June 8, 2017Date of Patent: October 29, 2024Assignee: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Carla F. Kim, Samuel P. Rowbotham, Joo-Hyeon Lee
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Publication number: 20240353517Abstract: Described herein are techniques to estimate motion of a subject during a magnetic resonance image (MRI) scan. The estimation may be based on one or more slices acquired during the MRI scan, permitting automated estimation of motion of the subject during the MRI scan. Some such techniques may be performed during the MRI scan, before the completion of the MRI scan, or after the MRI scan before or after magnetic resonance data (MR data) resulting from the MRI scan has been processed to generate an image from the MR data.Type: ApplicationFiled: August 19, 2022Publication date: October 24, 2024Applicant: Children's Medical Center CorporationInventors: Yao Sui, Onur Afacan, Ali Gholipour-Baboli, Simon K. Warfield
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Publication number: 20240352154Abstract: Described herein are compositions (e.g. cells and transgenic animals) and methods relating to engineered Ig loci that permit expression of particular antibodies or antibody segments while still permitting recombination and/or maturation process for antibody optimization.Type: ApplicationFiled: March 18, 2024Publication date: October 24, 2024Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Frederick W. ALT, Suvi JAIN, Zhaoqing BA, Ming TIAN
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Patent number: 12123869Abstract: Provided herein, inter alia, are improved methods for detecting analytes, including proteins and nucleic acids. In some instances, the analytes are detected in complex matrices such as serum.Type: GrantFiled: March 23, 2017Date of Patent: October 22, 2024Assignee: Children's Medical Center CorporationInventors: Clinton H. Hansen, Wesley Philip Wong, Darren Yang, Andrew Ward
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Patent number: 12121215Abstract: A device for performing surgical procedures, such as intracardiac procedures or neurosurgical procedures, includes a solid optical window formed of a transparent, compliant material, wherein the solid optical window includes a proximal side and a distal side, wherein a distal face of the solid optical window is configured to approach tissue during a surgical procedure; an imaging system embedded into the solid optical window and positioned to obtain an image through at least a portion of the distal face of the solid optical window; and a tool channel formed through the solid optical window from the proximal side to the distal side of the solid optical window, wherein the tool channel is configured to receive a tool for performing the surgical procedure.Type: GrantFiled: September 29, 2022Date of Patent: October 22, 2024Assignee: Children's Medical Center CorporationInventor: Pierre Dupont
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Publication number: 20240342173Abstract: The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.Type: ApplicationFiled: February 13, 2024Publication date: October 17, 2024Applicants: THE CHILDREN'S MEDICAL CENTER CORPORATION, DANA-FARBER CANCER INSTITUTE, INC.Inventors: James BRADNER, Jun QI, Dennis BUCKLEY, Leonard I. ZON, Elizabeth MACARI
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Patent number: 12114910Abstract: An electrocautery device with a retractable suction tube is described. The electrocautery device includes a suction tube assembly that can move between an extended or retracted position using vacuum force generated by a suction source. In some embodiments, the suction tube assembly automatically locks into the extended position when extended such that axial force cannot cause the suction tube assembly to retract. The device may be suitable for use in laparoscopic procedures. The suction tube may be coaxially aligned with the electrocautery tip.Type: GrantFiled: May 20, 2019Date of Patent: October 15, 2024Assignee: Children's Medical Center CorporationInventors: Heung Bae Kim, Gabriel J. Ramos-Gonzalez, Alexander Yang
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Patent number: 12117448Abstract: The invention relates to isolated peptides and chimeric polypeptides derived from Saposin A that have anti-angiogenic activity. These peptides are small, consisting essentially of at least 10 consecutive amino acid residues from the 31st-50th amino acid residue of Saposin A. The invention also relates to the use of these isolated peptides and chimeric polypeptides in compositions for the treatment, prevention, and inhibition of angiogenesis-related diseases and disorders such as cancer and cancer metastasis.Type: GrantFiled: May 5, 2020Date of Patent: October 15, 2024Assignee: Children's Medical Center CorporationInventor: Randolph Watnick
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Patent number: 12110553Abstract: This document features method related to variants in the Inverted Formin 2 (INF2) gene that are associated with susceptibility to focal segmental glomerulosclerosis (FSGS). For example, methods of using such variants for risk assessment and for diagnosing and optimizing treatment of FSGS are provided.Type: GrantFiled: December 7, 2020Date of Patent: October 8, 2024Assignees: The Brigham and Women's Hospital, Inc., Children's Medical Center CorporationInventors: Martin Pollak, Elizabeth J. Brown, Johannes Schlondorff
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Patent number: 12102692Abstract: Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells.Type: GrantFiled: October 5, 2021Date of Patent: October 1, 2024Assignees: Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute, Children's Medical Center CorporationInventors: Konstantina Stankovic, Luk H. Vandenberghe, Jeffrey Holt, Gwenaelle Geleoc
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Publication number: 20240318235Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.Type: ApplicationFiled: June 11, 2024Publication date: September 26, 2024Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human ServicesInventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
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Targeting BCL11A distal regulatory elements with a CAS9-CAS9 fusion for fetal hemoglobin reinduction
Patent number: 12098363Abstract: Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.Type: GrantFiled: July 20, 2018Date of Patent: September 24, 2024Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION, UNIVERSITY OF MASSACHUSETTSInventors: Daniel E. Bauer, Scot Wolfe, Mehmet Fatih Bolukbasi, Benjamin Roscoe, Pengpeng Liu, Kevin Luk, Yuxuan Wu, Jing Zeng -
Patent number: 12098169Abstract: Provided herein is a novel homolog of Clostridial botulinum neurotoxin (BoNT) identified in the bacterial species Enterococcus faecium (BoNT/EN). BoNT/EN variants and chimeric toxins comprising domains from BoNT/EN and other BoNTs are also provided. Further provided herein are methods of producing BoNT/EN and its use, e.g., in therapeutic applications.Type: GrantFiled: September 28, 2018Date of Patent: September 24, 2024Assignee: Children's Medical Center CorporationInventors: Min Dong, Paul Stenmark, Sicai Zhang, Andrew Doxey
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Patent number: 12097174Abstract: Disclosed herein are agents that enhance muscle stem cell engraftment, as well as methods and compositions using the same.Type: GrantFiled: December 26, 2022Date of Patent: September 24, 2024Assignees: President and Fellows of Harvard College, The Children's Medical Center CorporationInventors: Sahar Tavakoli, Amy J. Wagers, Leonard Zon
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Patent number: 12097307Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.Type: GrantFiled: July 15, 2021Date of Patent: September 24, 2024Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Arturo Vegas, Joshua C. Doloff, Omid Veiseh, Minglin Ma, Robert S. Langer, Daniel G. Anderson
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Patent number: 12097172Abstract: Embodiments herein disclose methods relating to diabetic nephropathy (DN); methods for preventing the onset and also for preventing the progressing of DN, as well as the treatment of DN in diabetic subjects comprising administering reparixin and/or ladarixin which are inhibitors of CXCL8 receptor CXCR1 and CXCR2 activation.Type: GrantFiled: February 24, 2022Date of Patent: September 24, 2024Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION, DOMPE FARMACEUTICI S.P.A.Inventors: Paolo Fiorina, Roberto Bassi, Andrea Vergani, Marcello Allegretti
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Patent number: 12091651Abstract: An automated isolation device for isolation of mitochondria includes an incubation station including a holder for a viable mitochondria solution; and a cooling system, controlled by a processor of the device, for cooling the holder. The device includes a processor-controlled transfer system for transferring solution from the holder to a filtration station; and the filtration station, including a series of filters. The device includes a processor-controlled spectrometry station including a spectrometer positioned to illuminate a cuvette fluidically coupled to an output of the filtration station; and a detector coupled to the processor and positioned on a side of the cuvette opposite the spectrometer. The device includes a processor-controlled transfer system for transferring solution from the spectrometry station to a centrifuge. The centrifuge is processor-controlled and configured to centrifuge the filtrate to separate viable mitochondria from a supernatant.Type: GrantFiled: May 8, 2019Date of Patent: September 17, 2024Assignee: Children's Medical Center CorporationInventors: James D. McCully, Douglas B. Cowan, Pedro J. Del Nido, Thomas Duignan
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Publication number: 20240299391Abstract: The present invention relates generally to methods for treatment of ribosomal disorders and ribosomopathy, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to methods for the use of a small-molecule autophagy modulator for treatment of ribosomal disorders and ribosomopathy. The invention also relates to small molecule drug discovery and methods of screening compositions to determine their effectiveness for treatment of ribosomal disorders and ribosomopathies.Type: ApplicationFiled: January 26, 2024Publication date: September 12, 2024Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Sergei DOULATOV, George Q. DALEY
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Patent number: 12083173Abstract: The present application is generally directed to novel pneumococcal polypeptide antigens and nucleic acids encoding such antigens, and immunogenic compositions comprising such antigens for treating and preventing pneumococcal infection. The present invention further provides method of using the antigens to elicits an immune response (e.g., IL-17A response, a T cell-mediated and/or B-cell-mediated immune responses). The present invention also provides methods of prophylaxis and/or treatment of pneumococcal-mediated diseases, such as sepsis, comprising administering an immunogenic composition including one or more of a combination of pneumococcal antigens or functional fragments thereof as disclosed herein. In some embodiments, one or more pneumococcal antigens can be present in a polysaccharide conjugate. The compositions induce an anti-pneumococcus immune response when administered to a mammal.Type: GrantFiled: June 7, 2022Date of Patent: September 10, 2024Assignee: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Richard Malley, Yingjie Lu, Fan Zhang