Patents Assigned to Children's Medical Center Corporation
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Publication number: 20250145677Abstract: Provided herein are methods and compositions comprising or using mutant semaphorin polypeptides.Type: ApplicationFiled: July 30, 2024Publication date: May 8, 2025Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATIONInventors: David M. BRISCOE, Diane BIELENBERG, Johannes WEDEL
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Publication number: 20250144228Abstract: Provided herein are conjugate molecules comprising an antibody or antibody fragment capable of binding polyclonal immnunoglobulins within a subject. Such conjugates are useful for recruiting immune cells of the subject to one or more cell types that are targeted by the conjugate. Also provided herein are compositions comprising the conjugates, including pharmaceutical compositions that may be administered to a subject, for such a purpose as to treat or prevent a disease.Type: ApplicationFiled: January 19, 2023Publication date: May 8, 2025Applicant: The Children's Medical Center CorporationInventors: Hidde L. Ploegh, Xin Liu, Novalia Pishesha, Elisha Verhaar
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Patent number: 12291742Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TEM3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.Type: GrantFiled: February 27, 2024Date of Patent: May 6, 2025Assignees: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human ServicesInventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
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Patent number: 12290350Abstract: A patient ventilation system and a computing device-implemented method determine oxygen consumption in a mechanically ventilated subject includes receiving a signal representing a total flow at an inspiratory outlet of a ventilator, calculating a transport delay time between inspiratory and expiratory gas sample points in a patient ventilation circuitry, transmitting a signal to an inlet selector valve to selectively open a fluid path between the inspiratory gas sample point and an oxygen sensor or between the expiratory gas sample point and the oxygen sensor, receiving data representing oxygen content and carbon dioxide content over a period of time, calculating oxygen consumption data over the period of time from the data representing the total flow, oxygen content and carbon dioxide content and from the transport delay time, and displaying the oxygen consumption data over the period of time.Type: GrantFiled: November 9, 2018Date of Patent: May 6, 2025Assignees: Children's Medical Center Corporation, COSMED S.r.l.Inventors: Peter Clemensen, John Kheir, Brian Polizzotti, Arne Bo Thomsen
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Publication number: 20250134985Abstract: Provided herein, in some aspects, are methods for using the receptor-binidng domain (RBD) of the SARS-COV-2 S protein, including the the RBD-1, RBD-2, and/or RBD-3 regions, to identify therapeutics for the treatment of SARS-COV-2, developing a vaccine for the treatment or prevention of SARS-COV-2, and identifying a patient as being in need for a treatment for SARS-COV-2.Type: ApplicationFiled: August 16, 2022Publication date: May 1, 2025Applicant: Children's Medical Center CorporationInventor: Bing Chen
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Publication number: 20250134949Abstract: Described herein are compositions and methods for treating a lung disorder associated with dysregulated VEGF signaling. The PR1P peptide (DRVQRQTTTVVA, SEQ ID NO: 1) and variants thereof are able to enhance VEGF signaling in the lungs and reduce lung cell apoptosis (e.g., induced by toxicity or injury), thus treating the disorder.Type: ApplicationFiled: June 12, 2024Publication date: May 1, 2025Applicant: Children's Medical Center CorporationInventors: Avner Adini, Benjamin Matthews
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Publication number: 20250138121Abstract: Described herein are various embodiments of techniques for controlling creation of a magnetic resonance (MR) image from a magnetic resonance imaging (MRI) scan of a subject using an MRI scanner, through real-time, dynamic control of the MRI scanner during the MRI scan and/or of processing during the MRI scan of acquired MR signals as part of generating MR data for creation of the MR image. More particularly, some embodiments described herein relate to identifying changes that occur in a magnetic field within an MRI scanner during a course of an MRI scan. In response to changes in the magnetic field, an MRI scanner may be adjusted to change a way in which additional MR data is captured and/or a processing of captured MR signals (that are to be used in generating an MR image) may be adjusted.Type: ApplicationFiled: August 19, 2022Publication date: May 1, 2025Applicant: Children's Medical Center CorporationInventors: Tess E. Wallace, Simon K. Warfield, Onur Afacan
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Patent number: 12285459Abstract: Disclosed herein are polypeptides and fusion polypeptides that have anti-angiogenic activity that can be used to inhibit tumor growth and tumor metastasis. The polypeptide consists of 9 or less consecutive amino acid residues (e.g., 8, 7, 6, 5, or 4) comprising the active core amino acid sequence DWLP, or an amino acid substitution variant thereof. Specific amino acid substitutions are disclosed herein. In some embodiments, the peptide consists essentially of 4-6 mers identified as exhibiting the activity of prosaposin A. Also disclosed herein are therapeutic compositions comprising the polypeptides and fusion polypeptides, and their use in the treatment, prevention, and inhibition of angiogenesis-related diseases and disorders such as cancer and cancer metastasis.Type: GrantFiled: January 31, 2023Date of Patent: April 29, 2025Assignee: CHILDREN'S MEDICAL CENTER CORPORATIONInventor: Randolph S. Watnick
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Publication number: 20250129093Abstract: Described herein are compositions, combinations, and methods relating to treating or preventing immune-related diseases, type 1 diabetes, transplant rejection, or lung fibrosis, or slowing or delaying aging processes or extending lifespan in a subject, including subjects with rs3751143.Type: ApplicationFiled: February 13, 2023Publication date: April 24, 2025Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Paolo FIORINA, Moufida Ben NASR
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Patent number: 12281313Abstract: Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells, and methods of treating sensory transduction disorders associated with a genetic defect.Type: GrantFiled: September 2, 2020Date of Patent: April 22, 2025Assignee: Children's Medical Center CorporationInventors: Jeffrey R. Holt, Yukako Asai, Paola Andrea Solanes Vega, Bernard Schneider
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Publication number: 20250120963Abstract: This disclosure relates to methods and compositions for the treatment of thrombocytopenia.Type: ApplicationFiled: October 10, 2024Publication date: April 17, 2025Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Roelof H. Bekendam, Andrew P. Stone, Kellie Rae Machlus, Joseph Edward Italiano, JR.
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Patent number: 12274413Abstract: A robotic system comprising a robotic catheter steerable by a motorized drive system, an imaging device positioned on a distal end of the robotic catheter, and a controller configured to: process one or more images captured by the imaging device to identify an anatomical feature, implanted device, or medical instrument; estimate a location of the imaging device in the body based on the identified anatomical feature, implanted device, or medical instrument; determine, based on the estimated location of the imaging device, a direction in which to steer the robotic catheter for advancement towards an interventional site; and monitor at least one of (i) a stream of images captured by the imaging device and (ii) a force or distance measurement captured by the imaging device or a sensor proximate the imaging device, to adjust the direction in which to steer the robotic catheter during advancement towards the interventional site.Type: GrantFiled: January 21, 2021Date of Patent: April 15, 2025Assignee: Children's Medical Center CorporationInventors: Pierre E. Dupont, Georgios Fagogenis, Benoit Rosa, Margherita Mencattelli, Zurab Machaidze
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Publication number: 20250114443Abstract: The present application is generally directed to novel pneumococcal polypeptide antigens and nucleic acids encoding such antigens, and immunogenic compositions comprising such antigens for treating and preventing pneumococcal infection. The present invention further provides method of using the antigens to elicits an immune response (e.g., IL-17A response, a T cell-mediated and/or B-cell-mediated immune responses). The present invention also provides methods of prophylaxis and/or treatment of pneumococcal-mediated diseases, such as sepsis, comprising administering an immunogenic composition including one or more of a combination of pneumococcal antigens or functional fragments thereof as disclosed herein. In some embodiments, one or more pneumococcal antigens can be present in a polysaccharide conjugate. The compositions induce an anti-pneumococcus immune response when administered to a mammal.Type: ApplicationFiled: August 9, 2024Publication date: April 10, 2025Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Richard MALLEY, Yingjie LU, Fan ZHANG
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Patent number: 12268739Abstract: Provided herein are Toll-like receptor 2 (TLR2) agonists for use in enhancing human immune response and/or as adjuvants in vaccines. The TLR2 agonists include thiophenes, imidazoles, or phenyl-containing compounds, which may be compounds of Formulae (I), (II), (III), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein are used as enhancers of an immune response (e.g., innate and/or adaptive immune response), and are useful in treating and/or preventing a disease, as adjuvants in a vaccine for the disease. (e.g., proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.Type: GrantFiled: July 26, 2019Date of Patent: April 8, 2025Assignees: Children's Medical Center Corporation, Dana-Farber Cancer Institute, Inc.Inventors: David J. Dowling, Ofer Levy, Francesco Borriello, David A. Scott, Spencer E. Brightman
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Publication number: 20250101381Abstract: The present invention is directed to compositions and methods to increase the expression of PD-L1 and/or IDO-1 in a population of cells, the modulated cells expressing increased PD-L1 and/or IDO-1, and methods related to the immunosuppressive effects obtained by cells expressing increased PD-L1 and/or IDO-1.Type: ApplicationFiled: April 11, 2024Publication date: March 27, 2025Applicant: The Children's Medical Center CorporationInventor: Paolo Fiorina
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Patent number: 12251525Abstract: A device for performing intervention procedures includes an elongated body having a first end and a second end. The elongated body includes a hollow tool channel extending through the elongated body from the first end to the second end. The tool channel is configured to receive an intervention tool and a length-adjusting element disposed at the first end or the second end of the elongated body. The length-adjusting element is configured to enable a length of the elongated body to be adjusted. The elongated body includes an angle-adjusting element disposed along the length of the elongated body. The angle-adjusting element is configured to enable the elongated body to be bent. The device includes an imaging system disposed at the first end or the second end of the elongated body. The imaging system includes an imaging device and an illumination device.Type: GrantFiled: November 7, 2018Date of Patent: March 18, 2025Assignee: Children's Medical Center CorporationInventors: Mossab Y. Saeed, Pedro J. Del Nido, Nikolay V. Vasilyev, Niv Ad, Christopher J. Payne
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Patent number: 12252515Abstract: Provided herein are agents that bind to the lipid binding groove of Frizzled (FZD). In some embodiments, the agent is a fragment of TcdB corresponding to amino acids 1285-1804 of SEQ ID NO: 1. In some embodiments, binding of the agent to the lipid binding groove of FZD inhibits TcdB entry into cells, and/or inhibits Wnt signaling. Methods of treating Clostridium difficile infection (CDI) and methods of treating cancer are also provided.Type: GrantFiled: January 14, 2019Date of Patent: March 18, 2025Assignees: Children's Medical Center Corporation, The Regents of the University of CaliforniaInventors: Min Dong, Liang Tao, Rongsheng Jin, Peng Chen, Aina He
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Patent number: 12252507Abstract: This disclosure provides methods for generating functionalized nanoswitches, as well as the functionalized nanoswitches themselves, and methods of use thereof.Type: GrantFiled: December 5, 2017Date of Patent: March 18, 2025Assignees: Children's Medical Center Corporation, President and Fellows of Harvard CollegeInventors: Darren Yang, Eric M. Mulhall, Hongyu Zhao, Andrew Ward, Clinton H. Hansen, Wesley Philip Wong
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Publication number: 20250082688Abstract: The present disclosure relates to compositions and methods for treating Williams syndrome (WS), herein identified as a neurodevelopmental oligodendrocyte hypomyelination-associated disease, and to compositions and methods for treatment of other neurodevelopmental myelination abnormality diseases or disorder.Type: ApplicationFiled: November 22, 2024Publication date: March 13, 2025Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Guoping Feng, Boaz Barak, Zhigang He
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Patent number: 12241888Abstract: Provided herein are methods of determining whether an extracellular vesicle (EV) can cross an endothelial barrier (e.g., the blood brain barrier). In some embodiments, the EV originates from a cancer cell. In some embodiments, the cancer has a higher likelihood of metastasizing (to the brain) if the EV originating from a cancer cell is determined to be able to cross an endothelial barrier (e.g., the blood brain barrier). Thus, further provided herein are methods of determining whether a subject who has cancer is likely to develop metastatic cancer. In some embodiments, the subject is treated for the metastatic cancer accordingly.Type: GrantFiled: March 14, 2019Date of Patent: March 4, 2025Assignee: Children's Medical Center CorporationInventors: Marsha A. Moses, Golnaz Morad