Patents Assigned to Children's Medical Center Corporation
  • Publication number: 20240417695
    Abstract: The technology described herein relates to compositions and methods of generating endothelial niche cells. Embodiments of the technology described herein comprise compositions, kits, vectors, and methods related to generating or engineering endothelial niche cells. One aspect comprises a method to generate/engineer endothelial niche cells, comprising expressing one or more transcription factors in an endothelial cell, wherein the one or more transcription factors are from the Ets family, the Sox family, and/or the Nuclear Hormone (NHR) family.
    Type: Application
    Filed: September 4, 2024
    Publication date: December 19, 2024
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Leonard I. ZON, Elliott J. HAGEDORN
  • Patent number: 12168700
    Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
    Type: Grant
    Filed: September 1, 2023
    Date of Patent: December 17, 2024
    Assignees: Children's Medical Center Corporation, Beth Israel Deaconess Medical Center, Inc.
    Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
  • Publication number: 20240407825
    Abstract: An electrocautery device with a retractable suction tube is described. The electrocautery device includes a suction tube assembly that can move between an extended or retracted position using vacuum force generated by a suction source. In some embodiments, the suction tube assembly automatically locks into the extended position when extended such that axial force cannot cause the suction tube assembly to retract. The device may be suitable for use in laparoscopic procedures. The suction tube may be coaxially aligned with the electrocautery tip.
    Type: Application
    Filed: August 15, 2024
    Publication date: December 12, 2024
    Applicant: Children's Medical Center Corporation
    Inventors: Heung Bae Kim, Gabriel J. Ramos-Gonzalez, Alexander Yang
  • Patent number: 12161663
    Abstract: The present invention provides compositions and methods for targeting cells for therapeutic and/or diagnostic purposes, e.g., delivery of therapeutic and/or diagnostic agents to a cell. Nanoparticles and polymers functionalized with capture molecules, reporter molecules, and/or therapeutic agents are provided for the treatment or prevention of disease, including neurological diseases associated with neuroinflammation, and cancer.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: December 10, 2024
    Assignees: Children's Medical Center Corporation, Politecnico di Milano, Dana-Farber Cancer Institute, Inc.
    Inventors: Marco Peviani, Alessandra Biffi, Davide Moscatelli, Umberto Capasso Palmiero, Renato Auriemma, Mattia Sponchioni, Letterio Salvatore Politi
  • Publication number: 20240390382
    Abstract: Described herein are methods and compositions for treating cancer. Aspects of the invention relate to administering to a subject having cancer an inhibitor of the super elongation complex (SEC). In various embodiments, the cancer is a blood cancer. Wherein the blood cancer is selected from the group consisting of leukemia, lymphoma, myeloma, and myeloproliferative neoplasms (MPNs).
    Type: Application
    Filed: September 22, 2022
    Publication date: November 28, 2024
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Vijay G. Sankaran, Jiawei Zhao, Liam D. Cato
  • Patent number: 12150771
    Abstract: A method of detecting the likelihood of a seizure event in a patient includes at successive expirations of a first time interval, determining a first likelihood that the patient is experiencing a seizure based on electrodermal activity and a movement of a limb of the patient. The method also includes at successive expirations of a second time interval, determining whether the patient experienced a seizure in a second time period preceding the determining based on a heart rate of the patient. In response to determining that the third comparison result satisfies at least a third detection criterion, the method compares electrodermal activity and the movement of a limb of the patient to determine a second likelihood. In response to determining that the second likelihood satisfies a second detection criterion, the method triggers presentation of a second alert regarding a potential seizure.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: November 26, 2024
    Assignees: Children's Medical Center Corporation, Wentworth Institute of Technology
    Inventors: Tobias Loddenkemper, Hamed Salehizadeh
  • Publication number: 20240382151
    Abstract: Described herein are techniques to aid clinicians and researchers in determining a condition of connective tissue as it relates to tissue development, growth and maturation, tissue remodeling and healing following injury, and risk of injury based on a magnetic resonance (MR) image of the tissue. Such techniques may be useful to clinicians by providing insights on factors that influence the growth and maturation of convective tissues as well as those that impact the risk of connective tissue injury and response to treatment. These insights can be used to guide or develop patient specific risk assessment and prevention strategies, treatment plans, and postoperative care plans for individuals at risk of connective tissue injuries and those with injured connective tissues, such as an anterior cruciate ligament (ACL) injury.
    Type: Application
    Filed: August 26, 2022
    Publication date: November 21, 2024
    Applicants: Children's Medical Center Corporation, RHODE ISLAND HOSPITAL
    Inventors: Ata Kiapour, Martha M. Murray, Braden C. Fleming, Sean W. Flannery, Davood Karimi, Ali Gholipour-Baboli
  • Publication number: 20240376176
    Abstract: Compositions and methods for the administration of active agents are generally described. In some embodiments, compositions comprising peptide moieties are described. The peptide moieties may comprise sodium channel peptide sequences, such as TQDYWEN (SEQ ID NO: 1) and/or CGEWIET (SEQ ID NO: 2). According to certain embodiments, the peptide moieties are connected to a hydrophobic domain. The presence of both the peptide moiety and the hydrophobic domain may drive self-assembly (e.g., to form a supramolecular nanostructure). The supramolecular nanostructure may facilitate cooperative interaction between distinct peptide sequences. In some embodiments, the peptide sequences bind to the active agents. Binding between the active agent and the peptide sequences may advantageously facilitate controlled release of the active agent. In the context of the present disclosure, it has been inventively recognized that drug delivery may be improved through the use of compositions and methods described herein below.
    Type: Application
    Filed: July 8, 2022
    Publication date: November 14, 2024
    Applicant: Children's Medical Center Corporation
    Inventors: Tianjiao Ji, Daniel S. Kohane
  • Publication number: 20240376225
    Abstract: Provided herein are anti-CD21 antibodies or antigen binding fragments thereof and their use in the treatment of autoimmune diseases or disorders.
    Type: Application
    Filed: July 6, 2022
    Publication date: November 14, 2024
    Applicants: The Children's Medical Center Corporation, PFIZER INC.
    Inventors: Hulian GAO, Michael C. CARROLL, Oleg Victorovich KOVALENKO, Eric Matthew BENNETT, Janet Elizabeth BUHLMANN, Xianchun TANG, Stefano Vincenzo GULLA, Nathan HIGGINSON-SCOTT, Fridrik Jensen KARLSSON, Dulce SOLER-FERRAN, Jessica Haewon MIN DEBARTOLO
  • Patent number: 12137896
    Abstract: A suturing system and a method thereof are provided. The suturing system includes a tube that has a first rod moveable therein and a second rod that is coupled to an outer surface of the tube. A needle is coupled to an end of the tube and includes an insertion portion. In addition, a suture lock is inserted onto the second rod and a first end of a suture engages with a tip of the needle or the tube. A second end of the suture is fixed within the suture lock. The insertion portion is engaged with the first end of the suture prior to insertion through the material. The suturing system allows for single handed operation, thus simplifying a suturing process while improving accuracy.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: November 12, 2024
    Assignee: Children's Medical Center Corporation
    Inventor: Kaifeng Liu
  • Publication number: 20240358502
    Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.
    Type: Application
    Filed: May 6, 2024
    Publication date: October 31, 2024
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Elazer R. Edelman, Peter E. Hammer, Christopher Payne
  • Patent number: 12129491
    Abstract: Described herein are methods and compositions relating to the provision and/or differentiation of certain fully differentiated lung cell types, including surfactant producing cells (e.g. club secretory cells), mucus producing (Goblet) cells, mucus-producing goblet like cells, and beating ciliated cells. In some embodiments, one or more of the differentiated lung cell types is present in an organoid. Differentiation of these lung cell types can be induced by contacting lung stem and/or progenitor cells with one or more inhibitors of H3K9me1/2 methyltransferase, e.g., an inhibitor of G9a and/or G1p (EMHT2 and/or EHMT1).
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: October 29, 2024
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Carla F. Kim, Samuel P. Rowbotham, Joo-Hyeon Lee
  • Publication number: 20240353517
    Abstract: Described herein are techniques to estimate motion of a subject during a magnetic resonance image (MRI) scan. The estimation may be based on one or more slices acquired during the MRI scan, permitting automated estimation of motion of the subject during the MRI scan. Some such techniques may be performed during the MRI scan, before the completion of the MRI scan, or after the MRI scan before or after magnetic resonance data (MR data) resulting from the MRI scan has been processed to generate an image from the MR data.
    Type: Application
    Filed: August 19, 2022
    Publication date: October 24, 2024
    Applicant: Children's Medical Center Corporation
    Inventors: Yao Sui, Onur Afacan, Ali Gholipour-Baboli, Simon K. Warfield
  • Publication number: 20240352154
    Abstract: Described herein are compositions (e.g. cells and transgenic animals) and methods relating to engineered Ig loci that permit expression of particular antibodies or antibody segments while still permitting recombination and/or maturation process for antibody optimization.
    Type: Application
    Filed: March 18, 2024
    Publication date: October 24, 2024
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Frederick W. ALT, Suvi JAIN, Zhaoqing BA, Ming TIAN
  • Patent number: 12121215
    Abstract: A device for performing surgical procedures, such as intracardiac procedures or neurosurgical procedures, includes a solid optical window formed of a transparent, compliant material, wherein the solid optical window includes a proximal side and a distal side, wherein a distal face of the solid optical window is configured to approach tissue during a surgical procedure; an imaging system embedded into the solid optical window and positioned to obtain an image through at least a portion of the distal face of the solid optical window; and a tool channel formed through the solid optical window from the proximal side to the distal side of the solid optical window, wherein the tool channel is configured to receive a tool for performing the surgical procedure.
    Type: Grant
    Filed: September 29, 2022
    Date of Patent: October 22, 2024
    Assignee: Children's Medical Center Corporation
    Inventor: Pierre Dupont
  • Patent number: 12123869
    Abstract: Provided herein, inter alia, are improved methods for detecting analytes, including proteins and nucleic acids. In some instances, the analytes are detected in complex matrices such as serum.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: October 22, 2024
    Assignee: Children's Medical Center Corporation
    Inventors: Clinton H. Hansen, Wesley Philip Wong, Darren Yang, Andrew Ward
  • Publication number: 20240342173
    Abstract: The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.
    Type: Application
    Filed: February 13, 2024
    Publication date: October 17, 2024
    Applicants: THE CHILDREN'S MEDICAL CENTER CORPORATION, DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: James BRADNER, Jun QI, Dennis BUCKLEY, Leonard I. ZON, Elizabeth MACARI
  • Patent number: 12114910
    Abstract: An electrocautery device with a retractable suction tube is described. The electrocautery device includes a suction tube assembly that can move between an extended or retracted position using vacuum force generated by a suction source. In some embodiments, the suction tube assembly automatically locks into the extended position when extended such that axial force cannot cause the suction tube assembly to retract. The device may be suitable for use in laparoscopic procedures. The suction tube may be coaxially aligned with the electrocautery tip.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: October 15, 2024
    Assignee: Children's Medical Center Corporation
    Inventors: Heung Bae Kim, Gabriel J. Ramos-Gonzalez, Alexander Yang
  • Patent number: 12117448
    Abstract: The invention relates to isolated peptides and chimeric polypeptides derived from Saposin A that have anti-angiogenic activity. These peptides are small, consisting essentially of at least 10 consecutive amino acid residues from the 31st-50th amino acid residue of Saposin A. The invention also relates to the use of these isolated peptides and chimeric polypeptides in compositions for the treatment, prevention, and inhibition of angiogenesis-related diseases and disorders such as cancer and cancer metastasis.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: October 15, 2024
    Assignee: Children's Medical Center Corporation
    Inventor: Randolph Watnick
  • Patent number: 12110553
    Abstract: This document features method related to variants in the Inverted Formin 2 (INF2) gene that are associated with susceptibility to focal segmental glomerulosclerosis (FSGS). For example, methods of using such variants for risk assessment and for diagnosing and optimizing treatment of FSGS are provided.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: October 8, 2024
    Assignees: The Brigham and Women's Hospital, Inc., Children's Medical Center Corporation
    Inventors: Martin Pollak, Elizabeth J. Brown, Johannes Schlondorff