Abstract: The invention relates to therapeutic vaccines for the treatment of neoplasias caused by the human papillomavirus (HPV). In particular, the vaccines of the present invention are formed by chimeric virus-like capsids of birnavirus containing papillomavirus antigens.
Type:
Grant
Filed:
November 5, 2010
Date of Patent:
February 10, 2015
Assignee:
Chimera Pharma, S.L.U
Inventors:
Thomas Zurcher, Cayetano Von Kobbe, Juan J. Bernal, Ignacio Jiménez Torres, Gloria Calderita Lucas, Margarita Rodriguez Garcia, Ana Garzon Gutierrez, Virginia Gondar Sousa E Silva, Arcadio García De Castro, Irene Pino De La Huerga
Abstract: The field of the invention refers to chimeric Virus Like Particles (VLP) derived from Birnavirus chimeric VP2 protein. In particular, the invention refers to chimeric VP2 fusion proteins which incorporate insertions and/or substitutions with one or more amino acids or particular peptide of interest while maintaining the capacity to assemble in the form of VLP. The invention identifies particular insertion and/or substitutions sites within VP2 P loop regions and outside said P loop regions. The invention also incorporates methods for the identification of preferred insertion and substitution sites within VP2 for the incorporation of particular amino acids and peptides of interest. The resulting chimeric VLP are of interest in the design of therapeutic and prophylactic vaccines as well as in the design of drug delivery systems, carriers for DNA and RNA in gene therapy, as targeted agents, in the development of antitoxins, and as diagnostic reagents.
Type:
Grant
Filed:
May 9, 2008
Date of Patent:
July 22, 2014
Assignee:
Chimera Pharma S.L.U
Inventors:
Thomas Zürcher, Juan José Bernal, Cayetano von Kobbe, Ignacio Jiménez Torres, Ana Diaz Blázquez, Diana Martin Lorenzo, Gloria Calderita Lucas, Arcadio Garcia de Castro
Abstract: The invention relates to therapeutic vaccines for the treatment of neoplasias caused by the human papillomavirus (HPV). In particular, the vaccines of the present invention are formed by chimeric virus-like capsids of birnavirus containing papillomavirus antigens.
Type:
Application
Filed:
November 5, 2010
Publication date:
October 25, 2012
Applicant:
Chimera Pharma, S.L.U.
Inventors:
Thomas Zurcher, Cayetano Von Kobbe, Juan J. Bernal, Ignacio Jiménez Torres, Gloria Calderita Lucas, Margarita Rodriguez Garcia, Ana Garzon Gutierrez, Virginia Gondar Sousa E Silva, Arcadio Garcia De Castro, Irene Pino De La Huerga
Abstract: The chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV) are formed by the assembly of fusion proteins comprising a region A consisting of an IBDV pVP2 protein or a “1-n” fragment of said IBDV pVP2, wherein “n” is an integer comprised between 441 and 501, bound to a region B consisting of a heterologous polypeptide comprising a polypeptide of interest, such as a polypeptide useful for prophylactic, therapeutic or diagnostic purposes.
Type:
Grant
Filed:
May 11, 2006
Date of Patent:
January 13, 2009
Assignee:
Chimera Pharma S.L.U.
Inventors:
Jose Francisco Rodriguez Aguirre, Jose Ruiz Caston, Irene Saugar Gomez, Ana Maria Ona Blanco, Juan Ramon Rodriguez Fernandez-Alba