Abstract: A novel manufacturing method for membrane controlled programmable trans-dermal therapeutic systems (PTTS) comprises highly stabilized supersaturated drug solid solution system and easily adjustable controlled release membrane. The features of the programmable transdermal therapeutic system are as follows:1. The PTTS release drugs continuously through the skin with long duration into the systemic blood circulating system with adequate therapeutic effect.2. The release rate of the TTS can be pre-programmed to decrease day by day according to a schedule of decreased symptoms, so side effects may be relieved greatly.