Abstract: Disclosed are a biomarker, method and assay kit for identifying and screening for urothelial carcinoma (UC) in a subject in need.

Abstract: The invention provides a novel class of propiolylamide-based irreversible inhibitors of PKM2 compounds of the general formula I, pharmaceutical compositions, and methods of inducing an anti-tumor effect in a subject suffering from tumor comprising administering to the subject a pharmaceutical composition comprising an effective amount of compound of formula I.

Abstract: A method of repairing an oral defect model includes performing a three-dimensional oral defect model obtaining step, a defect cutting line detecting step, a defect point selecting step and a smoothing step. The three-dimensional oral defect model obtaining step is performed to scan an oral cavity to obtain a three-dimensional oral defect model message. The defect cutting line detecting step is performed to detect a defect cutting line of the three-dimension oral defect model message, and drive a displayer to display the defect cutting line. The defect point selecting step is performed to select at least one defect feature point of the defect cutting line via the displayer. The smoothing step is performed to perform a smoothing process at the at least one defect feature point, and convert the three-dimensional oral defect model message into a three-dimensional oral repaired model message to smooth the defect cutting line.

Abstract: The present invention develops a series of methyl caffeate derivatives having biological activity in anti-angiogenesis. The present invention suggests that the compounds of the invention possess inhibiting angiogenesis through regulation of VEGF/VEGFR-2 and its downstream signaling cascades in the vascular endothelial cells (VECs).

Abstract: A method of medical image registration is to be implemented by a computer device, and includes steps of: obtaining an ultrasound target image corresponding to an area of interest in an ultrasound image; for each of multiple computed tomography (CT) images, obtaining a CT candidate image that corresponds to an area of interest in the CT image; for each of the CT candidate images, calculating a similarity between the CT candidate image and the ultrasound target image; making one of the CT candidate images that corresponds to the greatest similarity among the CT candidate images serve as a CT target image; and performing image registration on the ultrasound target image and the CT target image.

Abstract: The present invention provides a biomarker, method and assay kit for identifying and screening nephropathy, particularly diabetic nephropathy, in a subject in need, or predicting diabetic nephropathy or early progressive renal function decline (ERFD) in a diabetic patient.

Abstract: A positioning guidance method for tooth brackets is provided. The positioning guidance method includes: obtaining, via an image capturing unit, an oral image; obtaining, via a processor, a position of a candidate tooth according to the contour of a plurality of teeth in the oral image; obtaining, via the processor, a bracket setting position corresponding to the candidate tooth by accessing dental model information from a storage device according to the position of the candidate tooth; obtaining, via the processor, a bracket image corresponding to a bracket from the oral image; and displaying, via the processor, guidance indication on a display unit according to a bracket position corresponding to the bracket image and the bracket setting position.

Abstract: Methods and compositions for treating diabetic retinopathy employ an ophthalmic, topical formulation of micro-RNA 195 packaged in or on a nanoparticle or vesicle.

Abstract: The present disclosure provides a bone age assessment and height prediction system including an image capturing unit and a non-transitory machine readable medium. The image capturing unit is for obtaining a target x-ray image data of a subject. The non-transitory machine-readable medium is for storing a program for assessing the development of the bones of a hand and the bone age of the subject, and predicting the adult height of the subject when executed by a processing unit. Therefore, the bone age assessment and height prediction system of the present disclosure can effectively improve the accuracy and sensitivity of the bone age assessment and the height prediction, and the time for assessing the bone age and predicting the height can be further shorten.

Abstract: The present disclosure relates to a HLA-G specific chimeric antigen receptor, a nucleic acid, a HLA-G specific chimeric antigen receptor expression plasmid, a HLA-G specific chimeric antigen receptor expressing cell, a pharmaceutical composition for treating cancer, and use of the HLA-G specific chimeric antigen receptor expressing cell. The chimeric antigen receptor specifically binds to human leukocyte antigen G. The nucleic acid encodes the HLA-G specific chimeric antigen receptor. The HLA-G specific chimeric antigen receptor expression plasmid expresses the HLA-G specific chimeric antigen receptor. The HLA-G specific chimeric antigen receptor expressing cell is obtained by transducing the HLA-G specific chimeric antigen receptor into an immune cell. The pharmaceutical composition for treating cancer includes the HLA-G specific chimeric antigen receptor expressing cell and a pharmaceutically acceptable carrier.

Abstract: A method for obtaining a plurality of pluripotent adult olfactory stem cells (APOSCs) includes isolating the APOSCs, culturing the isolated APOSCs in a sphere culture medium, and collecting the cultured APOSCs that express Bmi-1 (B-lymphoma moloney murine leukemia virus insertion region-1), Oct-4 (Octamer-binding transcription factor 4), Sox-2 (Sex-determining region Y (SRY)-box 2), Nanog, SSEA-4 (Stage-specific embryonic antigen-4), ki67, c-Myc, KLF-4 (Kruppel Like Factor 4), K14 (Cytokeratin 14) and ICAM-1 (Intercellular Adhesion Molecule 1).

Abstract: A thermopuncture stent implantation device has a proximal end and a distal end, the distal end of a front handle is provided with an outer tube, an insulating middle tube is provided in the outer tube, a conductive part is provided in the insulating middle tube, a terminal of the proximal end of the conductive part is connected to an external power source, a boosting tube is provided between the proximal end of the outer tube and the insulating middle tube, the distal end of the boosting tube and the proximal end of the insulating middle tube are connected with each other, the distal end of the conductive part is provided with an insulating part, on which a conductive head connected with the conductive part is distributed; the stent, after being compressed, is located in a space between the distal end of the conductive part and the outer tube.

Abstract: The invention discloses a methodology for the biomimetic culture of urothelial cells from mammalian bladders, including murine, porcine, bovine and human sources to isolate and expand urothelial cells for use in various applications, such as intravesical urothelial cell therapy to treat cystitis and bladder cancer.

Abstract: A method of medical image registration is to be implemented by a computer device, and includes steps of: obtaining an ultrasound target image corresponding to an area of interest in an ultrasound image; for each of multiple computed tomography (CT) images, obtaining a CT candidate image that corresponds to an area of interest in the CT image; for each of the CT candidate images, calculating a similarity between the CT candidate image and the ultrasound target image; making one of the CT candidate images that corresponds to the greatest similarity among the CT candidate images serve as a CT target image; and performing image registration on the ultrasound target image and the CT target image.

Abstract: An implant surface mapping and unwrapping method provided by the present invention selects or defines a mesh implant geometry, and places and rotates it in a specific spatial position according to a mesh. Vertex space coordinates, which are interpolated in medical images such as computed tomography, magnetic resonance imaging, or ultrasound to calculate the gray scale values of these spatial coordinate points, and map them on the surface of the implant. In addition, the implant is irregular. The surface can be further unwrapped through the planar image to help understand its contact with the anatomy. If the medical image is pre-converted to other anatomical, physiological, pathological, and functional parameters, the mapping and unwrapping results will also be displayed with these parameters. Learn more about the relationship between implants and these parameters.

Abstract: The present disclosure relates to an ADAM9 inhibitor compound of formula (I), including salts, hydrates and stereoisomers thereof, compositions thereof, and methods of use therefor, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

Abstract: A prediction system of tumor image-aided prediction of prognosis for patients with uterine cervical cancer is provided. The prediction system includes a data augmentation module and a deep convolution neural network model. The data augmentation module is used to apply a data expansion process of the image data, so as to generate a plurality of slice sets of the uterine cervical cancer tumor. The deep convolution neural network model is used to apply a feature analysis to the slices, so as to predict the prognosis of a patient after chemoradiotherapy.

Abstract: A simulated method and system for surgical instrument based on tomography are provided. The method includes obtaining a biological stereoscopic image and inputting a parameter set of an implant to be implanted, denoting a target position and an initial position in the biological stereoscopic image, estimating a dimensional coordinate of a contact area of the implant and a living organism when the implant has been implanted into the living organism based on the parameter set, the target position and the initial position in the biological stereoscopic image, and obtaining a physiological data set by re-sampling corresponding to the dimensional coordinate of the implant in the living organism for evaluating the effect after the implant has been implanted into the living organism. Surgeons may evaluate the effect after implantation of implant into the living organism by using the simulated method, enhancing the overall quality and result of the surgery.

Abstract: A method for converting scan information of computed tomography scanner into bone parameters includes the steps of: providing a computed tomography scanner; providing a test object and two phantoms of known components; using the computed tomography scanner to obtain a corresponding test object scan information and two phantoms scan information; receiving the test object scan information and the two phantoms scan information through a computing device; using the computing device to calculate an energy attenuation coefficient of the computed tomography scanner through a physical function model including the known components and the two phantoms scan information; providing the computing device with an energy correction coefficient; and enabling the computing device to obtain a bone parameter of the test object through a true relationship function that includes the energy attenuation coefficient, the test object scan information and the energy correction coefficient.

Abstract: A cell mechanical stimulating device for applying to at least one cell sample is provided. The device includes a base unit, at least one moving component and at least one magnetic component. The base unit includes a base body and a separating lid. The base body includes at least one culturing chamber and a bottom chamber surface. The cell sample is disposed in the culturing chamber, and the separating lid encloses the culturing chamber. The magnetic component drives the moving component to shift between a pressurizing position and a non-pressurizing position. At the pressurizing position, the moving component moves toward the bottom chamber surface and pressurizes the cell sample. At the non-pressurizing position, the moving component moves toward the separating lid and the pressure on the cell sample is removed. The cell sample is pressurized by the magnetic component driving the moving component.