Abstract: Isoflavone fatty acid ester derivatives of formula (I) or (II), the preparation method thereof and the pharmaceutical compositions containing such compounds are disclosed. The uses of such compounds in preparation of medicaments for preventing or treating hyperlipidemia, obesity or type II diabetes are also disclosed.
Type:
Application
Filed:
March 1, 2010
Publication date:
March 28, 2013
Applicant:
CHINA PHARMACEUTICAL UNIVERSITY
Inventors:
Hua Xiang, Wei Zhao, Hong Xiao, Yao Yao, Renling Ma, Lei Qian, Xiaobo Li, Qidong You, Qingjiang Liao
Abstract: The present invention relates to the field of natural drugs, particularly to 6-shogaol for using in a method for the treatment of leukemia. The present invention provides a method for treating leukemia by applying a therapeutically effective dose of 6-shogaolt and this therapeutic method can be used for treating leukemia in mammals including human being.
Abstract: A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as ?-opioid receptor excitant in pain relieving, which belongs to the medicine chemistry. The substituents R1, R2, R3, R4 of general formula (I) are defined as the description.
Type:
Grant
Filed:
July 10, 2007
Date of Patent:
October 26, 2010
Assignees:
China Pharmaceutical University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Yangtze River Pharmaceutical Group Co., Ltd.
Abstract: Provided is a kind of modified recombinant human endostatin that has the structure of CH3O—(CH2CH2O)m—CH2CH2CH2—N?H-Endostar, wherein the average molecular weight of CH3O—(CH2CH2O)m—CH2CH2CH2— is 20-40 kD. The modified recombinant human endostatin enhances the stability in vivo, improves blood drug concentration, prolongs half-life, markedly increases the activity of inhibiting the endothelial cells proliferation, thus reduces drug dosage and decreases administration frequency. Its application for preparing anti-tumor pharmaceutical compositions is also provided.
Type:
Application
Filed:
September 4, 2008
Publication date:
August 19, 2010
Applicants:
JIANGSU SIMCERE PHARMACEUTICAL R&D CO., LTD., CHINA PHARMACEUTICAL UNIVERSITY, Shandong Xiansheng Maidejin Biologial Pharmaceutia l Co. Ltd
Abstract: The present invention provides a chroman compound of formula (I) and its pharmaceutical salt, methods of its preparation and its pharmaceutical applications. Wherein: X is O or S; n is for 2, 3 or 4; R1 is 6-substituted or 7-substituted halogen, C1-4alkyl, C1-4alkoxyl, benzyloxy, carbamoyl; R2 is nitrogen-containing five-membered or six-membered substituted heterocyclic ring selected from piperidinyl, morpholinyl, N-methyl-piperazinyl, N-(2-ethoxyl)piperazinyl, pyrrolyl, pyrazolyl or imidazolyl. The compounds are useful to prepare medicaments for treating cardiovascular diseases, their preparation employs mild reaction conditions, the raw material are plenty and easy to be obtained, and the operation and post-treatment in the preparation are simple.
Type:
Grant
Filed:
October 25, 2007
Date of Patent:
August 10, 2010
Assignee:
China Pharmaceutical University
Inventors:
Qidong You, Lvpei Du, Minyong Li, Lin Xia
Abstract: The present invention provided a chroman compound, the method of its preparation and pharmaceutical applications. The compound are represented by formula (I) and its pharmaceutical salt, where in :x is for O or S; n is for 2, 3 or 4; R1 is 6-situ or 7-situ halogen, C1-4alkyl, C1-4alkyoxyl, benzyloxy, acylamino; R2 is nitrogen-containing pentatomic or hexahydric substituted heterocyclic ring. The compound is useful to prepare anti-arrhythmic drugs, the reaction conditions of the method are mild, the raw material are plenty and easy to be obtained, and the operation and post-treatment are simple.
Type:
Application
Filed:
October 25, 2007
Publication date:
May 1, 2008
Applicant:
CHINA PHARMACEUTICAL UNIVERSITY
Inventors:
Qidong You, Lvpei Du, Minyong Li, Lin Xia
Abstract: This invention relates to a pharmaceutical composition used for treating cardiovascular diseases and a method for preparing it. The pharmaceutical composition mainly contains polysacchrides, saponins and amino acids extracted from Radix ginseng, Radix ophiopogonis and Fructus schisandrae chinensis. The method of preparing it includes the following steps: Radix ginseng, Radix ophiopogonis and Fructus schisandrae chinensis are decocted together in water; water extract or eluate is precipitated with alcohol or acetone, treated with macroporous adsorption resin and with ion exchange resin, and then separated to obtain pharmaceutical composition containing effective fractions of polysacchrides, saponins and amino acids. The above mentioned pharmaceutical composition can be formed into various preparations by mixing with any pharmaceutically acceptable auxiliary materials.
Type:
Grant
Filed:
December 19, 2001
Date of Patent:
July 22, 2003
Assignees:
China Pharmaceutical University, Ningbo Asia-Pacific Biotechnology Ltd.
Abstract: A tetrahydroprotoberberine quaternary ammonium compound represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R' and X are as defined in the specification. A method of preparing the compound is provided. The compounds can suppress arrhythmia and ventricular fibrillation, protect against myocardial ischemia, and can be conveniently orally administered.
Type:
Grant
Filed:
October 31, 1994
Date of Patent:
November 28, 1995
Assignees:
China Pharmaceutical University, Administrative Center of New Drug Research, The State Pharmaceutical Administration of China
Abstract: The invention provides methods of preparing a male antifertility agent composed of a diterpene lactone compound obtained from plants of the genus Tripterygium, the diterpene lactone compounds obtained from that method, and the use of the compounds as an antifertility agent.
Type:
Grant
Filed:
December 18, 1990
Date of Patent:
July 4, 1995
Assignees:
Jiangsu Family Planning Institute, China Pharmaceutical University, Institute of Dermatology, Chinese Academy of Medical Sciences