Patents Assigned to China Synthetic Rubber Corporation
  • Methods and agents for the diagnosis and treatment of hepatocellular carcinoma
    Patent number: 9545443
    Abstract: The present invention relates to methods of diagnosing and methods of treating hepatocellular carcinoma in a subject. The invention also relates to antagonists of PLVAP proteins, such as antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising antagonists of PLVAP proteins. The invention further relates to humanized antibodies that specifically bind PLVAP protein.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: January 17, 2017
    Assignee: China Synthetic Rubber Corporation
    Inventors: Kuo-Jang Kao, Andrew T. Huang
  • Therapeutic biologic for treatment of hepatocellular carcinoma
    Patent number: 9493552
    Abstract: The invention provides, inter alia, conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular domain epitope of a mammalian PLVAP protein. These agents specifically target HCC tumors and treat the HCC. The invention also provides methods of using these conjugates, such as methods of treating HCC by administering the conjugates provided by the invention or compositions provided by the invention, such as pharmaceutical compositions.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: November 15, 2016
    Assignee: China Synthetic Rubber Corporation
    Inventors: Kuo-Jang Kao, Yun-Hsin Wang
  • Methods and agents for the diagnosis and treatment of hepatocellular carcinoma
    Patent number: 9394359
    Abstract: The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to polypeptide antagonists of PLVAP proteins, including humanized and chimeric antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising such polypeptide antagonists.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: July 19, 2016
    Assignee: CHINA SYNTHETIC RUBBER CORPORATION
    Inventors: Kuo-Jang Kao, Andrew T. Huang
  • Methods and agents for the diagnosis and treatment of hepatocellular carcinoma
    Patent number: 8821880
    Abstract: The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to polypeptide antagonists of PLVAP proteins, including humanized and chimeric antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising such polypeptide antagonists.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: September 2, 2014
    Assignee: China Synthetic Rubber Corporation
    Inventors: Kuo-Jang Kao, Andrew T. Huang
  • Methods and agents for the diagnosis and treatment of hepatocellular carcinoma
    Patent number: 8815240
    Abstract: The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to antagonists of PLVAP proteins, such as antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising antagonists of PLVAP proteins. The invention further relates to humanized antibodies that specifically bind PLVAP protein.
    Type: Grant
    Filed: March 18, 2009
    Date of Patent: August 26, 2014
    Assignee: China Synthetic Rubber Corporation
    Inventors: Kuo-Jang Kao, Andrew T. Huang
  • Gene expression profiling for identification of prognostic subclasses in nasopharyngeal carcinomas
    Patent number: 7998674
    Abstract: mRNA transcript profiling can be used to formulate molecular predictors of distant metastasis for primary NPCs. The predicted results are highly correlated with short metastasis-free and overall survival. Predictions are made using 52-genes based and 12-genes based predictors.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: August 16, 2011
    Assignee: China Synthetic Rubber Corporation
    Inventors: Kuo-jang Kao, Andrew Huang
  • METHODS, AGENTS AND KITS FOR THE DETECTION OF CANCER
    Publication number: 20110159498
    Abstract: The present invention relates to methods of diagnosing a cancer in a subject, and methods of providing a prognosis for a subject that has a cancer. The invention also relates to diagnostic and prognostic kits for cancer.
    Type: Application
    Filed: April 8, 2009
    Publication date: June 30, 2011
    Applicant: China Synthetic Rubber Corporation
    Inventors: Kuo-Jang Kao, Ta-Yuan Chen, To-Yu Huang, Andrew T. Huang