Patents Assigned to China University of Science and Technology
  • Patent number: 11766665
    Abstract: Disclosed is a method for efficiently synthesizing primary amines, which comprises using carbonyl compounds or alcohol compounds as reaction substrate, liquid ammonia or alcohol solutions of ammonia as nitrogen source, and hydrogen as hydrogen source, and reacting in reaction medium catalyzed by a cobalt-based catalyst to obtain the primary amines. Due to high catalytic activity, the method can realize the reductive amination of carbonyl compounds and the hydrogen-borrowing amination of alcohol compounds at low temperatures in a short time to obtain the primary amines with high yield, and is applicable to a wide range of substrates. The obtained primary amines can be used as raw materials with high extra value for producing polymers, medicines, dyes and surfactants. Further, the cobalt-based catalyst has a good industrial application prospect because it is magnetic which can facilitate separation and recycling of the catalyst.
    Type: Grant
    Filed: December 28, 2021
    Date of Patent: September 26, 2023
    Assignee: East China University of Science and Technology
    Inventors: Yanqin Wang, Wanjun Guo, Shuang Xiang, Xiaohui Liu, Yong Guo
  • Patent number: 11767581
    Abstract: The present invention discloses a high nitrogen steel with high strength, low yield ratio and high corrosion resistance for ocean engineering, comprising the following chemical components by weight percentage: C?0.01%, Si?0.1%, Cr 17%-19%, Mn 14%-16%, Mo 1%-1.5%, Ti?0.05%, N 0.45%-0.6%, P?0.01%, S?0.01%, O?0.02%, and the balance of iron. The present invention also discloses a preparation method as follows: (1) raw material weighing; (2) ingot preparation, remelting and smelting; (3) solution and forging treatments; and (4) hot rolling and post-rolling treatment. A product provided by the present invention has high tensile strength, low yield ratio and high corrosion resistance. At the same time, the present invention does not need pressurized equipment in the preparation process, therefore the preparation method is simple, the cost is low, and the present invention is suitable for industrial popularization in China.
    Type: Grant
    Filed: October 17, 2022
    Date of Patent: September 26, 2023
    Assignee: North China University of Science and Technology
    Inventors: Jimeng Liu, Shuhuan Wang, Dingguo Zhao, Yuekai Xue, Hao Li, Cunshuai Zhang
  • Publication number: 20230296616
    Abstract: Provided is an arginine fluorescent probe, comprising a polypeptide B that responds to arginine and a fluorescent protein A that expresses arginine; the fluorescent protein A is inserted into the polypeptide B, B is divided into an upper structural part and a lower structural part, B1 and B2, and a probe structure represented by the formula B1-A-B2 is formed; optimized mutants are likewise obtained by truncation and site-directed mutagenesis at different positions, and specific binding of the polypeptide B and arginine leads to a change in the fluorescence signal of the fluorescent protein A; and the polypeptide B is an arginine binding protein or a mutant thereof.
    Type: Application
    Filed: February 9, 2021
    Publication date: September 21, 2023
    Applicant: East China University of Science and Technology
    Inventors: Yi Yang, Yuzheng Zhao, Rui Li, Yejun Zou, Li Huang, Xie Li, Kun Jiang
  • Publication number: 20230296617
    Abstract: Disclosed is a tryptophan optical probe, a preparation method therefor and the use thereof. Disclosed is an optical probe, comprising a tryptophan-sensitive polypeptide or a functional variant thereof and an optically active polypeptide or a functional variant thereof, wherein the optically active polypeptide or the functional variant thereof is located in the sequence of the tryptophan-sensitive polypeptide or the functional variant thereof. Furthermore, disclosed are a method for preparing the above-mentioned probe and the use thereof in the detection of tryptophan.
    Type: Application
    Filed: February 9, 2021
    Publication date: September 21, 2023
    Applicant: East China University of Science and Technology
    Inventors: Yi Yang, Yuzheng Zhao, Chenxia Zhang, Li Huang, Yejun Zou, Xie Li, Shuning Liu
  • Publication number: 20230286098
    Abstract: A drilling machine tool with a cooling liquid purifying and recycling mechanism. The drilling machine tool comprises a platform in which a blanking hole is formed, wherein air cylinders are fixedly mounted at the top of a transverse plate located above the platform, a lifting plate is mounted after the output shaft ends of the air cylinders penetrate through the transverse plate, an isolation cylinder is arranged below the lifting plate, an opening is formed in the bottom of the isolation cylinder, the bottom end of the vertical shaft slidably penetrates through the isolation cylinder and is fixedly provided with a drill bit, the isolation cylinder is connected with the lifting plate through pressing mechanisms, and a cooling liquid conveying mechanism communicating with the interior of the isolation cylinder is arranged on the platform; and a cooling liquid purifying and recycling mechanism is arranged at the bottom of the platform.
    Type: Application
    Filed: June 8, 2022
    Publication date: September 14, 2023
    Applicant: North China University of Science and Technology
    Inventors: Duo ZHANG, Haoqiang Zhang, Xin Jin, Suoxia Hou, Hongyin Zhao, Xinge Wang
  • Publication number: 20230203506
    Abstract: An optical probe, comprising a lactic acid-sensitive polypeptide or a functional variant thereof and an optically active polypeptide or a functional variant thereof; the optically active polypeptide or the functional variant thereof is located in the sequence of the lactic acid-sensitive polypeptide or the functional variant thereof. A preparation method for the described probe and an application thereof in the detection of lactic acid.
    Type: Application
    Filed: December 21, 2020
    Publication date: June 29, 2023
    Applicant: East China University of Science and Technology
    Inventors: Yi Yang, Yuzheng Zhao, Xie Li, Xiuze Zhang, Li Huang
  • Publication number: 20230115623
    Abstract: The present invention discloses a high nitrogen steel with high strength, low yield ratio and high corrosion resistance for ocean engineering, comprising the following chemical components by weight percentage: C?0.01%, Si?0.1%, Cr 17%-19%, Mn 14%-16%, Mo 1%-1.5%, Ti?0.05%, N 0.45%-0.6%, P?0.01%, S?0.01%, O?0.02%, and the balance of iron. The present invention also discloses a preparation method as follows: (1) raw material weighing; (2) ingot preparation, remelting and smelting; (3) solution and forging treatments; and (4) hot rolling and post-rolling treatment. A product provided by the present invention has high tensile strength, low yield ratio and high corrosion resistance. At the same time, the present invention does not need pressurized equipment in the preparation process, therefore the preparation method is simple, the cost is low, and the present invention is suitable for industrial popularization in China.
    Type: Application
    Filed: October 17, 2022
    Publication date: April 13, 2023
    Applicant: North China University of Science and Technology
    Inventors: Jimeng Liu, Shuhuan Wang, Dingguo Zhao, Yuekai Xue, Hao Li, Cunshuai Zhang
  • Publication number: 20230102416
    Abstract: Disclosed is a method for efficiently synthesizing primary amines, which comprises using carbonyl compounds or alcohol compounds as reaction substrate, liquid ammonia or alcohol solutions of ammonia as nitrogen source, and hydrogen as hydrogen source, and reacting in reaction medium catalyzed by a cobalt-based catalyst to obtain the primary amines. Due to high catalytic activity, the method can realize the reductive amination of carbonyl compounds and the hydrogen-borrowing amination of alcohol compounds at low temperatures in a short time to obtain the primary amines with high yield, and is applicable to a wide range of substrates. The obtained primary amines can be used as raw materials with high extra value for producing polymers, medicines, dyes and surfactants. Further, the cobalt-based catalyst has a good industrial application prospect because it is magnetic which can facilitate separation and recycling of the catalyst.
    Type: Application
    Filed: December 28, 2021
    Publication date: March 30, 2023
    Applicant: East China University of Science and Technology
    Inventors: Yanqin WANG, Wanjun GUO, Shuang XIANG, Xiaohui LIU, Yong GUO
  • Patent number: 11555860
    Abstract: A method for testing a mechanical performance of a lithium ion battery electrode based on a nano-indentation technology includes following steps: connecting an assembled lithium ion battery with an electrochemical test device and setting different test working conditions, so that cyclic charge and discharge experiments are performed on the battery to obtain an attenuation curve of a battery capacity; disassembling the battery and taking out the electrode; scraping some powder from a surface of the cyclic electrode plate and an initial uncyclic electrode plate, and laying down the powder in cold mounting molds separately, pouring the cold mounting solution into the molds; taking out the samples from the molds respectively after the liquid is completely cured and cooled; detecting a mechanical performance after polishing the samples surfaces and analyzing the mechanical performance decay rule of the electrodes.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: January 17, 2023
    Assignee: East China University of Science and Technology
    Inventors: Weiling Luan, Ying Chen, Senming Wu, Haofeng Chen
  • Patent number: 11542474
    Abstract: The present invention provides a recombinant adipose-derived stem cell and a recombinant method thereof, and belongs to the technical field of genetic engineering, where an adenovirus carrying an hFIX gene is transfected into an adipose-derived stem cell to obtain the recombinant adipose-derived stem cell. In the present invention, an adenovirus carrying an hFIX gene is transfected into an adipose-derived stem cell, and the recombinant adipose-derived stem cell obtained after the transfection can express an hFIX protein.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: January 3, 2023
    Assignee: North China University of Science and Technology
    Inventors: Zhenyu Yan, Linhong Wang, Yanyan Xie, Xin Wang
  • Publication number: 20220410108
    Abstract: The present application discloses a multi-region plasma shell-and-tube reactor comprising a shell body. At least two reaction regions are provided inside the shell body, and a horizontal separation panel is provided between any two adjacent reaction regions, used to separate the two and passing through the tubes. A central hole is provided in the center of any horizontal separation panel, and at least one auxiliary hole distributed around the central axis of the central hole is provided in any horizontal separation panel so as to cooperate with the central hole to cause a vortex state to be formed in a reaction region.
    Type: Application
    Filed: November 23, 2020
    Publication date: December 29, 2022
    Applicants: ZHEJIANG WYNCA CHEMICAL INDUSTRY GROUP CO., LTD, EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Zhenmin CHENG, Shengbao JIANG, Shenluan YU, Shuguang ZHOU, Minhai TU, Long QIN, Zhichao JIN, Zibin HUANG, Meichen CHEN, Peiqing YUAN
  • Patent number: 11534427
    Abstract: The present invention relates to applications of a novel thiazole derivative in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: December 27, 2022
    Assignee: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Honglin Li, Zhenjiang Zhao, Rui Wang, Yufang Xu, Wanqi Wang, Yingfang Yang
  • Publication number: 20220335443
    Abstract: The present disclosure discloses a novel multi-stable and erasable anti-counterfeiting technology with controlled reflection color and the application thereof in optical coding. The method and use are characterized by high thermal stability and robust fatigue resistance, and the realization thereof relies on the material system composed of an intrinsic chiral diarylethene molecule based on steric hindrance ethene bridge and a liquid crystal (LC) material disclosed herein.
    Type: Application
    Filed: October 12, 2020
    Publication date: October 20, 2022
    Applicants: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY, SUZHOU KUNHUANG NEW MATERIAL TECHNOLOGY CO.,LTD.
    Inventors: Weihong Zhu, Zhigang Zheng, Huijun Li, Honglong HU
  • Patent number: 11464795
    Abstract: Provided are use of a saponin compound of formula (I) or (II), or a pharmaceutically acceptable salt, prodrug or solvate thereof, in the manufacture of a medicament targeting PD-1. The medicament targeting PD-1 is one which treats a disease by inhibiting PD-1 from binding to a ligand thereof. The disease may be a tumor, an infection caused by a bacterium, a virus or a fungus, or an inflammatory disease.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: October 11, 2022
    Assignees: East China University Of Science And Technology, Yunnan University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Honglin Li, Weilie Xiao, Lili Zhu, Lina Quan, Qiao Li, Yanyan Diao, Zhenjiang Zhao, Hualiang Jiang
  • Publication number: 20220275282
    Abstract: A method and apparatus for hydrocracking mineralized refuse pyrolysis oil. The method may use the following steps: (a) crushing and pyrolyzing mineralized refuse to obtain arene and alkane precursor biomass oil; (b) hydrogenating the arene and alkane precursor biomass oil obtained in step (a), and separating the obtained hydrocrackate to obtain arene and alkane; and (c) purifying, recovering and optimizing the arene and alkane obtained in step (b), and performing deep processing to produce naphtha, jet fuel, light diesel oil, and heavy diesel oil.
    Type: Application
    Filed: June 16, 2020
    Publication date: September 1, 2022
    Applicant: East China University of Science and Technology
    Inventors: Yulong CHANG, Hualin WANG, Xia JIANG, Jianping LI, Jingyi ZHU, Pengbo FU, Wei YUAN
  • Publication number: 20220226539
    Abstract: The present disclosure relates to a composite scaffold containing DFO and rhBMP-2 capable of synergistically stimulating bone formation, a preparation method and use thereof. The composite scaffold contains a matrix, a PEGS gel layer and rhBMP-2, wherein the matrix is an MBG scaffold grafted with DFO on the surface, the PEGS gel layer is carried on the surface of the matrix, and rhBMP-2 is carried inside the PEGS gel layer. In the present disclosure, the function of DFO and rhBMP-2 in vivo and in vitro can be regulated by precisely controlling the immobilization mode and spatial distribution of DFO and rhBMP-2 in the scaffold, and the all-round repair of “rapid enrichment of target cells—angiogenesis-guided bone” can be achieved.
    Type: Application
    Filed: March 12, 2021
    Publication date: July 21, 2022
    Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Yuan YUAN, Haoyi NIU, Hua HONG, Yongsheng LI, Lili SUN
  • Patent number: 11384036
    Abstract: Disclosed is a method for preparing aromatic hydrocarbons by hydrocracking a polymer containing aromatic rings, which includes reacting the polymer fragment with hydrogen under the action of a catalyst at a temperature of no more than 350° C.; separating a reaction product to obtain the aromatic hydrocarbons. The catalyst comprises a carrier and an active ingredient supported on the carrier, the active ingredient is at least one selected from Ru, Rh, Pt, Pd, Fe, Ni, Cu and Co, the carrier is at least one selected from metal oxide, phosphate, molecular sieve, SiO2 and sulfonated carbon, the metal oxide is at least one selected from Al2O3, Nb2O5, Nb2O5—Al2O3, Nb2O5—SiO2, TiO2, ZrO2, CeO2 and MoO3; the phosphate is at least one selected from NbOPO4 and ZrOPO4; and the molecule sieve is at least one selected from Nb-SBA-15, Nafion, H-ZSM-5, H-Beta and H-Y.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: July 12, 2022
    Assignee: East China University of Science and Technology
    Inventors: Yanqin Wang, Yaxuan Jing, Yong Guo, Xiaohui Liu, Ning Yan
  • Patent number: 11345900
    Abstract: A monooxygenase having an amino acid sequence obtained by mutation of the amino acid sequence shown in SEQ ID NO:2 is disclosed. The use of the monooxygenase of the present invention in production of chiral sulfoxide-based drugs has advantages including mild reaction conditions, environmental friendliness, high yield, high optical purity of products, less peroxide products, and the like, and therefore the monooxygenase in the present invention has a good industrial application prospect in the production of proton pump inhibitors for the treatment of gastric ulcers.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: May 31, 2022
    Assignees: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD., EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Yan Zhang, Huilei Yu, Shimiao Ren, Peng Zhao, Jianhe Xu, Yinqi Wu, Qian Zhao
  • Publication number: 20220145023
    Abstract: The disclosure relates to the field of electronic materials, and in particular to a composite film of fluorinated polybenzoxazole (6FPBO) and triple-shelled mesoporous silica hollow spheres, and to its preparation and use. The composite film comprises fluorinated polybenzoxazole as a matrix and amino-functionalized triple-shelled mesoporous silica hollow spheres which are dispersed in the fluorinated polybenzoxazole matrix. A mass ratio of (amino-functionalized triple-shelled mesoporous silica hollow spheres)/(fluorinated polybenzoxazole) is 1/100 to 5/100. The composite film has excellent thermal stability and a lower dielectric constant.
    Type: Application
    Filed: November 1, 2021
    Publication date: May 12, 2022
    Applicant: East China University of Science and Technology
    Inventors: Qixin ZHUANG, Zhe ZHANG, Xiaoyun LIU, Jian XU, Wentao WANG, Zeyang WU, Xiaohan WU, Lihui LI
  • Patent number: 11320353
    Abstract: A creep strength analysis and assessment method includes comparing whether a maximum value of a local strain and a membrane strain are less than a corresponding allowable strain, and if less, determining that a component is safe; otherwise, performing the following steps: performing stress linearization on a path to obtain a local primary membrane stress PL and a local primary bending stress Pb; averaging shear stress components on the path to obtain an average shear stress ?m; obtaining a strength limit Smt, a time-independent minimum stress strength value Sm and a temperature- and time-dependent stress strength limit St for a given material, a design lifetime and a design temperature; comparing whether PL, PL+Pb and PL+Pb/Kt are less than Smt, KSm and St; and comparing whether ?m is less than 0.6Sm and 0.6St, and if less, the component is safe, otherwise, the component is unsafe.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: May 3, 2022
    Assignee: East China University of Science and Technology
    Inventors: Fuzhen Xuan, Tianye Niu, Jianguo Gong