Patents Assigned to Chinese Academy of Science
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Publication number: 20220195416Abstract: Disclosed are RNA site-directed editing using artificially constructed RNA editing enzymes and related uses. Provided is the fusion of an RNA recognition domain for binding RNA and a functional effector domain to form a new functional protein. The new functional protein specifically targets target RNA by means of the recognition domain and performs RNA editing using the effector domain.Type: ApplicationFiled: March 30, 2020Publication date: June 23, 2022Applicant: SHANGHAI INSTITUTE OF NUTRITION AND HEALTH, CHINESE ACADEMY OF SCIENCESInventors: Zefeng WANG, Wenjian HAN
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Patent number: 11366300Abstract: A STED super-resolution microscope capable of quick beam combination is disclosed, which includes a STED imaging unit and a beam combination test unit. The excitation light and the depletion light are accurately combined by the beam combination test unit, so that the imaging light spots of the two light beams passing through the STED imaging unit can accurately coincide with each other, thereby obtaining a better super-resolution imaging effect.Type: GrantFiled: October 12, 2020Date of Patent: June 21, 2022Assignees: SUZHOU INSTITUTE OF BIOMEDICAL ENGINEERING AND TECHNOLOGY, CHINESE ACADEMY OF SCIENCES, SUZHOU GUOKE MEDICAL TECHNOLOGY DEVELOPMENT (GROUP) CO., LTDInventors: Yuguo Tang, Yunhai Zhang, Tongda Wei, Jian Chang, Haomin Yang, Lin Ji
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Patent number: 11366946Abstract: The present disclosure provides a method and an apparatus for obtaining surface potential.Type: GrantFiled: August 9, 2018Date of Patent: June 21, 2022Assignee: THE INSTITUTE OF MICROELECTRONICS OF CHINESE ACADEMY OF SCIENCESInventors: Nianduan Lu, Ling Li, Ming Liu
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Patent number: 11365165Abstract: An organic base modified composite catalyst for producing ethylene by hydrogenation of carbon monoxide is a composite catalyst and formed by compounding component I and component II in a mechanical mixing mode. The active ingredient of the component I is a metal oxide; the component II is an organic base modified zeolite of MOR topology; and a weight ratio of the active ingredients in the component I to the component II is 0.1-20, and preferably 0.3-8. The reaction process has an extremely high product yield and selectivity. The selectivity of C2-C3 olefins is as high as 78-87%; the selectivity of hydrocarbon products with more than 4 C atoms is less than 10%; the selectivity of a methane side product is extremely low (<9%); and meanwhile, the selectivity of the ethylene is 75-82%.Type: GrantFiled: January 28, 2019Date of Patent: June 21, 2022Assignee: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE Academy of SciencesInventors: Xiulian Pan, Feng Jiao, Xinhe Bao
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Patent number: 11365964Abstract: Disclosed is a stitching-measurement device adapted for performing stitching-measurement on a surface of a concave spherical lens, including: an interferometer, a reference lens, a first plane mirror, a second plane mirror, a first adjustment mechanism, a second adjustment mechanism, a concave spherical object to be measured, a motion table and a control mechanism, the first plane mirror being mounted on the first adjustment mechanism configured to change a position of the first plane mirror; the second plane mirror being mounted on the second adjustment mechanism configured to change a position of the second plane mirror; the concave spherical object to be measured being placed on the motion table configured to change a position of the concave spherical object to be measured; the control mechanism communicating with the interferometer, the first adjustment mechanism, the second adjustment mechanism, and the motion table for issuing control signals, wherein by the first adjustment mechanism and the second adjType: GrantFiled: December 5, 2018Date of Patent: June 21, 2022Assignee: The Institute of Optics and Electronics, The Chinese Academy of SciencesInventors: Fuchao Xu, Xin Jia, Dachun Gan, Tingwen Xing
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Patent number: 11365214Abstract: The invention relates to a method for the treatment of body fluid proteins, by which proteins from body fluids such as blood or urine are extracted by adding a certain proportion of high molecular polymer solution under low temperature condition followed by denaturation and reduction by adding a certain concentration of surfactant and tris(2-carboxyethyl) phosphine (TCEP) under a high temperature condition. Subsequently, the iodoacetic acid brushes grafted on silica microspheres called as solid-phase alkylation reagents are added into protein solution, which can react rapidly with the protein sulfhydryl group. After centrifugation, the microspheres are obtained and repeatedly washed with methanol and buffer to remove interferences such as sugars, salts, surfactants, lipids to obtain high-purity proteins, and finally protease is added to digest proteins into peptides. After centrifugation, the peptide products are obtained, and directly analyzed by liquid chromatography-mass spectrometry (LC-MS) system.Type: GrantFiled: July 12, 2017Date of Patent: June 21, 2022Assignee: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Lihua Zhang, Huiming Yuan, Zhigang Sui, Kaiguang Yang, Yukui Zhang
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Publication number: 20220189588Abstract: Provided is a pedo-transfer function (PTF)-based method for predicting a target soil property. Based on the collection of a multi-source soil dataset and environmental variables, a dataset containing all measured information is divided. Second-level regions are obtained by zoning according to the spatial variation in soil properties. An optimal independent variable set of PTFs in different regions is obtained by screening. Then, linear fitting and nonlinear fitting of the PTFs are performed for different zones separately. By comparing the accuracy of different functions between different zones, optimal PTFs oriented toward sampling sites are selected, so as to build a database including soil sampling sites. Further, regional independent variable layers are constructed by means of machine learning, to establish region-oriented PTFs; and a spatial distribution map of the target soil property and content for a target region is produced.Type: ApplicationFiled: January 16, 2022Publication date: June 16, 2022Applicant: INSTITUTE OF SOIL SCIENCE, CHINESE ACADEMY OF SCIENCESInventors: Xiaodong SONG, Ganlin ZHANG, Decheng LI, Feng LIU, Huayong WU, Fei YANG, Jinling YANG, Yuguo ZHAO
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Publication number: 20220186181Abstract: Provided are a culture medium for expanding and cultivating human liver progenitor cells and an application thereof. The chemical components of the formula of the described culture medium are clear, no serum is present, and various components thereof cooperate with each other to synergize. The culture medium is used for the long-term expansion and cultivation of liver progenitor cells in vitro and is used for maintaining the dryness thereof, is beneficial in quickly and efficiently obtaining a large number of functional liver cells, and is suitable for clinical hepatocyte transplantation application as well as for the use of hepatocyte reactors in bioartificial livers.Type: ApplicationFiled: December 19, 2019Publication date: June 16, 2022Applicant: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesInventors: Yinxiong Li, Tingcai Pan, Yan Chen, Yuanqi Zhuang, Fan Yang
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Patent number: 11362328Abstract: The invention provides a composite-coated nano-tin negative electrode material, which comprises a tin-based nanomaterial, a nano-copper layer coated on the surface of the tin-based nanomaterial and a conductive protective layer coated on the surface of the nano-copper layer. The nano-copper layer can inhibit the volume expansion of nano-tin, keep the nano-tin material from cracking, avoid direct contact between nano-tin and electrolyte to form stable SEI and increase the conductivity of the electrode. Coating a conductive layer on the surface of the nano-copper layer can effectively inhibit the oxidation of nano-copper, thus improving its electrochemical performance. The composite-coated nano-tin negative electrode material according to the invention is used as a negative electrode material of a lithium-ion battery, has excellent electrochemical performance, and has potential application prospects in portable mobile devices and electric vehicles.Type: GrantFiled: September 29, 2018Date of Patent: June 14, 2022Assignee: INSTITUTE OF PHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Zhou Jin, Hailong Yu, Xuejie Huang
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Patent number: 11360225Abstract: The present disclosure provides an earthquake evaluation method based on multi-type geophysical data.Type: GrantFiled: February 24, 2022Date of Patent: June 14, 2022Assignee: Institute of Geology and Geophysics, Chinese Academy of SciencesInventors: Qingyun Di, Fei Tian, Yongyou Yang, Zhongxing Wang, Wenhao Zheng, Renzhong Pei, Wenxiu Zhang
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Patent number: 11362327Abstract: This invention relates to a double layer composite-coated nano-silicon negative electrode material, and its preparation methods and use, the negative electrode material comprising: a silicon-based nanoparticle, a copper layer coated on the surface of the silicon-based nanoparticle, and a conductive protective layer coated on the surface of the copper layer. Nano-copper has superplastic ductility and conductivity, and the prior art has proved that lithium ions can penetrate nano-copper; therefore, the copper coating layer has effects of inhibiting the volume expansion of the silicon-based nanoparticle and keeping the silicon-based nanoparticle from cracking so that direct contact between the silicon-based nanoparticle and an electrolyte is effectively avoided and a stable SEI is formed, and increasing the conductivity of the electrode.Type: GrantFiled: September 5, 2017Date of Patent: June 14, 2022Assignee: INSTITUTE OF PHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Zhou Jin, Hailong Yu, Xuejie Huang
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Patent number: 11361799Abstract: A semiconductor memory device including a substrate; an array of memory cells arranged in rows and columns on the substrate, each memory cell comprising a vertical pillar-shaped active region having upper and lower source/drain regions and a channel region, and a gate stack formed around the channel region; a plurality of bit lines on the substrate, each bit line located below a column of memory cells and electrically connected to the lower source/drain regions of the memory cells; and a plurality of word lines on the substrate, each word line extending in a row direction and connected to gate conductors of the memory cells in a row of memory cells, each word line comprising first portions extending along peripheries of the memory cells and second portions extending between the first portions, the first portions of the word line extending in a conformal manner with sidewalls of the upper source/drain regions.Type: GrantFiled: September 21, 2018Date of Patent: June 14, 2022Assignee: INSTITUTE OF MICROELECTRONICS, CHINESE ACADEMY OF SCIENCESInventor: Huilong Zhu
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Patent number: 11359276Abstract: A self-supporting ultra-fine nanocrystalline diamond thick film, the thickness being 100-3000 microns, wherein 1 nanometer?diamond grain size?20 nanometers. A method for using chemical vapor deposition to grow ultra-fine nanocrystalline diamond on a silicon substrate, and separating the silicon substrate and the diamond to acquire the self-supporting ultra-fine nanocrystalline diamond thick film. The chemical vapor deposition method is simple and effective, and prepares a high-quality ultra-fine nanocrystalline diamond thick film.Type: GrantFiled: April 18, 2018Date of Patent: June 14, 2022Assignee: NINGBO INSTITUTE OF MATERIALS TECHNOLOGY & ENGINEERING, CHINESE ACADEMY OF SCIENCESInventors: Nan Jiang, He Li, Bo Wang, Jian Yi, Yang Cao
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Patent number: 11362482Abstract: An integrated Fourier domain mode-locked optoelectronic oscillator and its application and a communication system are provided, which relates to the technical field of microwave photonics. The integrated Fourier domain mode-locked optoelectronic oscillator includes an optoelectronic chip and an electronic chip. The optoelectronic chip includes a laser, a modulator, an optical notch filter, and a photodetector coupled via an optical waveguide. The electronic chip includes an electrical amplifier and a power splitter coupled via a coplanar microwave waveguide. The volume, weight and power consumption of the Fourier domain mode-locked optoelectronic oscillator is greatly reduced by integrating all the devices on the chip. A tunable sweeping microwave signal output is realized, and the sweeping speed of the output signal is increased. The integrated Fourier domain mode-locked optoelectronic oscillator can be used in radars and communication systems.Type: GrantFiled: May 11, 2020Date of Patent: June 14, 2022Assignee: Institute of Semiconductors, Chinese Academy of SciencesInventors: Ming Li, Tengfei Hao, Dapeng Liu, Nuannuan Shi, Wei Li, Ninghua Zhu
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Patent number: 11360037Abstract: A classified characterization method for connectivity of organic matter (OM)-hosted pores in shale includes: scanning a shale sample according to a preset imaging area through a scanning electron microscope to acquire a 2D image of the shale sample; extracting pore parameters of each OM in the 2D image by Avizo software; acquiring a class number of OM sets according to the pore parameters; performing 3D reconstruction on each class of OM sets through a focused ion beam-helium ion microscope to acquire reconstructed 3D models of the OM; acquiring a pore connectivity parameter by the Avizo software; and acquiring an evaluation index for overall connectivity of the OM-hosted pores in the shale based on the pore connectivity parameter. The classified characterization method is based on the morphologically quantitative classification of the OM-hosted pores, and can realize the 3D characterization of connectivity of pores below 10 nm.Type: GrantFiled: January 23, 2022Date of Patent: June 14, 2022Assignee: INSTITUTE OF GEOLOGY AND GEOPHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Jianguo Wu, Jijin Yang, Guoliang Li
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Patent number: 11359485Abstract: An acoustic while drilling receiving transducer array adopts a full-digital structure and a non-oil-filled rubber encapsulation arrangement mode, and the full-digital device of the acoustic while drilling receiving transducer array includes first modules, configured to carry out acoustic-to-electric conversion on weakly received acoustic signals of strata; second modules, configured to carry out amplification, filtering, gain control and digital-to-analog conversion on the weakly received acoustic signals; and a third module, configured to control interfaces of the device and convert external input and output signals.Type: GrantFiled: April 5, 2021Date of Patent: June 14, 2022Assignee: Institute of Geology and Geophysics, Chinese Academy of SciencesInventors: Yuntao Sun, Wenxuan Chen, Qingyun Di, Jian Zheng, Wenxiu Zhang
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Patent number: 11358767Abstract: A laser sample chamber for deep space exploration includes a sample chamber base and a sample chamber top cover. The sample chamber base is a hollow cylinder with bottom end being sealed and top end being open, and an internal cavity in the hollow cylinder is provided for receiving sample plates; and a body of the sample chamber top cover is a hollow cylinder with a top end being sealed and a bottom end being open, and the body consists of a plurality of components which comprise a hollow annulus positioned at a middle of the sample chamber top cover, a circular viewing window positioned at an opening at a top end of the hollow annulus, and a threaded port positioned at an opening at a bottom end of the hollow annulus and protruding outward.Type: GrantFiled: December 30, 2020Date of Patent: June 14, 2022Assignee: INSTITUTE OF GEOLOGY AND GEOPHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Yinzhi Wang, Fei Wang, Wenbei Shi, Liekun Yang
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Patent number: 11362205Abstract: A group III nitride enhancement-mode HEMT based on a composite barrier layer structure and a manufacturing method thereof are provided. The HEMT includes first and second semiconductors respectively serving as a channel layer and a barrier layer, a third semiconductor serving as a p-type layer, a source, a drain and a gate, wherein a recessed structure is formed in the region of the barrier layer corresponding to the gate, which is matched with the third semiconductor and the gate to form a p-type gate, and the second semiconductor includes first and second structure layers successively arranged on the first semiconductor; relative to the selected etching reagent, the first structure layer has higher etching resistance than the second structure layer.Type: GrantFiled: April 10, 2018Date of Patent: June 14, 2022Assignee: SUZHOU INSTITUTE OF NANO-TECH AND NANO-BIONICS (SINANO), CHINESE ACADEMY OF SCIENCESInventors: Qian Sun, Yu Zhou, Yaozong Zhong, Hongwei Gao, Meixin Feng, Hui Yang
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Publication number: 20220181150Abstract: A method of making a silicon on insulator structure comprises: providing a bonded structure, the bonded structure comprises the first substrate, the second substrate and the insulating buried layer, the insulating buried layer is positioned between the first substrate and the second substrate; peeling off a layer of removing region of the first substrate from the bonded structure to obtain a first film; at a first temperature, performing a first etching to etch the first film to remove a first thickness of the first film; at a second temperature, performing a second etching to etch the first film to planarize the first film and remove a second thickness of the first film, the first temperature being lower than the second temperature, the first thickness being greater than the second thickness, and a sum of the first thickness and the second thickness being a total etching thickness of the first film.Type: ApplicationFiled: January 28, 2021Publication date: June 9, 2022Applicants: Zing Semiconductor Corporation, SHANGHAI INSTITUTE OF MICROSYSTEM AND INFORMATION TECHNOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Xing WEI, Nan GAO, Zhongying XUE
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Publication number: 20220181200Abstract: The present invention provides a method of making a silicon on insulator (SOI) structure, comprising steps of: providing a bonded structure, the bonded structure comprises a first substrate, a second substrate and an insulating buried layer, the insulating buried layer is positioned between the first substrate and the second substrate; peeling off a layer of removing region of the first substrate from the bonded structure to obtain a SOI structure; and processing the SOI structure with isothermal annealing technology at a pressure which is lower than atmospheric pressure.Type: ApplicationFiled: March 3, 2021Publication date: June 9, 2022Applicants: Zing Semiconductor Corporation, SHANGHAI INSTITUTE OF MICROSYSTEM AND INFORMATION TECHNOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Xing WEI, Nan GAO, Zhongying XUE