Abstract: The present invention relates to an active inclusion complex of Taxol, Taxotere or a Taxus extract formed with a cyclodextrin-derivative, a pharmaceutical composition containing the same, a process of preparation and a method of treatment.
Type:
Grant
Filed:
December 8, 1995
Date of Patent:
September 4, 2001
Assignee:
Chinoin, Ltd.
Inventors:
Lajos Szente, József Szejtli, Andrasne Vikmon
Abstract: This invention provides liposomic composition, containing as active ingredient (-)-N-.alpha.-dimethyl-N-(2-propynylphenylethylamine) (selegilin) and/or salt thereof. This composition contains: 0.1-40% by weight of selegilin and/or a salt thereof, 2 to 40% by weight of lipids, preferably phospholipids, 0 to 10% by weight of cholesterol, 0 to 20% by weight of an alcohol, 0 to 25% by weight of a glycol, 0 to 3% by weight of an antioxidant, 0 to 3% by weight of a preserving agent, 0 to 2% by weight of a viscosity influencing agent, 0 to 50% by weight of cyclodextrin or a cyclodextrin derivative and 30 to 90% by weight of water. This invention relates to pharmaceutical composition, containing the liposomic composition described and if desired, usual filling and diluting agents and other auxiliaries, preferably in oral, parenteral or transdermal form. This invention provides the process for the preparation of liposomic compositions containing selegilin and/or salt thereof.
Type:
Grant
Filed:
August 5, 1997
Date of Patent:
March 30, 1999
Assignee:
Chinoin Ltd.
Inventors:
Michael Mezei, Jozsef Gaal, Gabor Szekacs, Gyula Szebeni, Katalin Marmarosi, Kalman Magyar, Jozsef Lengyel, Istvan Szatmari, Agnes Turi
Abstract: The invention relates to a novel process for the preparation of 13,14-dihydro-15 (R)-17-phenyl-18,19,20-trinor-PGF.sub.2.alpha. isopropyl ester of the formula (I)--wherein R stands for saturated or unsaturated straight, branched or cyclic C.sub.
Type:
Grant
Filed:
October 6, 1994
Date of Patent:
November 14, 1995
Assignees:
Kabi Pharmacia AB, Chinoin Ltd.
Inventors:
Jozsef Ivanics, Tibor Szabo, Istvan Hermecz, Gyula Dalmadi, Jozsefne Ivanics, Gaborne Kovacs, Resul Bahram