Patents Assigned to Chipscreen Biosciences, Ltd.
  • 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS
    Publication number: 20090298886
    Abstract: The present invention relates to 2-indolinone derivatives which are capable of inhibiting protein kinases and histone deacetylases. The compounds of this invention are therefore useful in treating diseases associated with abnormal protein kinase activities or abnormal histone deacetylase activities. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing these compounds are also disclosed.
    Type: Application
    Filed: May 8, 2009
    Publication date: December 3, 2009
    Applicant: Chipscreen Biosciences, Ltd.
    Inventors: Xian-Ping LU, Zhi-Bin LI, Zhi-Qiang Ning
  • TRICYCLIC DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS
    Publication number: 20090292001
    Abstract: The present invention relates to certain tricyclic derivatives which are capable of inhibiting histone deacetylases. The compounds of this invention are therefore useful in treating diseases associated with abnormal histone deacetylase activities. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing these compounds are also disclosed.
    Type: Application
    Filed: May 8, 2009
    Publication date: November 26, 2009
    Applicant: Chipscreen Biosciences, Ltd.
    Inventors: Xian-Ping LU, Zhi-Bin Li, Zhi-Qiang Ning
  • 2-INDOLINONE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE INHIBITORS
    Publication number: 20090182029
    Abstract: Provided herein are isolated compounds of formula 1: processes for their preparation and isolation, as well as pharmaceutical compositions which comprise these therapeutic agents, and methods of use therefore the treatment and/or control of conditions associated with or mediated by effects of histone deacetylase.
    Type: Application
    Filed: January 14, 2009
    Publication date: July 16, 2009
    Applicant: Chipscreen Biosciences, Ltd.
    Inventors: Xian-Ping Lu, Zhi-bin Li, Zhi-Qiang Ning
  • Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity
    Patent number: 7192970
    Abstract: Disclosed are the preparation and pharmaceutical use of novel noncyclic 1,3-dicarbonyl compounds of formula I, wherein ring A, ring B, R1, R2, R3, R4, R5, X, Y, Z, Q, Ar and n are as defined in the specification.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: March 20, 2007
    Assignee: Chipscreen Biosciences, Ltd.
    Inventors: Xian-Ping Lu, Zhibin Li, Chenzhong Liao, Leming Shi, Zhende Liu, Zhiqiang Ning, Song Shan, Tuo Deng, Baoshun Ma