Patents Assigned to Chiragene, Inc.
  • Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes
    Patent number: 6025516
    Abstract: The present invention provides an efficient route to the C-13 side chain of the anti-cancer drug paclitaxel (TAXOL) and its analogs. The process includes the resolution of racemic erythro 2-hydroxy-3-amino-3-phenylpropionamide by diastereomeric crystallization and its conversion via various intermediates to the threo-ethylester and threo-methylester isomers.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: February 15, 2000
    Assignee: Chiragene, Inc.
    Inventors: Sowmianarayanan Ramaswamy, Venkat G. Reddy, Yalin Luo