Patents Assigned to Chiralix B.V.
  • Chemiluminescence-based haemostasis assay
    Patent number: 9856510
    Abstract: The present invention relates to a method for in vitro determining generation of a haemostatis factor such as thrombin and/or plasmin in a test sample using a chemiluminescent substrate specific for said blood clotting factor. Upon cleavage of the substrate, a luminescent signal is generated via aminoluceferin with the aid of a luciferase. The invention also relates to a kit for in vitro determining generation of a haemostasis factor in a test sample, and to novel chemiluminescent substrates for the determination of thrombin and plasmin.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: January 2, 2018
    Assignees: Stichting Katholieke Universiteit, Chiralix B.V.
    Inventors: Waander Laurens van Heerde, Richard Hendrik Blaauw
  • CHEMILUMINESCENCE-BASED HAEMOSTASIS ASSAY
    Publication number: 20130337480
    Abstract: The present invention relates to a method for in vitro determining generation of a haemostatis factor such as thrombin and/or plasmin in a test sample using a chemiluminescent substrate specific for said blood clotting factor. Upon cleavage of the substrate, a luminescent signal is generated via aminoluceferin with the aid of a luciferase. The invention also relates to a kit for in vitro determining generation of a haemostasis factor in a test sample, and to novel chemiluminescent substrates for the determination of thrombin and plasmin.
    Type: Application
    Filed: December 14, 2011
    Publication date: December 19, 2013
    Applicants: CHIRALIX B.V., STICHTING KATHOLIEKE UNIVERSITEIT
    Inventors: Waander Laurens Van Heerde, Richard Hendrik Blaauw
  • Peptidylarginine deiminase (PAD) inhibitors
    Patent number: 8404647
    Abstract: The invention relates to PAD inhibitors that are suitable to be used as a medicament against an autoimmune disease such as RA.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: March 26, 2013
    Assignees: Chiralix B.V., Modiquest B.V., Academisch Ziekenhuis Leiden H.O.D.N. Lumc
    Inventors: Richard Hendrik Blaauw, Gerardus Jozef Maria Pruijn, Jozef Maria Hendrik Raats, Floris Petrus Johannes Theodorus Rutjes, Jan Wouter Drijfhout
  • Peptidylarginine Deiminase (PAD) Inhibitors
    Publication number: 20110142868
    Abstract: The invention relates to PAD inhibitors that are suitable to be used as a medicament against an autoimmune disease such as RA.
    Type: Application
    Filed: December 10, 2010
    Publication date: June 16, 2011
    Applicants: Chiralix B.V., ModiQuest V.V., Academisch Ziekenhuis Leiden h.o.d.n. LUMC
    Inventors: Richard Hendrik Blaauw, Gerardus Jozef Maria Pruijn, Jozef Maria Hendrik Raats, Floris Petrus Johannes Theodorus Rutjes, Jan Wouter Drijfhout