Abstract: Methods of treating a human subject for a cancer characterized by neoplastic B cell growth are provided. The methods comprise administering combination antibody therapy to the subject, where an effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof in combination with an anti-CD20 antibody or antigenbinding fragment thereof is administered to the subject. The invention further comprises pharmaceutical compositions with combinations of these antibodies in a pharmaceutically acceptable carrier.
Type:
Application
Filed:
November 4, 2004
Publication date:
May 3, 2007
Applicant:
Chiron
Inventors:
Li Long, Mohammad Luqman, Asha Yabannavar, Isabel Zaror