Abstract: Deuterium free, stable isotope labeled hallucinogens and/or stimulants containing a 2-phenylethylamine-based structural unit and containing at least three stable isotopes selected from the group consisting of 13C, 15N and 18O as free bases and as their salts; method of their preparation and their use in the chemical analysis, in particular forensic chemical analysis, and in metabolic studies.
Type:
Grant
Filed:
July 27, 2012
Date of Patent:
September 6, 2016
Assignee:
CHIRON AS
Inventors:
Jon Eigill Johansen, Huiling Liu, Morten Karlsen
Abstract: A test kit for the quantitative determination of narcotic drugs comprising (A) series of sealed vessels, each vessel containing a deuterium free isotopologue of a narcotic drug in exactly defined concentrations and quantities, wherein the isotopologue differs from vessel to vessel and—wherein the quantities of the isotopologue differ from vessel to vessel or are the same for all vessels; and/or (B) series of sealed vessels, each vessel containing in exactly defined concentrations and quantities the same isotopologue in quantities which differ from vessel to vessel; wherein the free isotopologues are selected from narcotic drugs; prodrugs, salts, solvates, hydrates and polymorphs and contain at least three stable isotopes selected from the group consisting of 13C, 15N and 18O in the molecule with a degree of labeling of at least 95 mol-%; the use of the test kit and a method for quantitatively determining narcotic drugs.
Type:
Grant
Filed:
July 19, 2013
Date of Patent:
May 24, 2016
Assignee:
CHIRON AS
Inventors:
Morten Salihi Karlsen, Huiling Liu, Jon Eigill Johansen
Abstract: Congeneric, halogenated, fluorinated aromatic compounds A and B are each phenyl radicals, L=oxygen atom, sulfur atom or alkylene radical and p=0 or 1; processes for their preparation and their use.
Type:
Grant
Filed:
May 31, 2011
Date of Patent:
July 9, 2013
Assignee:
Chiron AS
Inventors:
Huiling Liu, Gregor Luthe, Jon Eigill Johansen
Abstract: Congeneric, halogenated, fluorinated aromatic compounds where A and B are each phenyl radicals, L=oxygen atom, sulfur atom or alkylene radical and p=0 or 1; processes for their preparation and their use.
Type:
Application
Filed:
May 31, 2011
Publication date:
September 22, 2011
Applicant:
CHIRON AS
Inventors:
Huiling LIU, Gregor LUTHE, Jon Eigill JOHANSEN