Patents Assigned to Chiron Corp.
  • Method for using lipoprotein associated coagulation inhibitor to treat sepsis
    Patent number: 6063764
    Abstract: A method for prophylactically or therapeutically treating sepsis or septic shock is described, wherein an inhibitor to tissue factor is administered to septic patients. Additionally, a method for treating inflammation is described wherein the inhibitor is administered to pateints. This inhibitor is termed lipoprotein associated coagulation inhibitor, or commonly LACI. It is 38 kD and has 276 amino acids. LACI has now been shown to be useful for the treatment of sepsis, septic shock and inflammation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 16, 2000
    Assignee: Washington University & Chiron Corp.
    Inventors: Abla A. Creasey, George J. Broze
  • Peptide plasminogen activators
    Patent number: 5656269
    Abstract: Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, reduced fibrin stimulation of plasminogenolytic activity and/or enhanced affinity to fibrin surfaces are provided by modifying the C-terminus by deletions.
    Type: Grant
    Filed: January 31, 1995
    Date of Patent: August 12, 1997
    Assignees: Chiron Corp., Behringwerke AG
    Inventors: Nancy L. Haigwood, Guy Mullenbach, Ernst-Guenter Afting, Eric Paul Paques