Patents Assigned to Chiron Corp.
  • Peptide plasminogen activators
    Patent number: 5656269
    Abstract: Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, reduced fibrin stimulation of plasminogenolytic activity and/or enhanced affinity to fibrin surfaces are provided by modifying the C-terminus by deletions.
    Type: Grant
    Filed: January 31, 1995
    Date of Patent: August 12, 1997
    Assignees: Chiron Corp., Behringwerke AG
    Inventors: Nancy L. Haigwood, Guy Mullenbach, Ernst-Guenter Afting, Eric Paul Paques